{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:28:40Z","timestamp":1793406520196,"version":"4.5.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANID Postdoctoral Scholarship","award":["74190055"],"award-info":[{"award-number":["74190055"]}]},{"name":"Programa Institucional de Internacionaliza\u00e7\u00e3o","award":["88887.508140\/2020-00"],"award-info":[{"award-number":["88887.508140\/2020-00"]}]},{"name":"Sir Henry Wellcome Postdoctoral Fellowship","award":["220456\/Z\/20\/Z"],"award-info":[{"award-number":["220456\/Z\/20\/Z"]}]},{"name":"Newton International Fellowship from the Royal Society","award":["NF170988\/RG90199"],"award-info":[{"award-number":["NF170988\/RG90199"]}]},{"name":"Lister Institute of Preventative Medicine Research Prize","award":["MR\/R022690\/1\/RG93186"],"award-info":[{"award-number":["MR\/R022690\/1\/RG93186"]}]},{"name":"Lister Institute of Preventative Medicine Research Prize","award":["RG93692"],"award-info":[{"award-number":["RG93692"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fetal growth depends on placental function, which requires energy from mitochondria. Here we investigated whether mitochondrial function in the placenta relates to the growth of the lightest and heaviest fetuses of each sex within the litter of mice. Placentas from the lightest and heaviest fetuses were taken to evaluate placenta morphology (stereology), mitochondrial energetics (high-resolution respirometry), mitochondrial regulators, nutrient transporters, hormone handling, and signaling pathways (qPCR and Western blotting). We found that mitochondrial complex I and II oxygen consumption rate was greater for placentas supporting the lightest female fetuses, although placental complex I abundance of the lightest females and complexes III and V of the lightest males were decreased compared to their heaviest counterparts. Expression of mitochondrial biogenesis (Nrf1) and fission (Drp1 and Fis1) genes was lower in the placenta from the lightest females, whilst biogenesis-related gene Tfam was greater in the placenta of the lightest male fetuses. In addition, placental morphology and steroidogenic gene (Cyp17a1 and Cyp11a1) expression were aberrant for the lightest females, but glucose transporter (Slc2a1) expression was lower in only the lightest males versus their heaviest counterparts. Differences in intra-litter placental phenotype were related to changes in the expression of hormone-responsive (androgen receptor) and metabolic signaling (AMPK, AKT, and PPAR\u03b3) pathways. Thus, in normal mouse pregnancy, placental structure, function, and mitochondrial phenotype are differentially responsive to the growth of the female and male fetus. This study may inform the design of sex-specific therapies for placental insufficiency and fetal growth abnormalities with life-long benefits for the offspring.<\/jats:p>","DOI":"10.1093\/biolre\/ioac056","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T09:03:32Z","timestamp":1647421412000},"page":"1292-1311","source":"Crossref","is-referenced-by-count":31,"title":["Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice"],"prefix":"10.1093","volume":"106","author":[{"given":"Esteban","family":"Salazar-Petres","sequence":"first","affiliation":[{"name":"Department of Physiology , Development and Neuroscience, Centre for Trophoblast Research, , Cambridge , UK"},{"name":"University of Cambridge , Development and Neuroscience, Centre for Trophoblast Research, , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pereira-Carvalho","sequence":"additional","affiliation":[{"name":"Department of Physiology , Development and Neuroscience, Centre for Trophoblast Research, , Cambridge , UK"},{"name":"University of Cambridge , Development and Neuroscience, Centre for Trophoblast Research, , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Lopez-Tello","sequence":"additional","affiliation":[{"name":"Department of Physiology , Development and Neuroscience, Centre for Trophoblast Research, , Cambridge , UK"},{"name":"University of Cambridge , Development and Neuroscience, Centre for Trophoblast Research, , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Nancy","family":"Sferruzzi-Perri","sequence":"additional","affiliation":[{"name":"Department of Physiology , Development and Neuroscience, Centre for Trophoblast Research, , Cambridge , UK"},{"name":"University of Cambridge , Development and Neuroscience, Centre for Trophoblast Research, , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"2022072712532960700_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2018.01091","article-title":"The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation","volume":"9","author":"Napso","year":"2018","journal-title":"Front Physiol"},{"key":"2022072712532960700_ref2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1113\/jphysiol.2009.181214","article-title":"Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice","volume":"3","author":"Coan","year":"2010","journal-title":"J