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The treatment of PCOS mainly focuses on improving clinical symptoms, such as insulin sensitivity or menstrual disorder, through drug treatment. However, due to the pathogenesis diversity of PCOS, there is still a lack of effective treatment in clinics. Metabolic disorder is the key factor in the occurrence of PCOS. Brown adipose tissue (BAT) is a special adipose tissue in the human body that can participate in metabolic balance by improving heat production. BAT has been demonstrated to be an important substance involved in the metabolic disorder of PCOS. Although increasing evidence indicates that BAT transplantation can improve the symptoms of PCOS, it is difficult to achieve BAT transplantation at present due to technical limitations. Stimulation of BAT activation by exogenous substances may be an effective alternative therapy for PCOS. In this study, we investigated the effects of Irisin on dehydroepiandrosterone (DHEA)-induced PCOS in mice and evaluated the effect of Irisin on serum hormone levels and changes in body temperature, body weight, and ovarian morphology. In our study, we found that Irisin can enhance the thermogenesis and insulin sensitivity of PCOS mice by activating the function of BAT. In addition, Irisin treatment can correct the menstrual cycle of PCOS mice, improve the serum steroid hormone disorder status, and reduce the formation of ovarian cystic follicles. In conclusion, our results showed that Irisin treatment significantly improved the metabolic disorder of PCOS and may provide a new and alternative therapy for the treatment of this pathology.<\/jats:p>","DOI":"10.1093\/biolre\/ioac125","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T11:12:54Z","timestamp":1655464374000},"source":"Crossref","is-referenced-by-count":12,"title":["Irisin reduces the abnormal reproductive and metabolic phenotypes of PCOS by regulating the activity of brown adipose tissue in mice"],"prefix":"10.1093","author":[{"given":"Yajing","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ultrasound , Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pain , Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Renmin Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"2022070305561797200_ref1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"2022070305561797200_ref2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian Hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr Rev"},{"key":"2022070305561797200_ref3","doi-asserted-by":"crossref","first-page":"E3334","DOI":"10.1073\/pnas.1616467114","article-title":"Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome","volume":"114","author":"Caldwell","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022070305561797200_ref4","doi-asserted-by":"crossref","first-page":"116940","DOI":"10.1016\/j.lfs.2019.116940","article-title":"Hyperandrogenemia and insulin resistance: the chief culprit of polycystic ovary syndrome","volume":"236","author":"Wang","year":"2019","journal-title":"Life Sci"},{"key":"2022070305561797200_ref5","doi-asserted-by":"crossref","first-page":"D1","DOI":"10.1530\/EJE-18-0237","article-title":"Diagnosis and follow-up of type 2 diabetes in women with PCOS: a role for OGTT?","volume":"179","author":"Andersen","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"2022070305561797200_ref6","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1097\/AOG.0000000000002656","article-title":"ACOG Practice bulletin no. 194: polycystic ovary syndrome","volume":"131","author":"American College of, O. and B.-G. 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