{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:41:28Z","timestamp":1768808488122,"version":"3.49.0"},"reference-count":249,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006595","name":"UEFISCDI","doi-asserted-by":"publisher","award":["544PED\/2020"],"award-info":[{"award-number":["544PED\/2020"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the recent years a special attention has been given to a major health concern namely to male infertility, defined as the inability to conceive after 12\u00a0months of regular unprotected sexual intercourse, taken into account the statistics that highlight that sperm counts have dropped by 50\u201360% in recent decades. According to the WHO, infertility affects approximately 9% of couples globally, and the male factor is believed to be present in roughly 50% of cases, with exclusive responsibility in 30%. The aim of this article is to present an evidence-based approach for diagnosing male infertility that includes finding new solutions for diagnosis and critical outcomes, retrieving up-to-date studies and existing guidelines. The diverse factors that induce male infertility generated in a vast amount of data that needed to be analyzed by a clinician before a decision could be made for each individual. Modern medicine faces numerous obstacles as a result of the massive amount of data generated by the molecular biology discipline. To address complex clinical problems, vast data must be collected, analyzed, and used, which can be very challenging. The use of artificial intelligence (AI) methods to create a decision support system can help predict the diagnosis and guide treatment for infertile men, based on analysis of different data as environmental and lifestyle, clinical (sperm count, morphology, hormone testing, karyotype, etc.), and \u201comics\u201d bigdata. Ultimately, the development of AI algorithms will assist clinicians in formulating diagnosis, making treatment decisions, and predicting outcomes for assisted reproduction techniques.<\/jats:p>","DOI":"10.1093\/biolre\/ioac105","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T19:21:15Z","timestamp":1653074475000},"page":"684-704","source":"Crossref","is-referenced-by-count":7,"title":["Advanced molecular approaches in male infertility diagnosis"],"prefix":"10.1093","volume":"107","author":[{"given":"A","family":"Botezatu","sequence":"first","affiliation":[{"name":"Molecular Virology Department, \u201cStefan S. Nicolau\u201d Institute of Virology , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Vladoiu","sequence":"additional","affiliation":[{"name":"Research Laboratory in Molecular , Cellular and Structural Endocrinology, , Bucharest , Romania"},{"name":"\u201cCI Parhon\u201d National Institute of Endocrinology , Cellular and Structural Endocrinology, , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Fudulu","sequence":"additional","affiliation":[{"name":"Molecular Virology Department, \u201cStefan S. Nicolau\u201d Institute of Virology , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Albulescu","sequence":"additional","affiliation":[{"name":"Molecular Virology Department, \u201cStefan S. Nicolau\u201d Institute of Virology , Bucharest , Romania"},{"name":"Pharmacology Department, National Institute for Chemical Pharmaceutical Research & Development , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Plesa","sequence":"additional","affiliation":[{"name":"Molecular Virology Department, \u201cStefan S. Nicolau\u201d Institute of Virology , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Muresan","sequence":"additional","affiliation":[{"name":"Research Laboratory in Molecular , Cellular and Structural Endocrinology, , Bucharest , Romania"},{"name":"\u201cCI Parhon\u201d National Institute of Endocrinology , Cellular and Structural Endocrinology, , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Stancu","sequence":"additional","affiliation":[{"name":"Research Laboratory in Molecular , Cellular and Structural Endocrinology, , Bucharest , Romania"},{"name":"\u201cCI Parhon\u201d National Institute of Endocrinology , Cellular and Structural Endocrinology, , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I V","family":"Iancu","sequence":"additional","affiliation":[{"name":"Molecular Virology Department, \u201cStefan S. Nicolau\u201d Institute of Virology , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C C","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Molecular Virology Department, \u201cStefan S. Nicolau\u201d Institute of Virology , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Velicu","sequence":"additional","affiliation":[{"name":"Research Laboratory in Molecular , Cellular and Structural Endocrinology, , Bucharest , Romania"},{"name":"\u201cCI Parhon\u201d National Institute of Endocrinology , Cellular and Structural Endocrinology, , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O M","family":"Popa","sequence":"additional","affiliation":[{"name":"Research Laboratory in Molecular , Cellular and Structural Endocrinology, , Bucharest , Romania"},{"name":"\u201cCI Parhon\u201d National Institute of Endocrinology , Cellular and Structural Endocrinology, , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Badiu","sequence":"additional","affiliation":[{"name":"Research Laboratory in Molecular , Cellular and Structural Endocrinology, , Bucharest , Romania"},{"name":"\u201cCI Parhon\u201d National Institute of Endocrinology , Cellular and Structural Endocrinology, , Bucharest , Romania"},{"name":"Endocrinology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Dinu-Draganescu","sequence":"additional","affiliation":[{"name":"Research Laboratory in Molecular , Cellular and Structural Endocrinology, , Bucharest , Romania"},{"name":"\u201cCI Parhon\u201d National Institute of Endocrinology , Cellular and Structural Endocrinology, , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"2022091511333855000_ref1","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.17076.1","article-title":"Recent advances in understanding and managing male infertility","volume":"8","author":"Fainberg","year":"2019","journal-title":"F1000Res"},{"key":"2022091511333855000_ref2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ucl.2013.08.006","article-title":"The epidemiology of male infertility","volume":"41","author":"Winters","year":"2014","journal-title":"Urol Clin North Am"},{"key":"2022091511333855000_ref3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/bmj.305.6854.609","article-title":"Evidence for decreasing quality of semen during past 50 years","volume":"305","author":"Carlsen","year":"1992","journal-title":"BMJ"},{"key":"2022091511333855000_ref4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/13625180410001715681","article-title":"Contraceptive use and behavior in the 21st century: a comprehensive study across five European countries","volume":"9","author":"Skouby","year":"2004","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"2022091511333855000_ref5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2605.2005.00573.x","article-title":"Is human fecundity declining?","volume":"29","author":"Skakkeb\u00e6k","year":"2006","journal-title":"Int J Andrl"},{"key":"2022091511333855000_ref6","first-page":"641","article-title":"Male infertility-the other side of the equation","volume":"46","author":"Katz","year":"2017","journal-title":"Aust Fam Physician"},{"key":"2022091511333855000_ref7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(20)32667-2","article-title":"Male infertility","volume":"397","author":"Agarwal","year":"2021","journal-title":"Lancet"},{"key":"2022091511333855000_ref8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.eururo.2005.06.002","article-title":"EAU working group on male infertility. 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