{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T19:49:52Z","timestamp":1775850592976,"version":"3.50.1"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Science Center","award":["2017\/25\/B\/NZ9\/00040"],"award-info":[{"award-number":["2017\/25\/B\/NZ9\/00040"]}]},{"name":"Programme Interdisciplinary Doctoral Studies in Biology and Biotechnology","award":["POWR.03.05.00-00-Z310\/17"],"award-info":[{"award-number":["POWR.03.05.00-00-Z310\/17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It is well known that the body\u2019s metabolism and reproduction are closely related. Chemerin (CHEM) is one of many biologically active proteins secreted by the adipose tissue involved in the regulation of the energy homeostasis of the organism. In the present study, RNA-sequencing was performed to investigate the differentially expressed genes (DEGs), long non-coding RNAs (lncRNAs), and alternatively spliced (AS) transcripts in the cultured porcine endometrium exposed to chemerin for 24\u00a0hours (CHEM; 400\u00a0ng\/mL) collected during the implantation period (15\u201316\u00a0days of gestation). High-throughput sequencing of transcriptomes was performed on the Illumina NovaSeq 6000 platform (Illumina, USA). In the current study, among all 130 DEGs, 58 were upregulated and 72 were downregulated in the CHEM-treated group. DEGs were assigned to 73 functional annotations. Twelve identified lncRNAs indicated a difference in the expression profile after CHEM administration. Additionally, we detected 386 differentially AS events encompassed 274 protein-coding genes and 2 lncRNAs. All AS events were divided into five alternative splicing types: alternative 3\u2032 splice site (A3SS), 5\u2032 splice site (A5SS), mutually exclusive exons (MXE), retention intron (RI), and skipping exon (SE). Within all AS events, we identified 42 A3SS, 43 A5SS, 53 MXE, 9 RI, and 239 SE. In summary, CHEM affects the transcriptomic profile of the porcine endometrium, controlling the expression of numerous genes, including those involved in the cell migration and adhesion, angiogenesis, inflammation, and steroidogenesis. It can be assumed that CHEM may be an important factor for a proper course of gestation and embryo development.<\/jats:p>","DOI":"10.1093\/biolre\/ioac063","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T18:02:33Z","timestamp":1648576953000},"page":"557-573","source":"Crossref","is-referenced-by-count":13,"title":["Chemerin effect on transcriptome of the porcine endometrium during implantation determined by RNA-sequencing"],"prefix":"10.1093","volume":"107","author":[{"given":"Kinga","family":"Orzechowska","sequence":"first","affiliation":[{"name":"Department of Animal Anatomy and Physiology , Faculty of Biology and Biotechnology, , Olsztyn, Poland"},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Kopij","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology , Faculty of Biology and Biotechnology, , Olsztyn, Poland"},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Paukszto","sequence":"additional","affiliation":[{"name":"Department of Botany and Nature Protection , Faculty of Biology and Biotechnology, , Olsztyn, Poland"},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Dobrzyn","sequence":"additional","affiliation":[{"name":"Department of Zoology , Faculty of Biology and Biotechnology, , Olsztyn, Poland"},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Kiezun","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology , Faculty of Biology and Biotechnology, , Olsztyn, Poland"},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Jastrzebski","sequence":"additional","affiliation":[{"name":"Department of Plant Physiology , Genetics and Biotechnology, Faculty of Biology and Biotechnology, , Olsztyn, Poland"},{"name":"University of Warmia and Mazury in Olsztyn , Genetics and Biotechnology, Faculty of Biology and Biotechnology, , Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology , Faculty of Biology and Biotechnology, , Olsztyn, Poland"},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Smolinska","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology , Faculty of Biology and Biotechnology, , Olsztyn, Poland"},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"2022081707382706500_ref1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1095\/biolreprod27.4.941","article-title":"Establishment of pregnancy in the pig: II. 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