Physiol"},{"key":"2022072712532960700_ref3","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1113\/jphysiol.2008.156133","article-title":"Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice","volume":"586","author":"Coan","year":"2008","journal-title":"J Physiol"},{"key":"2022072712532960700_ref4","doi-asserted-by":"crossref","first-page":"19219","DOI":"10.1073\/pnas.0504468103","article-title":"Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems","volume":"102","author":"Const\u00e2ncia","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022072712532960700_ref5","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1073\/pnas.0911710107","article-title":"Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport","volume":"107","author":"Dilworth","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022072712532960700_ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2017.01050","article-title":"Adaptations in Maternofetal calcium transport in relation to placental size and Fetal sex in mice","volume":"8","author":"Hayward","year":"2017","journal-title":"Front Physiol"},{"key":"2022072712532960700_ref7","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1096\/fj.13-234823","article-title":"An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory","volume":"27","author":"Sferruzzi-Perri","year":"2013","journal-title":"FASEB J"},{"key":"2022072712532960700_ref8","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1113\/JP271057","article-title":"Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy","volume":"594","author":"Higgins","year":"2016","journal-title":"J Physiol"},{"key":"2022072712532960700_ref9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.placenta.2006.02.011","article-title":"The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive Conductances","volume":"28","author":"Mayhew","year":"2007","journal-title":"Placenta"},{"key":"2022072712532960700_ref10","first-page":"935","article-title":"Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet","volume":"576","author":"Jansson","year":"2006","journal-title":"J Physiol"},{"key":"2022072712532960700_ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-72930-7","article-title":"Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction","volume":"10","author":"McIntyre","year":"2020","journal-title":"Sci Rep"},{"key":"2022072712532960700_ref12","doi-asserted-by":"crossref","DOI":"10.5772\/55384","article-title":"The role of placenta in the Fetal programming associated to gestational diabetes","author":"Escudero","year":"2013","journal-title":"Gestational Diabetes - Causes, Diagnosis and Treatment [Internet]"},{"key":"2022072712532960700_ref13","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Expert reviews pathophysiology of placental-derived fetal growth restriction","volume":"218","author":"Burton","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"2022072712532960700_ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.01027","article-title":"Physiology and pathophysiology of steroid biosynthesis, transport and metabolism in the human placenta","volume":"9","author":"Chatuphonprasert","year":"2018","journal-title":"Front Pharmacol"},{"key":"2022072712532960700_ref15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.placenta.2020.11.012","article-title":"Placental mitochondrial function in response to gestational exposures","volume":"104","author":"Lu","year":"2021","journal-title":"Placenta"},{"key":"2022072712532960700_ref16","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201511036","article-title":"Metabolic regulation of mitochondrial dynamics","volume-title":"J Cell Biol.","author":"Mishra","year":"2016"},{"key":"2022072712532960700_ref17","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1530\/REP-06-0369","article-title":"Nutritional manipulation between early to mid-gestation: effects on uncoupling protein-2, glucocorticoid sensitivity, IGF-1 receptor and cell proliferation but not apoptosis in the ovine placenta","volume":"134","author":"Gnanalingham","year":"2007","journal-title":"Reproduction"},{"key":"2022072712532960700_ref18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1095\/biolreprod.110.083907","article-title":"Antioxidant defenses in the rat placenta in late gestation: increased labyrinthine expression of superoxide dismutases, glutathione peroxidase 3, and uncoupling protein","volume":"83","author":"Jones","year":"2010","journal-title":"Bio Reprod"},{"key":"2022072712532960700_ref19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.placenta.2016.12.012","article-title":"Review: placental mitochondrial function and structure in gestational disorders","volume":"54","author":"Holland","year":"2017","journal-title":"Placenta"},{"key":"2022072712532960700_ref20","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.placenta.2012.09.010","article-title":"Localisation and characterisation of uncoupling protein-2 (UCP2) in the human preterm