{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:57:40Z","timestamp":1772578660694,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD044858"],"award-info":[{"award-number":["HD044858"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32HD007263-38"],"award-info":[{"award-number":["5T32HD007263-38"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reproductive longevity is associated with health outcomes. Early menopause, loss of ovarian function, and male infertility are linked to shorter lifespan and increased adverse health outcomes. Here we examined the extragonadal effects of whole animal loss of spermatogenesis and oogenesis specific basic helix\u2013loop\u2013helix 1 (Sohlh1) gene in mice, a well-described mouse model of female and male infertility. Sohlh1 encodes a transcription factor that is primarily expressed in the male and female germline and regulates germline differentiation. The Sohlh1 knockout mouse model, just like human individuals with SOHLH1 loss of function, presents with hypergonadotropic hypogonadism and loss of ovarian function in females and impaired spermatogenesis in males, with a seemingly gonad restricted phenotype in both sexes. However, extragonadal phenotyping revealed that Sohlh1 deficiency leads to abnormal immune profiles in the blood and ovarian tissues of female animals, sex-specific alterations of metabolites, and behavior and cognition changes. Altogether, these results show that Sohlh1 deficiency impacts overall health in both male and female mice.<\/jats:p>","DOI":"10.1093\/biolre\/ioad008","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:21:29Z","timestamp":1675297289000},"page":"619-628","source":"Crossref","is-referenced-by-count":3,"title":["<i>Sohlh1<\/i>loss of function male and female infertility model impacts overall health beyond gonadal dysfunction in mice"],"prefix":"10.1093","volume":"108","author":[{"given":"Marta","family":"Rodr\u00edguez-Escrib\u00e0","sequence":"first","affiliation":[{"name":"University of California San Francisco Department of Pathology, , San Francisco, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Rodr\u00edguez-Alonso","sequence":"additional","affiliation":[{"name":"University of California San Francisco Department of Pathology, , San Francisco, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Belur","sequence":"additional","affiliation":[{"name":"University of California San Francisco Department of Pathology, , San Francisco, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Rajkovic","sequence":"additional","affiliation":[{"name":"University of California San Francisco Department of Pathology, , San Francisco, CA , USA"},{"name":"University of California San Francisco Institute of Human Genetics, , San Francisco, CA , USA"},{"name":"University of California San Francisco Department of Obstetrics, Gynecology and Reproductive Sciences, , San Francisco, CA 94143 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"2023041705312122800_","first-page":"604","article-title":"Incidence of premature ovarian failure","volume":"67","author":"Coulam","year":"1986","journal-title":"Obstet Gynecol"},{"key":"2023041705312122800_","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/humrep\/dew027","article-title":"ESHRE guideline: management of women with premature ovarian insufficiency","volume":"31","author":"Webber","year":"2016","journal-title":"Hum Reprod"},{"key":"2023041705312122800_","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.676546","article-title":"Shared genetics between age at menopause, early menopause, POI and other traits","volume":"12","author":"Louwers","year":"2021","journal-title":"Front Genet"},{"key":"2023041705312122800_","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-0037-1603571","article-title":"Ovary as a biomarker of health and longevity: insights from genetics","volume":"35","author":"Rajkovic","year":"2017","journal-title":"Semin Reprod Med"},{"key":"2023041705312122800_","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1055\/s-0037-1599086","article-title":"Genetics of reproductive aging from gonadal dysgenesis through menopause","volume":"35","author":"Desai","year":"2017","journal-title":"Semin Reprod Med"},{"key":"2023041705312122800_","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev-genet-022020-023434","article-title":"Canary in the coal mine? 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