{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:32:33Z","timestamp":1769754753230,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0107702"],"award-info":[{"award-number":["2018YFA0107702"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970785"],"award-info":[{"award-number":["31970785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170855"],"award-info":[{"award-number":["32170855"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fanconi anemia complementation group B (FANCB) protein is a major component of the Fanconi anemia (FA) core complex and plays an important role in hematopoiesis and germ cell development. Deletion of Fancb gene causes the defect of primordial germ cell (PGC) development and infertility in male mice. However, it remains unknown whether Fancb is required for female germ cell development. In this study, we found that the fertility of Fancb knockout male mice in C57\/ICR mixed backgrounds was not affected. Female Fancb\u2212\/\u2212 mice were obtained by crossing Fancb+\/\u2212 females with Fancb\u2212\/Y males. The number of PGCs was dramatically decreased in Fancb\u2212\/\u2212 females. Very few oocytes were observed after birth and the primordial follicle pool was completely depleted at 6\u00a0weeks of age in Fancb\u2212\/\u2212 females. However, the remained oocytes from Fancb\u2212\/\u2212 mice were normal in fertilization and embryonic development from 2-cell to the blastocyst stage. We also found that Fancb and Fancl double-knockout males were also fertile and the number of sperm in epididymis was not reduced as compared to that of Fancb\u2212\/\u2212 and Fancl\u2212\/\u2212 single-knockout mice. Taken together, these results showed that Fancb is also essential for female germ cell development. Inactivation of Fancb causes massive germ cell loss and infertility in adult females. We also found that Fancb and Fancl do not act synergistically in regulating germ cell development.<\/jats:p>","DOI":"10.1093\/biolre\/ioac103","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T03:59:50Z","timestamp":1653105590000},"page":"790-799","source":"Crossref","is-referenced-by-count":9,"title":["<i>Fancb<\/i> deficiency causes premature ovarian insufficiency in mice"],"prefix":"10.1093","volume":"107","author":[{"given":"Changhuo","family":"Cen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing , China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing , China"},{"name":"University of Chinese Academy of Sciences , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Zunyi Medical University , Zunyi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Lin","sequence":"additional","affiliation":[{"name":"National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing , China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing , China"},{"name":"University of Chinese Academy of Sciences , Beijing , China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing , China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing , China"},{"name":"University of Chinese Academy of Sciences , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing , China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing , China"},{"name":"University of Chinese Academy of Sciences , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhong","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing , China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Zunyi Medical University , Zunyi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing , China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing , China"},{"name":"University of Chinese Academy of Sciences , Beijing , China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"2022091511313677700_ref1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrm.2016.48","article-title":"The fanconi anaemia pathway: ew players and new functions","volume":"17","author":"Ceccaldi","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2022091511313677700_ref2","doi-asserted-by":"crossref","first-page":"652407","DOI":"10.3389\/fcell.2021.652407","article-title":"Meiotic recombination defects and premature ovarian insufficiency","volume":"9","author":"Huang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2022091511313677700_ref3","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1126\/science.1182372","article-title":"The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link 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