{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:17:19Z","timestamp":1773789439526,"version":"3.50.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R00-HD096051"],"award-info":[{"award-number":["R00-HD096051"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Morphogenesis of the female reproductive tract is regulated by the mesenchyme. However, the identity of the mesenchymal lineage that directs the morphogenesis of the female reproductive tract has not been determined. Using in vivo genetic cell ablation, we identified Amhr2+ mesenchyme as an essential mesenchymal population in patterning the female reproductive tract. After partial ablation of Amhr2+ mesenchymal cells, the oviduct failed to develop its characteristic coiling due to decreased epithelial proliferation and tubule elongation during development. The uterus displayed a reduction in size and showed decreased cellular proliferation in both epithelial and mesenchymal compartments. More importantly, in the uterus, partial ablation of Amhr2+ mesenchyme caused abnormal lumen shape and altered the direction of its long axis from the dorsal-ventral axis to the left\u2013right axis (i.e., perpendicular to the dorsal-ventral axis). Despite these morphological defects, epithelia underwent normal differentiation into secretory and ciliated cells in the oviduct and glandular epithelial cells in the uterus. These results demonstrated that Amhr2+ mesenchyme can direct female reproductive tract morphogenesis by regulating epithelial proliferation and lumen shape without affecting the differentiation of epithelial cell types.<\/jats:p>","DOI":"10.1093\/biolre\/ioac179","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T20:35:43Z","timestamp":1663792543000},"page":"1477-1489","source":"Crossref","is-referenced-by-count":5,"title":["Morphogenesis of the female reproductive tract along antero-posterior and dorso-ventral axes is dependent on <i>Amhr2+<\/i> mesenchyme in mice"],"prefix":"10.1093","volume":"107","author":[{"given":"Shuai","family":"Jia","sequence":"first","affiliation":[{"name":"University of Wisconsin-Madison Department of Comparative Biosciences, School of Veterinary Medicine, , Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian","family":"Wilbourne","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison Department of Comparative Biosciences, School of Veterinary Medicine, , Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"McKenna J","family":"Crossen","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison Department of Comparative Biosciences, School of Veterinary Medicine, , Madison, WI, USA"},{"name":"University of Wisconsin-Madison Endocrinology and Reproductive Physiology Program, , Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison Department of Comparative Biosciences, School of Veterinary Medicine, , Madison, WI, USA"},{"name":"University of Wisconsin-Madison Endocrinology and Reproductive Physiology Program, , 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