{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:35:02Z","timestamp":1772138102927,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R017522\/1"],"award-info":[{"award-number":["BB\/R017522\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Environmental stressors to which a fetus is exposed affect a range of physiological functions in postnatal offspring. We aimed to determine the in utero effect of steroid hormones on the reproductive potential of female offspring using a porcine model. Reproductive tracts of pigs from female-biased (&amp;gt;65% female, n\u2009=\u200915), non-biased (45\u201354.9% female, n\u2009=\u200915), and male-biased litters (&amp;lt;35% females, n\u2009=\u20099) were collected at slaughter (95\u2013115\u00a0kg). Ovaries and uterine horns were processed for H&amp;E or immunohistochemistry. Variability of data within groups was analyzed with a Levene\u2019s test, while data were analyzed using mixed linear models in R. In the ovarian reserve, there was a significant birth weight by sex ratio interaction (P\u2009=\u20090.015), with low birth weight pigs from male-biased litters having higher numbers of primordial follicles with opposite trends seen in pigs from female-biased litters. Sex bias held no effect on endometrial gland development. A lower birth weight decreased the proportion of glands found in the endometrium (P\u2009=\u20090.045) and was more variable in both male-biased and female-biased litters (P\u2009=\u20090.026). The variability of primordial follicles from male-biased litters was greater than non- and female-biased litters (P\u2009=\u20090.014). Similarly, endometrial stromal nuclei had a greater range in male- and female-biased litters than non-biased litters (P\u2009=\u20090.028). A crucial finding was the greater variability in primordial follicles in the ovaries from females derived from male-biased litters and stromal cell count in the endometrium of females from male- and female-biased litters. This could be inflating the variability of reproductive success seen in females from male-biased litters.<\/jats:p>","DOI":"10.1093\/biolre\/ioac208","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T08:01:15Z","timestamp":1668672075000},"page":"304-315","source":"Crossref","is-referenced-by-count":3,"title":["Sex bias in utero alters ovarian reserve but not uterine capacity in female offspring"],"prefix":"10.1093","volume":"108","author":[{"given":"Annika V","family":"Geijer-Simpson","sequence":"first","affiliation":[{"name":"Discovery and Translational Sciences Department, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK"},{"name":"School of Biology, Faculty of Biological Sciences, University of Leeds , Leeds , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidee","family":"Tinning","sequence":"additional","affiliation":[{"name":"Discovery and Translational Sciences Department, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago H C","family":"De Bem","sequence":"additional","affiliation":[{"name":"Discovery and Translational Sciences Department, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Tsagakis","sequence":"additional","affiliation":[{"name":"Discovery and Translational Sciences Department, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alysha S","family":"Taylor","sequence":"additional","affiliation":[{"name":"Discovery and Translational Sciences Department, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Hume","sequence":"additional","affiliation":[{"name":"Discovery and Translational Sciences Department, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M","family":"Collins","sequence":"additional","affiliation":[{"name":"School of Biology, Faculty of Biological Sciences, University of Leeds , Leeds , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"Forde","sequence":"additional","affiliation":[{"name":"Discovery and Translational Sciences Department, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , 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