{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:48:07Z","timestamp":1790876887345,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Agriculture and Food Research Initiative Competitive","award":["2022-67015-36376"],"award-info":[{"award-number":["2022-67015-36376"]}]},{"DOI":"10.13039\/100005825","name":"USDA National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The placenta requires high levels of adenosine triphosphate to maintain a metabolically active state throughout gestation. The creatine\u2013creatine kinase\u2013phosphocreatine system is known to buffer adenosine triphosphate levels; however, the role(s) creatine\u2013creatine kinase\u2013phosphocreatine system plays in uterine and placental metabolism throughout gestation is poorly understood. In this study, Suffolk ewes were ovariohysterectomized on Days 30, 50, 70, 90, 110 and 125 of gestation (n\u2009=\u20093\u20135 ewes\/per day, except n\u2009=\u20092 on Day 50) and uterine and placental tissues subjected to analyses to measure metabolites, mRNAs, and proteins related to the creatine\u2013creatine kinase\u2013phosphocreatine system. Day of gestation affected concentrations and total amounts of guanidinoacetate and creatine in maternal plasma, amniotic fluid and allantoic fluid (P\u2009&amp;lt;\u20090.05). Expression of mRNAs for arginine:glycine amidinotransferase, guanidinoacetate methyltransferase, creatine kinase B, and solute carrier 16A12 in endometria and for arginine:glycine amidinotransferase and creatine kinase B in placentomes changed significantly across days of gestation (P\u2009&amp;lt;\u20090.05). The arginine:glycine amidinotransferase protein was more abundant in uterine luminal epithelium on Days 90 and 125 compared to Days 30 and 50 (P\u2009&amp;lt;\u20090.01). The chorionic epithelium of placentomes expressed guanidinoacetate methyltransferase and solute carrier 6A13 throughout gestation. Creatine transporter (solute carrier 6A8) was expressed by the uterine luminal epithelium and trophectoderm of placentomes throughout gestation. Creatine kinase (creatine kinase B and CKMT1) proteins were localized primarily to the uterine luminal epithelium and to the placental chorionic epithelium of placentomes throughout gestation. Collectively, these results demonstrate cell-specific and temporal regulation of components of the creatine\u2013creatine kinase\u2013phosphocreatine system that likely influence energy homeostasis for fetal\u2013placental development.<\/jats:p>","DOI":"10.1093\/biolre\/ioad052","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T15:10:56Z","timestamp":1683904256000},"page":"107-118","source":"Crossref","is-referenced-by-count":11,"title":["Creatine metabolism at the uterine\u2013placental interface throughout gestation in sheep"],"prefix":"10.1093","volume":"109","author":[{"given":"Nirvay","family":"Sah","sequence":"first","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Stenhouse","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M","family":"Halloran","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn M","family":"Moses","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heewon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Burghardt","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuller W","family":"Bazer","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"2024051205212237300_ref1","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.3390\/ijms20184530","article-title":"Immunohistochemical examination of trophoblast syncytialization during early placentation in sheep","volume":"20","author":"Seo","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024051205212237300_ref2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-540-78797-6_6","volume-title":"Synepitheliochorial Placentation\u00a0: Ruminants (Ewe and Cow). 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