{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:30:07Z","timestamp":1777696207659,"version":"3.51.4"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2020-MS-153"],"award-info":[{"award-number":["2020-MS-153"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Controlled ovarian stimulation (COS) is a major component of assisted reproductive technologies. Clinically, it has been observed that some women experience changes in thyrotropin levels following COS, which then bring about subclinical hypothyroidism and may adversely affect conception. Studies have also shown that the specific degree as well as the tendency of changes in thyroid function vary with differences in thyroid function before pregnancy, thyroid autoimmunity, the COS regimen, and the observation time point. However, the associated pathophysiological mechanism of the effects of COS on pregnancy has not yet been fully elucidated. This may be because increased estradiol levels, caused by COS, induce increased levels of thyroxine-binding globulin, resulting in a decrease in free thyroxine (FT4) level and an increase in TSH level. Conversely, it has also been observed that human chorionic gonadotropin (hCG) can act directly on thyroid cells, exerting opposite effects on FT4 and TSH levels. Additionally, the effects of COS on thyroid function may be more pronounced, especially in women with autoimmune thyroid disease or thyroid dysfunction before pregnancy, ultimately leading to subclinical hypothyroidism. Here, we review recent research progress regarding the effects of COS on thyroid function during pregnancy.<\/jats:p>","DOI":"10.1093\/biolre\/ioac159","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T21:10:20Z","timestamp":1660338620000},"page":"1376-1385","source":"Crossref","is-referenced-by-count":2,"title":["Effects of controlled ovarian stimulation on thyroid function during pregnancy"],"prefix":"10.1093","volume":"107","author":[{"given":"Lingfei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Shengjing Hospital of China Medical University , Shenyang, Liaoning Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shengjing Hospital of China Medical University , Shenyang, Liaoning Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shengjing Hospital of China Medical University , Shenyang, Liaoning Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"2022121508042403700_ref1","first-page":"CD010537","article-title":"Assisted reproductive technology: an overview of Cochrane reviews","author":"Farquhar","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2022121508042403700_ref2","first-page":"CD010537","article-title":"Assisted reproductive technology: an overview of Cochrane reviews","volume":"2018","author":"Farquhar","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"2022121508042403700_ref3","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/jama.2019.10931","article-title":"Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis","volume":"322","author":"Consortium on T","year":"2019","journal-title":"JAMA"},{"key":"2022121508042403700_ref4","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1089\/thy.2013.0022","article-title":"Impaired outcome of controlled ovarian hyperstimulation in women with thyroid autoimmune disease","volume":"23","author":"Magri","year":"2013","journal-title":"Thyroid"},{"key":"2022121508042403700_ref5","doi-asserted-by":"crossref","first-page":"e0175708","DOI":"10.1371\/journal.pone.0175708","article-title":"Patients with subclinical hypothyroidism before 20 weeks of pregnancy have a higher risk of miscarriage: a systematic review and meta-analysis","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"key":"2022121508042403700_ref6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/09513590.2019.1653564","article-title":"Does subclinical hypothyroidism and\/or thyroid autoimmunity influence the IVF\/ICSI outcome? 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