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Myeloid-derived suppressor cells are myeloid progenitor cells with immunosuppressive activities on both innate and adaptive cells through various mechanisms. Emerging evidence demonstrates the accumulation of myeloid-derived suppressor cells during healthy pregnancy to establish maternal\u2013fetal immune tolerance, placentation, and fetal\u2013growth process. By contrast, the absence or decreased myeloid-derived suppressor cells in pregnancy complications like preeclampsia, preterm birth, stillbirth, and recurrent spontaneous abortion have been reported. Here, we have summarized the origin, mechanisms, and functions of myeloid-derived suppressor cells during pregnancy along with the recent advancements in this dynamic field. We also shed light on the immunomodulatory activity of myeloid-derived suppressor cells, which can be a foundation for potential therapeutic manipulation in immunological pregnancy complications.<\/jats:p>","DOI":"10.1093\/biolre\/ioac213","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T11:38:20Z","timestamp":1670845100000},"page":"382-392","source":"Crossref","is-referenced-by-count":14,"title":["MDSCs in pregnancy and pregnancy-related complications: an update"],"prefix":"10.1093","volume":"108","author":[{"given":"Neelam Kumari","family":"Shah","sequence":"first","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Shan","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xie","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizi","family":"Meng","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Shu","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Dong","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"},{"name":"The First Hospital of Jilin University, Jilin University Key Laboratory of Organ Regeneration & Transplantation of Ministry of Education, National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin University Department of Obstetrics, Obstetrics and Gynaecology Center, , Changchun, China"},{"name":"The First Hospital of Jilin University, Jilin University Key Laboratory of Organ Regeneration & Transplantation of Ministry of Education, National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"2023031502353610300_","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-immunol-032712-100003","article-title":"Immunology of the maternal-fetal interface","volume":"31","author":"Erlebacher","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2023031502353610300_","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ni.3131","article-title":"Immune mechanisms at the maternal-fetal interface: perspectives and challenges","volume":"16","author":"PrabhuDas","year":"2015","journal-title":"Nat Immunol"},{"key":"2023031502353610300_","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.yhbeh.2012.02.023","article-title":"Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis","volume":"62","author":"Robinson","year":"2012","journal-title":"Horm 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