{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:28:20Z","timestamp":1793363300146,"version":"4.5.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["31003A_182481"],"award-info":[{"award-number":["31003A_182481"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glucocorticoids modulate the feto-maternal interface during the induction of parturition. In the dog, the prepartum rise of cortisol in the maternal circulation appears to be erratic, and information about its contribution to the prepartum luteolytic cascade is scarce. However, the local placental upregulation of glucocorticoid receptor (GR\/NR3C1) at term led to the hypothesis that species-specific regulatory mechanisms might apply to the involvement of cortisol in canine parturition. Therefore, here, we assessed the canine uterine\/utero-placental spatio-temporal expression of hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1; reduces cortisone to cortisol), and -2 (HSD11B2; oxidizes cortisol to the inactive cortisone). Both enzymes were detectable throughout pregnancy. Their transcriptional levels were elevated following implantation, with a strong increase in HSD11B2 post-implantation (days 18\u201325 of pregnancy), and in HSD11B1 at mid-gestation (days 35\u201340) (P\u2009&amp;lt;\u20090.05). Interestingly, when compared pairwise, HSD11B2 transcripts were higher during post-implantation, whereas HSD11B1 dominated during mid-gestation and luteolysis (P\u2009&amp;lt;\u20090.05). A custom-made species-specific antibody generated against HSD11B2 confirmed its decreased expression at prepartum luteolysis. Moreover, in mid-pregnant dogs treated with aglepristone, HSD11B1 was significantly higher than \u22122 (P\u2009&amp;lt;\u20090.05). HSD11B2 (protein and transcript) was localized mostly in the syncytiotrophoblast, whereas HSD11B1 mRNA was mainly localized in cytotrophoblast cells. Finally, in a functional approach using placental microsomes, a reduced conversion capacity to deactivate cortisol into cortisone was observed during prepartum luteolysis, fitting well with the diminished HSD11B2 levels. In particular, the latter findings support the presence of local increased cortisol availability at term in the dog, contrasting with an enhanced inactivation of cortisol during early pregnancy.<\/jats:p>","DOI":"10.1093\/biolre\/ioac214","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:21:54Z","timestamp":1675275714000},"page":"645-658","source":"Crossref","is-referenced-by-count":12,"title":["Utero-placental expression and functional implications of HSD11B1 and HSD11B2 in canine pregnancy"],"prefix":"10.1093","volume":"108","author":[{"given":"Miguel","family":"Tavares Pereira","sequence":"first","affiliation":[{"name":"Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schuler","sequence":"additional","affiliation":[{"name":"Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University , Giessen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Near East University , Nicosia , Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Payan-Carreira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, School of Science and Technology, University of \u00c9vora , \u00c9vora , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris M","family":"Reichler","sequence":"additional","affiliation":[{"name":"Clinic for Reproductive Medicine, Vetsuisse Faculty, University of Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Reynaud","sequence":"additional","affiliation":[{"name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, EnvA , Maisons-Alfort , France"},{"name":"Physiologie de la Reproduction et des Comportements, CNRS, IFCE, INRAE, Universit\u00e9 de Tours, PRC , Nouzilly , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz P","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich , Zurich , Switzerland"},{"name":"Center for Clinical Studies, Vetsuisse Faculty, University of Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"2023041705193609700_","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1095\/biolreprod64.4.1019","article-title":"Glucocorticoid regulation of human and ovine parturition: the relationship between fetal hypothalamic-pituitary-adrenal axis activation and intrauterine prostaglandin production","volume":"64","author":"Whittle","year":"2001","journal-title":"Biol Reprod"},{"key":"2023041705193609700_","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/neuro.08.019.2009","article-title":"Prenatal stress, glucocorticoids and the programming of adult disease","volume":"3","author":"Cottrell","year":"2009","journal-title":"Front Behav Neurosci"},{"key":"2023041705193609700_","first-page":"111","article-title":"The mechanism of initiation of parturition in the ewe","volume":"29","author":"Liggins","year":"1973","journal-title":"Recent Prog Horm Res"},{"key":"2023041705193609700_","doi-asserted-by":"crossref","first-page":"822","DOI":"10.21451\/1984-3143-AR2018-0015","article-title":"Placental contribution to the endocrinology of gestation and parturition","volume":"15","author":"Schuler","year":"2018","journal-title":"Anim Reprod"},{"key":"2023041705193609700_","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0002-9378(72)90185-8","article-title":"Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. 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