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NLRP3 inflammasome and pyroptosis are present in endometriosis. Aberrant increase of Long noncoding (Lnc)-metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a vital role in endometriosis. However, the relationship between lnc-MALAT1, pyroptosis, and fibrosis is not completely known. In the present study, we found that the pyroptosis levels in ectopic endometrium of patients with endometriosis were significantly increased, consistent with fibrosis levels. Lipopolysaccharide (LPS)\u2009+\u2009ATP could induce pyroptosis of primary endometrial stromal cells (ESCs), thereby releasing interleukin (IL)-1\u03b2 and stimulating transforming growth factor (TGF)-\u03b21-mediated fibrosis. NLRP3 inhibitor MCC950 had the same effect as TGF-\u03b21 inhibitor SB-431542 in suppressing the fibrosis-inducing effect of LPS\u2009+\u2009ATP in vivo and in vitro. The abnormal increase of lnc-MALAT1 in ectopic endometrium was connected with NLRP3-mediated pyroptosis and fibrosis. Leveraging bioinformatic prediction and luciferase assays combined with western blotting and quantitative reverse transcriptase-polymerase chain reaction, we validated that lnc-MALAT1 sponges miR-141-3p to promote NLRP3 expression. Silencing lnc-MALAT1 in HESCs ameliorated NLRP3-mediated pyroptosis and IL-1\u03b2 release, thereby relieving TGF-\u03b21-mediated fibrosis. Consequently, our findings suggest that lnc-MALAT1 is critical for NLRP3-induced pyroptosis and fibrosis in endometriosis through sponging miR-141-3p, which may indicate a new therapeutic target of endometriosis treatment.<\/jats:p>","DOI":"10.1093\/biolre\/ioad057","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T15:20:03Z","timestamp":1685114403000},"page":"156-171","source":"Crossref","is-referenced-by-count":28,"title":["A novel mechanism regulating pyroptosis-induced fibrosis in endometriosis via lnc-MALAT1\/miR-141-3p\/NLRP3 pathway"],"prefix":"10.1093","volume":"109","author":[{"given":"Ying","family":"Xu","sequence":"first","affiliation":[{"name":"Huazhong University of Science and Technology Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, , Wuhan, China"},{"name":"Huazhong University of Science and Technology Department of Reproductive Medicine, Wuhan No.1 Hospital, Tongji Medical College, , Wuhan, 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Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Long","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jin","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Liang","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwen","family":"Weng","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Huazhong University of 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