{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:14:47Z","timestamp":1787008487984,"version":"build-2736575974"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Z01-ES102965"],"award-info":[{"award-number":["Z01-ES102965"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sertoli cells, first identified in the adult testis by Enrico Sertoli in the mid-nineteenth century, are known for their role in fostering male germ cell differentiation and production of mature sperm. It was not until the late twentieth century with the discovery of the testis-determining gene SRY that Sertoli cells\u2019 new function as the master regulator of testis formation and maleness was unveiled. Fetal Sertoli cells facilitate the establishment of seminiferous cords, induce appearance of androgen-producing Leydig cells, and cause regression of the female reproductive tracts. Originally thought be a terminally differentiated cell type, adult Sertoli cells, at least in the mouse, retain their plasticity and ability to transdifferentiate into the ovarian counterpart, granulosa cells. In this review, we capture the many phases of Sertoli cell differentiation from their fate specification in fetal life to fate maintenance in adulthood. We also introduce the discovery of a new phase of fetal Sertoli cell differentiation via autocrine\/paracrine factors with the freemartin characteristics. There remains much to learn about this intriguing cell type that lay the foundation for the maleness.<\/jats:p>","DOI":"10.1093\/biolre\/ioad037","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T13:34:26Z","timestamp":1679578466000},"page":"866-870","source":"Crossref","is-referenced-by-count":6,"title":["From Enrico Sertoli to freemartinism: the many phases of the master testis-determining cell"],"prefix":"10.1093","volume":"108","author":[{"given":"Humphrey Hung-Chang","family":"Yao","sequence":"first","affiliation":[{"name":"Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences , Research Triangle Park, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina F","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences , Research Triangle Park, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"2023061501033171700_ref1","first-page":"31","article-title":"E lesistenza di particulari cellule ramificate nei canalicoli seminiferi dell\u2019testicolo umno","volume":"7","author":"Sertoli","year":"1865","journal-title":"Morgagni"},{"key":"2023061501033171700_ref2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/scdb.1998.0203","article-title":"The central role of Sertoli cells in spermatogenesis","volume":"9","author":"Griswold","year":"1998","journal-title":"Semin Cell Dev Biol"},{"key":"2023061501033171700_ref3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature10239","article-title":"DMRT1 prevents female reprogramming in the postnatal mammalian 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