{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:14:18Z","timestamp":1791836058837,"version":"4.3.4"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"name":"Ningbo 2025 Major Project of Science Technology and Innovation","award":["2021Z003"],"award-info":[{"award-number":["2021Z003"]}]},{"name":"Agricultural Independent Innovation Project of Jiangsu","award":["CX (22) 3081"],"award-info":[{"award-number":["CX (22) 3081"]}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772869"],"award-info":[{"award-number":["31772869"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872586"],"award-info":[{"award-number":["31872586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang","doi-asserted-by":"crossref","award":["LY18C190008"],"award-info":[{"award-number":["LY18C190008"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang","doi-asserted-by":"crossref","award":["LY18C1900013"],"award-info":[{"award-number":["LY18C1900013"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agriculture Key Special Project of Ningbo","award":["2015C110003"],"award-info":[{"award-number":["2015C110003"]}]},{"name":"Zhejiang Major Science Project","award":["2019C02059"],"award-info":[{"award-number":["2019C02059"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Insulin-like growth factor 1 (Igf1) is known to promote ovarian maturation by interacting with other hormones. However, the limited research on the role of Igf1 in the energy metabolism supply of gonads has hindered further exploration. To explore the role of Igf1 in gonadal development of silver pomfret, we analyzed the expression levels and the localization of igf1 mRNA and protein during testicular and ovarian development of silver pomfret. The results of the study showed upregulation of Igf1 in the critical period of vitellogenesis and sperm meiosis, which was found to be mainly expressed in the somatic cells of the gonads. Upon adding E2 and Igf1 to cultured gonadal tissues, the expression of energy-related genes was significantly increased, along with the E2-enhanced effect of Igf1 in the testis. Importantly, stimulation of both ovaries and testes with E2 and Igf1 led to a remarkable increase in the expression of vitellogenesis and meiosis-related genes. Therefore, we conclude that Igf1 promotes vitellogenesis and sperm meiosis by regulating gonadal energy production. Moreover, the expression of Igf1 in gonads is significantly regulated by E2. These findings provide new insights for the research of Igf1 in fish breeding, thus allowing the regulation of energy metabolism between growth and reproduction for successful reproductive outcomes.<\/jats:p>","DOI":"10.1093\/biolre\/ioad058","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T19:34:05Z","timestamp":1685043245000},"page":"227-237","source":"Crossref","is-referenced-by-count":8,"title":["Insulin-like growth factor 1 promotes the gonadal development of <i>Pampus argenteus<\/i> by regulating energy metabolism"],"prefix":"10.1093","volume":"109","author":[{"given":"Yaya","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfei","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture and Enhancement, Marine Fishery Institute of Zhejiang Province , Zhoushan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbing","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Zou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabao","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education , Ningbo , China"},{"name":"Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo , China"},{"name":"College of marine Sciences, Ningbo University , Ningbo , 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