placenta","volume":"33","author":"Stark","year":"2012","journal-title":"Placenta"},{"key":"2022072712532960700_ref21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1152\/ajpendo.00332.2012","article-title":"Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats","volume":"304","author":"Mayeur","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022072712532960700_ref22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10735-013-9522-7","article-title":"Gestational protein restriction induces alterations in placental morphology and mitochondrial function in rats during late pregnancy","volume":"44","author":"Rebelato","year":"2013","journal-title":"J Mol Histol"},{"key":"2022072712532960700_ref23","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1152\/physiolgenomics.00059.2014","article-title":"In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring","volume":"46","author":"Borengasser","year":"2014","journal-title":"Physiol Genom"},{"key":"2022072712532960700_ref24","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1073\/pnas.1816056116","article-title":"Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth","volume":"116","author":"Sferruzzi-Perri","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022072712532960700_ref25","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1210\/en.2015-1227","article-title":"Sex-specific placental responses in fetal development","volume":"156","author":"Rosenfeld","year":"2015","journal-title":"Endocrinology"},{"key":"2022072712532960700_ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2019.02.008","article-title":"Sex modifies placental gene expression in response to metabolic and inflammatory stress","volume":"78","author":"Barke","year":"2019","journal-title":"Placenta"},{"key":"2022072712532960700_ref27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1095\/biolreprod.108.073312","article-title":"Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice","volume":"81","author":"Sferruzzi-Perri","year":"2009","journal-title":"Biol Reprod"},{"key":"2022072712532960700_ref28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ab.2010.02.036","article-title":"Reversible Ponceau staining as a loading control alternative to actin in western blots","volume":"401","author":"Romero-Calvo","year":"2010","journal-title":"Anal Biochem"},{"key":"2022072712532960700_ref29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2020.03.014","article-title":"Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology","volume":"94","author":"De Clercq","year":"2020","journal-title":"Placenta"},{"key":"2022072712532960700_ref30","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.placenta.2018.01.005","article-title":"Regulating needs: exploring the role of insulin-like growth factor-2 signaling in materno-fetal resource allocation","volume":"64","author":"Sferruzzi-perri","year":"2018","journal-title":"Placenta"},{"key":"2022072712532960700_ref31","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/ng.3699","article-title":"Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction","volume":"48","author":"Cleaton","year":"2016","journal-title":"Nat Genet"},{"key":"2022072712532960700_ref32","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1042\/CS20210575","article-title":"Placenta-specific Slc38a2\/SNAT2 knockdown causes fetal growth restriction in mice","volume":"135","author":"Vaughan","year":"2021","journal-title":"Clin Sci"},{"key":"2022072712532960700_ref33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/ajhb.20995","article-title":"Boys live dangerously in the womb","volume":"22","author":"Eriksson","year":"2010","journal-title":"Am J Hum Biol Off J Hum Biol Counc"},{"key":"2022072712532960700_ref34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/biolre\/ioy184","article-title":"Associations between fetal size, sex and placental angiogenesis in the pig","volume":"100","author":"Stenhouse","year":"2019","journal-title":"Biol Reprod"},{"key":"2022072712532960700_ref35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bcp.2017.09.005","article-title":"Angiogenic imbalance and diminished matrix metalloproteinase-2 and -9 underlie regional decreases in uteroplacental vascularization and feto-placental growth in hypertensive pregnancy","volume":"146","author":"Dias-Junior","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"2022072712532960700_ref36","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1152\/ajpendo.00426.2013","article-title":"Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia","volume":"306","author":"Mand\u00f2","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022072712532960700_ref37","doi-asserted-by":"crossref","first-page":"E419","DOI":"10.1152\/ajpendo.00025.2014","article-title":"Impaired mitochondrial function in human placenta with increased maternal adiposity","volume":"307","author":"Mele","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022072712532960700_ref38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.placenta.2014.06.368","article-title":"The effect of pre-existing maternal obesity and diabetes on placental mitochondrial content and electron transport chain