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Dysfunction of trophoblasts may cause a series of pregnancy complications, including preeclampsia, fetal growth restriction, and RPL. Recently, lncRNAs have been found to be closely related to the occurrence and regulation of pregnancy-related diseases, but few studies have focused on their role in RPL. In this study, we identified a novel lncRNA BBOX1-AS1 that was significantly upregulated in villous tissues and serum of RPL patients. Functionally, BBOX1-AS1 inhibited proliferation, migration, invasion, tube formation and promoted apoptosis of trophoblast cells. Mechanistically, overexpression of BBOX1-AS1 activated the p38 and JNK MAPK signaling pathways by upregulating GADD45A expression. Further studies indicated that BBOX1-AS1 could increase the stability of GADD45A mRNA by binding hnRNPK and ultimately cause abnormal trophoblast function. Collectively, our study highlights that the BBOX1-AS1\/hnRNPK\/GADD45A axis plays an important role in trophoblast-induced RPL and that BBOX1-AS1 may serve as a potential target for the diagnosis of RPL.<\/jats:p>","DOI":"10.1093\/biolre\/ioad002","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T06:04:00Z","timestamp":1673157840000},"page":"408-422","source":"Crossref","is-referenced-by-count":13,"title":["BBOX1-AS1 mediates trophoblast cells dysfunction via regulating hnRNPK\/GADD45A axis"],"prefix":"10.1093","volume":"108","author":[{"given":"Yali","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Shandong University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Shandong University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Shandong University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Shandong University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Shandong University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Shandong University , Jinan, Shandong , 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