{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:09:35Z","timestamp":1780344575179,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000052","name":"Office of the NIH Director","doi-asserted-by":"publisher","award":["P51 OD011092"],"award-info":[{"award-number":["P51 OD011092"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 HD071836"],"award-info":[{"award-number":["P50 HD071836"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polycystic ovary syndrome (PCOS) is associated with irregular menstrual cycles, hyperandrogenemia, and obesity. It is currently accepted that women with PCOS are also at risk for endometriosis, but the effect of androgen and obesity on endometriosis has been underexplored. The goal of this study was to determine how testosterone (T) and an obesogenic diet impact the progression of endometriosis in a nonhuman primate (NHP) model. Female rhesus macaques were treated with T (serum levels approximately 1.35\u00a0ng\/ml), Western-style diet (WSD; 36% of calories from fat compared to 16% in standard monkey chow) or the combination (T\u2009+\u2009WSD) at the time of menarche as part of a longitudinal study for ~7\u00a0years. Severity of endometriosis was determined based on American Society for Reproductive Medicine (ASRM) revised criteria, and staged 1\u20134. Stages 1 and 2 were associated with extent of abdominal adhesions, while stages 3 and 4 were associated with presence of chocolate cysts. The combined treatment of T\u2009+\u2009WSD resulted in earlier onset of endometriosis and more severe types associated with large chocolate cysts compared to all other treatments. There was a strong correlation between glucose clearance, homeostatic model assessment for insulin resistance (HOMA-IR), and total percentage of body fat with presence of cysts, indicating possible indirect contribution of hyperandrogenemia via metabolic dysfunction. An RNA-seq analysis of omental adipose tissue revealed significant impacts on a number of inflammatory signaling pathways. The interactions between obesity, hyperandrogenemia, and abdominal inflammation deserve additional investigation in NHP model species.<\/jats:p>","DOI":"10.1093\/biolre\/ioac183","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T18:39:28Z","timestamp":1664476768000},"page":"72-80","source":"Crossref","is-referenced-by-count":17,"title":["The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques"],"prefix":"10.1093","volume":"108","author":[{"given":"Cecily V","family":"Bishop","sequence":"first","affiliation":[{"name":"Oregon National Primate Research Center, Oregon Health & Science University Division of Reproductive and Developmental Sciences, , Beaverton, Oregon , USA"},{"name":"College of Agricultural Sciences, Oregon State University Department of Animal and Rangeland Sciences, , Corvallis, Oregon , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana 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D","family":"Slayden","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center, Oregon Health & Science University Division of Reproductive and Developmental Sciences, , Beaverton, Oregon , USA"},{"name":"Oregon Health & Science University Department of Obstetrics & Gynecology, , Portland, Oregon , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"issue":"451","key":"2023011710451215900_ref1","first-page":"e451","article-title":"Risk factors associated with endometriosis: importance of study population for characterizing disease in the ENDO study","volume":"208","author":"Peterson","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"2023011710451215900_ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12905-020-01139-7","article-title":"Real-world characteristics of women with endometriosis-related pain entering a multidisciplinary 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