{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:43:50Z","timestamp":1783950230902,"version":"3.55.0"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["USDA 1013511"],"award-info":[{"award-number":["USDA 1013511"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Obese women are subfertile and have reduced assisted reproduction success, which may be due to reduced oocyte competence. We hypothesize that consumption of a high-fat\/high-sugar diet induces ovarian inflammation, which is a primary contributor to decreased oocyte quality and pre-implantation embryo development. To test this hypothesis, C57BL\/6 (B6) mice with a normal inflammatory response and C3H\/HeJ (C3H) mice with a dampened inflammatory response due to dysfunctional Toll-like receptor 4 were fed either normal chow or high-fat\/high-sugar diet. In both B6 and C3H females, high-fat\/high-sugar diet induced excessive adiposity and hyperglycemia compared to normal chow-fed counterparts. Conversely, ovarian CD68 levels and oocyte expression of oxidative stress markers were increased when collected from B6 high-fat\/high-sugar but not C3H high-fat\/high-sugar mice. Following in vitro fertilization of in vivo matured oocytes, blastocyst development was decreased in B6-high-fat\/high-sugar but not C3H high-fat\/high-sugar mice. Expression of cumulus cell markers of oocyte quality were altered in both B6 high-fat\/high-sugar and C3H high-fat\/high-sugar. However, there were no diet-dependent differences in spindle abnormalities in either B6 or C3H mice, suggesting potential defects in cytoplasmic maturation. Indeed, there were significant increases in the abundance of maternal effect gene mRNAs in oocytes from only B6 high-fat\/high-sugar mice. These differentially expressed genes encode proteins of the subcortical maternal complex and associated with mRNA metabolism and epigenetic modifications. These genes regulate maternal mRNA degradation at oocyte maturation, mRNA clearance at the zygotic genome activation, and methylation of imprinted genes suggesting a mechanism by which inflammation induced oxidative stress impairs embryo development.<\/jats:p>","DOI":"10.1093\/biolre\/ioac212","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T14:23:30Z","timestamp":1670077410000},"page":"423-436","source":"Crossref","is-referenced-by-count":7,"title":["Ovarian inflammation mediated by Toll-like receptor 4 increased transcripts of maternal effect genes and decreased embryo development"],"prefix":"10.1093","volume":"108","author":[{"given":"Alison F","family":"Ermisch","sequence":"first","affiliation":[{"name":"University of Nebraska-Lincoln Department of Animal Science, , Lincoln, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L","family":"Bidne","sequence":"additional","affiliation":[{"name":"University of Nebraska-Lincoln Department of Animal Science, , Lincoln, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott G","family":"Kurz","sequence":"additional","affiliation":[{"name":"University of Nebraska-Lincoln Department of Animal Science, , Lincoln, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri A","family":"Bochantin","sequence":"additional","affiliation":[{"name":"University of Nebraska-Lincoln Department of Animal Science, , Lincoln, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R","family":"Wood","sequence":"additional","affiliation":[{"name":"University of Nebraska-Lincoln Department of Animal Science, , Lincoln, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"2023120301074222900_ref1","first-page":"1\u20138","article-title":"Prevalence of obesity and severe obesity among adults: United 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