activity","volume":"35","author":"Hastie","year":"2014","journal-title":"Placenta"},{"key":"2022072712532960700_ref39","doi-asserted-by":"crossref","first-page":"18109","DOI":"10.1073\/pnas.1907548116","article-title":"Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia","volume":"116","author":"Yung","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022072712532960700_ref40","first-page":"3903","article-title":"Expression of steroidogenic enzymes in human placenta according to the gestational age","volume":"49","author":"Hong","year":"2019","journal-title":"Mol Med Rep"},{"key":"2022072712532960700_ref41","doi-asserted-by":"crossref","first-page":"566.e1","DOI":"10.1016\/j.ajog.2008.04.020","article-title":"Differential placental gene expression in preeclampsia","volume":"199","author":"Enquobahrie","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"2022072712532960700_ref42","doi-asserted-by":"crossref","first-page":"e59609","DOI":"10.1371\/journal.pone.0059609","article-title":"Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"key":"2022072712532960700_ref43","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1210\/jc.2010-2504","article-title":"The human placenta expresses CYP17 and generates androgens de novo","volume":"96","author":"Escobar","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2022072712532960700_ref44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1439-0264.2009.00975.x","article-title":"Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes","volume":"38","author":"B\u00fcdefeld","year":"2009","journal-title":"J Vet Med Ser C Anat Histol Embryol"},{"key":"2022072712532960700_ref45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/biolre\/ioaa232","article-title":"Developmental programming of the female reproductive system - a review","volume":"104","author":"Yao","year":"2021","journal-title":"Biol Reprod"},{"key":"2022072712532960700_ref46","first-page":"1","article-title":"Testosterone decreases placental mitochondrial content and cellular bioenergetics","volume":"9","author":"Mishra","year":"2020","journal-title":"Biology (Basel)"},{"key":"2022072712532960700_ref47","doi-asserted-by":"crossref","first-page":"E794","DOI":"10.1152\/ajpendo.00359.2018","article-title":"Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production","volume":"316","author":"Hu","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022072712532960700_ref48","doi-asserted-by":"crossref","first-page":"S928","DOI":"10.1016\/j.ajog.2020.11.005","article-title":"Placental energy metabolism in health and disease\u2014significance of development and implications for preeclampsia","volume":"226","author":"Aye","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"2022072712532960700_ref49","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1089\/scd.2014.0092","article-title":"AMPK knockdown in placental trophoblast cells results in altered morphology and function","volume":"23","author":"Carey","year":"2014","journal-title":"Stem Cells Dev"},{"key":"2022072712532960700_ref50","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1113\/JP270995","article-title":"Hypoxia, AMPK activation and uterine artery vasoreactivity","volume":"594","author":"Skeffington","year":"2016","journal-title":"J Physiol"},{"key":"2022072712532960700_ref51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/jc.2012-2667","article-title":"Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies","volume":"98","author":"Jansson","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2022072712532960700_ref52","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2353\/ajpath.2008.071193","article-title":"Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction","volume":"173","author":"Yung","year":"2008","journal-title":"Am J Pathol"},{"key":"2022072712532960700_ref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-36265-8","article-title":"Mechanistic target of rapamycin complex 1 promotes the expression of genes encoding electron transport chain proteins and stimulates oxidative phosphorylation in primary human trophoblast cells by regulating mitochondrial biogenesis","volume":"9","author":"Rosario","year":"2019","journal-title":"Sci Rep"},{"key":"2022072712532960700_ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.45282","article-title":"Fetal and trophoblast PI3K p110\u03b1 have distinct roles in regulating resource supply to the growing fetus in mice","volume":"8","author":"L\u00f3pez-Tello","year":"2019","journal-title":"Elife"},{"key":"2022072712532960700_ref55","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00125-005-0054-x","article-title":"Insulin control of placental gene expression shifts from mother to foetus over the course of pregnancy","volume":"49","author":"Hiden","year":"2006","journal-title":"Diabetologia"},{"key":"2022072712532960700_ref56","doi-asserted-by":"crossref","first-page":"E1241","DOI":"10.1152\/ajpendo.00344.2006","article-title":"Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction","volume":"292","author":"Ganguly","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022072712532960700_ref57","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.placenta.2017.04.023","article-title":"Placental