{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:40:03Z","timestamp":1748047203427,"version":"3.41.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Agriculture and Food Research Initiative Competitive","award":["2016-67015-24958"],"award-info":[{"award-number":["2016-67015-24958"]}]},{"DOI":"10.13039\/100005825","name":"USDA National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to determine whether the acceleration of conceptus development induced by the administration of exogenous progesterone (P4) during the preimplantation period of pregnancy alters calcium, phosphate, and vitamin D signaling at the maternal\u2013conceptus interface. Suffolk ewes (n\u2009=\u200948) were mated to fertile rams and received daily intramuscular injections of either corn oil (CO) vehicle or 25\u00a0mg of progesterone in CO (P4) for the first 8\u00a0days of pregnancy and hysterectomized on either Day 9 (CO, n\u2009=\u20095; P4, n\u2009=\u20096), 12 (CO, n\u2009=\u20099; P4, n\u2009=\u20094) or 125 (CO, n\u2009=\u200914; P4, n\u2009=\u200910) of gestation. The expression of S100A12 (P\u2009&amp;lt;\u20090.05) and fibroblast growth factor receptor (FGFR2) (P\u2009&amp;lt;\u20090.01) messenger RNAs (mRNAs) was lower in endometria from P4-treated ewes on Day 12. The expression of ADAM10 (P\u2009&amp;lt;\u20090.05) mRNA was greater in endometria from P4-treated ewes on Day 125. The expression of ADAM10 (P\u2009&amp;lt;\u20090.01), FGFR2 (P\u2009&amp;lt;\u20090.05), solute carrier (SLC)20A1 (P\u2009&amp;lt;\u20090.05), TRPV5 (P\u2009&amp;lt;\u20090.05), and TRPV6 (P\u2009&amp;lt;\u20090.01) mRNAs was greater, but KL mRNA expression was lower (P\u2009&amp;lt;\u20090.05) in placentomes from P4-treated ewes at Day 125. There was lower endometrial and greater placentomal expression of mRNAs involved in mineral metabolism and transport in twin compared to singleton pregnancies. Further, the expression of mRNAs involved in mineral metabolism and transport was greater in P4-treated twin placentomes. KL, FGF23, vitamin D receptor (VDR), S100A9, S100A12, S100G, and CYP27B1 proteins were immunolocalized in endometria and placentomes. Exogenous P4 in early pregnancy altered the expression of regulators of calcium, phosphate, and vitamin D on Day 125 of pregnancy indicating a novel effect of P4 on mineral transport at the maternal\u2013conceptus interface.<\/jats:p>","DOI":"10.1093\/biolre\/ioac042","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T12:00:20Z","timestamp":1645531220000},"page":"1126-1142","source":"Crossref","is-referenced-by-count":7,"title":["Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes"],"prefix":"10.1093","volume":"106","author":[{"given":"Claire","family":"Stenhouse","sequence":"first","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine M","family":"Halloran","sequence":"additional","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C","family":"Hoskins","sequence":"additional","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makenzie G","family":"Newton","sequence":"additional","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn M","family":"Moses","sequence":"additional","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heewon","family":"Seo","sequence":"additional","affiliation":[{"name":"Veterinary Integrative Biosciences , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin A","family":"Dunlap","sequence":"additional","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C","family":"Satterfield","sequence":"additional","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Gaddy","sequence":"additional","affiliation":[{"name":"Veterinary Integrative Biosciences , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Veterinary Integrative Biosciences , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry J","family":"Suva","sequence":"additional","affiliation":[{"name":"Veterinary Physiology and Pharmacology , , College Station, Texas","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuller W","family":"Bazer","sequence":"additional","affiliation":[{"name":"Department of Animal Science , , College Station, Texas,","place":["USA"]},{"name":"Texas A&M University , , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"2025052320022514700_ref1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0021-9258(19)51339-4","article-title":"The chemical composition of the adult human body and its bearing on the biochemistry of growth","volume":"168","author":"Mitchell","year":"1945","journal-title":"J Biol 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