{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:17:58Z","timestamp":1769505478942,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2022YFC2702502"],"award-info":[{"award-number":["2022YFC2702502"]}]},{"name":"National Key Research and Development Project of China","award":["2021YFC2700303"],"award-info":[{"award-number":["2021YFC2700303"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101714"],"award-info":[{"award-number":["82101714"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925013"],"award-info":[{"award-number":["81925013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82288102"],"award-info":[{"award-number":["82288102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To investigate the expression profiles of circular RNAs (circRNAs) in the endometria of women with polycystic ovary syndrome (PCOS) and to explore the role of aberrant circ_0115118 expression in endometrial dysfunction in patients with PCOS. CircRNA microarray hybridization and bioinformatic analyses were performed to determine the expression patterns of circRNAs in the endometria of patients with or without PCOS, the expression of target circRNA was evaluated by real-time polymerase chain reaction (PCR). Cell counting kit-8 and Transwell assays were used to detect cellular proliferative, invasive, and migratory capacities. The influence of the circRNA on decidualization was explored by real-time PCR. Animal models were established to investigate the regulatory effect of the circRNA on embryo implantation. Downstream microRNAs and genes were predicted using bioinformatic websites and verified by dual-luciferase reporter assays, real-time PCR, and western blotting. In the endometria of patients with PCOS, there were 113 differentially expressed circRNAs in the secretory phase and 1119 differentially expressed circRNAs in the proliferative phase. The expression of circ_0115118 was significantly higher in endometrial stromal cells during the proliferative phase in patients with PCOS, leading to inhibition of cellular mobilization and embryo implantation. In addition, circ_0115118 exerted effects by sponging miR-138-1-3p, subsequently increasing the expression of WD repeat and FYVE domain-containing protein 2 (WDFY2). Circ_0115118 expression is dysregulated in the endometria of patients with PCOS and adversely affects endometrial function. Our findings reveal that circ_0115118 may be a potential therapeutic target to improve pregnancy outcomes in women with PCOS.<\/jats:p>","DOI":"10.1093\/biolre\/ioad017","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T16:22:27Z","timestamp":1676305347000},"page":"744-757","source":"Crossref","is-referenced-by-count":5,"title":["Circ_0115118 regulates endometrial functions through the miR-138-1-3p\/<i>WDFY2<\/i> axis in patients with PCOS"],"prefix":"10.1093","volume":"108","author":[{"given":"Zi","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenting","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Bai","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhong","family":"Ye","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Yin","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianliu","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Shan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"Peking University Third Hospital , Department of Obstetrics and Gynecology, , Beijing , China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing , China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing , China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"2023051502241338100_ref1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"2023051502241338100_ref2","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1093\/humrep\/det262","article-title":"Prevalence of polycystic ovary syndrome in women in China: a large community-based study","volume":"28","author":"Li","year":"2013","journal-title":"Hum Reprod"},{"key":"2023051502241338100_ref3","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/humupd\/dmy022","article-title":"Understanding variation in prevalence estimates of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"24","author":"Skiba","year":"2018","journal-title":"Hum Reprod Update"},{"key":"2023051502241338100_ref4","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/humupd\/dmaa029","article-title":"Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis","volume":"26","author":"Wekker","year":"2020","journal-title":"Hum Reprod Update"},{"key":"2023051502241338100_ref5","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.fertnstert.2018.08.021","article-title":"Beyond fertility: polycystic ovary syndrome and long-term health","volume":"110","author":"Cooney","year":"2018","journal-title":"Fertil Steril"},{"key":"2023051502241338100_ref6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2337\/db20-0800","article-title":"Polycystic ovary syndrome and risk of type 2 diabetes, coronary heart disease, and stroke","volume":"70","author":"Zhu","year":"2021","journal-title":"Diabetes"},{"key":"2023051502241338100_ref7","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/humupd\/dmaa051","article-title":"Endometrial function in women with polycystic ovary syndrome: a comprehensive review","volume":"27","author":"Palomba","year":"2021","journal-title":"Hum Reprod Update"},{"key":"2023051502241338100_ref8","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1073\/pnas.73.11.3852","article-title":"Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures","volume":"73","author":"Sanger","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023051502241338100_ref9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbagrm.2015.07.007","article-title":"Circular RNAs: identification, biogenesis and function","volume":"1859","author":"Ebbesen","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"2023051502241338100_ref10","article-title":"MicroRNA therapeutics in cancer: current advances and challenges","volume":"13","author":"Reda","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2023051502241338100_ref11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13578-021-00630-4","article-title":"MicroRNAs: emerging driver of cancer perineural invasion","volume":"11","author":"Zhang","year":"2021","journal-title":"Cell Biosci"},{"key":"2023051502241338100_ref12","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13133154","article-title":"New molecular mechanisms and clinical impact of circRNAs in human cancer","volume":"13","author":"Fontemaggi","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2023051502241338100_ref13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med"},{"key":"2023051502241338100_ref14","doi-asserted-by":"crossref","first-page":"15537","DOI":"10.1002\/jcp.28201","article-title":"High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients","volume":"234","author":"Wang","year":"2019","journal-title":"J Cell Physiol"},{"key":"2023051502241338100_ref15","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.fertnstert.2019.02.023","article-title":"Characterization of circular RNA expression profiles in cumulus cells from patients with polycystic ovary syndrome","volume":"111","author":"Che","year":"2019","journal-title":"Fertil Steril"},{"key":"2023051502241338100_ref16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12958-021-00839-5","article-title":"Circ_0043532 regulates