glucose transporter (GLUT)-1 is down-regulated in preeclampsia","volume":"55","author":"L\u00fcscher","year":"2017","journal-title":"Placenta"},{"key":"2022072712532960700_ref58","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0002-9378(99)70169-9","article-title":"Placental glucose transport and GLUT 1 expression in insulin-dependent diabetes","volume":"180","author":"Jansson","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"2022072712532960700_ref59","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1210\/jc.2012-1064","article-title":"Placental expression of peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3): relation to placental and fetal growth","volume":"97","author":"D\u00edaz","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2022072712532960700_ref60","first-page":"1","article-title":"PPAR \u03b3 stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPAR \u03b3 regulating fetal growth","author":"Chen","year":"2015","journal-title":"Nat Publ Gr"},{"key":"2022072712532960700_ref61","doi-asserted-by":"crossref","first-page":"7403230","DOI":"10.1155\/2016\/7403230","article-title":"PPARs and mitochondrial metabolism: from NAFLD to HCC","volume":"2016","author":"Mello","year":"2016","journal-title":"PPAR Res"},{"key":"2022072712532960700_ref62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.livres.2018.12.001","article-title":"Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2","volume":"2","author":"Lee","year":"2018","journal-title":"Liver Res"},{"key":"2022072712532960700_ref63","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.gene.2013.10.006","article-title":"Sexual differences of imprinted genes\u2019 expression levels","volume":"533","author":"Faisal","year":"2014","journal-title":"Gene"},{"key":"2022072712532960700_ref64","doi-asserted-by":"crossref","first-page":"dev199811","DOI":"10.1242\/dev.199811","article-title":"Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse","volume":"149","author":"Aykroyd","year":"2022","journal-title":"Development"},{"key":"2022072712532960700_ref65","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1210\/en.2011-0240","article-title":"Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice","volume":"152","author":"Sferruzzi-Perri","year":"2011","journal-title":"Endocrinology"},{"key":"2022072712532960700_ref66","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/BJ20101840","article-title":"The DLK gene is a transcriptional target of PPAR\u03b3","volume":"438","author":"Couture","year":"2011","journal-title":"Biochem J"},{"key":"2022072712532960700_ref67","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1530\/JOE-20-0128","article-title":"Igf2 deletion alters mouse placenta endocrine capacity in a sexually dimorphic manner","volume":"246","author":"Aykroyd","year":"2020","journal-title":"J Endocrinol"},{"key":"2022072712532960700_ref68","doi-asserted-by":"crossref","first-page":"106139","DOI":"10.1016\/j.anireprosci.2019.106139","article-title":"Intrauterine position and adjacent fetal sex affects fetal and placental growth throughout gestation, but not embryonic viability, in pigs selected for component traits of litter size","volume":"209","author":"Lents","year":"2019","journal-title":"Anim Reprod Sci"},{"key":"2022072712532960700_ref69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0153311","article-title":"Identification of differentially expressed genes associated with litter size in Berkshire pig placenta","volume":"11","author":"Kwon","year":"2016","journal-title":"PLoS One"},{"key":"2022072712532960700_ref70","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-4939-7614-0_14","article-title":"Assessment of placental transport function in studies of disease programming","volume":"1735","author":"Sferruzzi-Perri","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2022072712532960700_ref71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-021-02214-x","article-title":"Placental secretome characterization identifies candidates for pregnancy complications","volume":"4","author":"Napso","year":"2021","journal-title":"Commun Biol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioac056\/43350497\/ioac056.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/106\/6\/1292\/45094961\/ioac056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/106\/6\/1292\/45094961\/ioac056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T08:55:35Z","timestamp":1658912135000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/106\/6\/1292\/6549492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,16]]},"references-count":71,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3,16]]},"published-print":{"date-parts":[[2022,6,13]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioac056","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,27]]},"published":{"date-parts":[[2022,3,16]]}}}