miR-182\/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome","volume":"19","author":"Xu","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"2023051502241338100_ref17","doi-asserted-by":"crossref","first-page":"15414","DOI":"10.18632\/aging.103602","article-title":"Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome","volume":"12","author":"Huang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"2023051502241338100_ref18","doi-asserted-by":"crossref","first-page":"11001","DOI":"10.1111\/jcmm.15747","article-title":"CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression","volume":"24","author":"Liu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2023051502241338100_ref19","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1111\/jcmm.16231","article-title":"CircASPH promotes KGN cells proliferation through miR-375\/MAP2K6 axis in polycystic ovary syndrome","volume":"26","author":"Wu","year":"2022","journal-title":"J Cell Mol Med"},{"key":"2023051502241338100_ref20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bpobgyn.2016.03.008","article-title":"Polycystic ovary syndrome: endometrial markers","volume":"37","author":"Piltonen","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2023051502241338100_ref21","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1073\/pnas.0308058101","article-title":"Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder","volume":"101","author":"Sullivan","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023051502241338100_ref22","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1523\/JNEUROSCI.2304-17.2018","article-title":"Prepubertal development of GABAergic transmission to gonadotropin-releasing hormone (GnRH) neurons and postsynaptic response are altered by prenatal androgenization","volume":"38","author":"Berg","year":"2018","journal-title":"J Neurosci"},{"key":"2023051502241338100_ref23","doi-asserted-by":"crossref","first-page":"25302","DOI":"10.1038\/srep25302","article-title":"MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day","volume":"6","author":"Chen","year":"2016","journal-title":"Sci Rep"},{"key":"2023051502241338100_ref24","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1093\/nar\/gkab051","article-title":"SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining","volume":"49","author":"Akimova","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2023051502241338100_ref25","doi-asserted-by":"crossref","DOI":"10.3390\/v12040382","article-title":"SAMHD1 functions and human diseases","volume":"12","author":"Coggins","year":"2020","journal-title":"Viruses"},{"key":"2023051502241338100_ref26","doi-asserted-by":"crossref","first-page":"24627","DOI":"10.18632\/oncotarget.24821","article-title":"Androgen-induced alterations in endometrial proteins crucial in recurrent miscarriages","volume":"9","author":"Rahman","year":"2018","journal-title":"Oncotarget"},{"key":"2023051502241338100_ref27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21114092","article-title":"Endometrial Decidualization: the primary driver of pregnancy health","volume":"21","author":"Ng","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2023051502241338100_ref28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21061973","article-title":"Physiologic events of embryo implantation and Decidualization in human and non-human primates","volume":"21","author":"Ochoa-Bernal","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2023051502241338100_ref29","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/humrep\/dev117","article-title":"NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization","volume":"30","author":"Liao","year":"2015","journal-title":"Hum Reprod"},{"key":"2023051502241338100_ref30","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10815-016-0773-6","article-title":"What is the contribution of embryo-endometrial asynchrony to implantation failure?","volume":"33","author":"Teh","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"2023051502241338100_ref31","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00204-015-1551-4","article-title":"miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1","volume":"90","author":"Wang","year":"2016","journal-title":"Arch Toxicol"},{"key":"2023051502241338100_ref32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.21037\/atm-21-521","article-title":"MiR-138-1-3p alters the stemness and radiosensitivity of tumor cells by targeting CRIPTO and the JAK2\/STAT3 pathway in nasopharyngeal carcinoma","volume":"9","author":"Du","year":"2021","journal-title":"Ann Transl Med"},{"key":"2023051502241338100_ref33","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1515\/med-2021-0213","article-title":"circ_0038467 promotes PM2.5-induced bronchial epithelial cell dysfunction","volume":"16","author":"Jin","year":"2021","journal-title":"Open Med (Wars)"},{"key":"2023051502241338100_ref34","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1073\/pnas.0508832103","article-title":"The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis","volume":"103","author":"Hayakawa","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023051502241338100_ref35","doi-asserted-by":"crossref","first-page":"14101","DOI":"10.1074\/jbc.M110.110536","article-title":"Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2","volume":"285","author":"Walz","year":"2010","journal-title":"J Biol Chem"},{"key":"2023051502241338100_ref36","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2337\/db19-0699","article-title":"WDFY2 potentiates hepatic insulin sensitivity and controls endosomal localization of the insulin receptor and IRS1\/2","volume":"69","author":"Zhang","year":"2020","journal-title":"Diabetes"},{"key":"2023051502241338100_ref37","doi-asserted-by":"crossref","first-page":"101042831770482","DOI":"10.1177\/1010428317704821","article-title":"Overexpression of WDFY2 inhibits prostate cancer cell growth and migration via inactivation of Akt pathway","volume":"39","author":"Wang","year":"2017","journal-title":"Tumour Biol"},{"key":"2023051502241338100_ref38","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1038\/s41467-019-10794-w","article-title":"WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling","volume":"10","author":"Sneeggen","year":"2019","journal-title":"Nat Commun"},{"key":"2023051502241338100_ref39","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/humupd\/dmaa049","article-title":"Nanoparticles in pregnancy: the next frontier in reproductive therapeutics","volume":"27","author":"Pritchard","year":"2021","journal-title":"Hum Reprod Update"},{"key":"2023051502241338100_ref40","first-page":"20150129","article-title":"Cationic liposome-nucleic acid nanoparticle assemblies with applications in gene delivery and gene silencing","volume":"374","author":"Majzoub","year":"2016","journal-title":"Philos Trans A Math Phys Eng Sci"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioad017\/49402019\/ioad017.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/108\/5\/744\/50265684\/ioad017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/108\/5\/744\/50265684\/ioad017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:24:45Z","timestamp":1684117485000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/108\/5\/744\/7035422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,2,13]]},"published-print":{"date-parts":[[2023,5,10]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioad017","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,2,13]]}}}