{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:10:09Z","timestamp":1791774609344,"version":"4.3.4"},"reference-count":122,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YCJJ202201049"],"award-info":[{"award-number":["YCJJ202201049"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>During pregnancy, cell senescence at the maternal\u2013fetal interface is required for maternal well-being, placental development, and fetal growth. However, recent reports have shown that aberrant cell senescence is associated with multiple pregnancy-associated abnormalities, such as preeclampsia, fetal growth restrictions, recurrent pregnancy loss, and preterm birth. Therefore, the role and impact of cell senescence during pregnancy requires further comprehension. In this review, we discuss the principal role of cell senescence at the maternal\u2013fetal interface, emphasizing its \u201cbright side\u201d during decidualization, placentation, and parturition. In addition, we highlight the impact of its deregulation and how this \u201cdark side\u201d promotes pregnancy-associated abnormalities. Furthermore, we discuss novel and less invasive therapeutic practices associated with the modulation of cell senescence during pregnancy.<\/jats:p>","DOI":"10.1093\/biolre\/ioad071","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T03:12:21Z","timestamp":1688526741000},"page":"244-255","source":"Crossref","is-referenced-by-count":14,"title":["Flip a coin: cell senescence at the maternal\u2013fetal interface"],"prefix":"10.1093","volume":"109","author":[{"given":"Guang-Shun","family":"Gong","sequence":"first","affiliation":[{"name":"Huazhong University of Science and Technology Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, , Wuhan 430030, P.R . China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahindo P","family":"Muyayalo","sequence":"additional","affiliation":[{"name":"University of Kinshasa Department of Obstetrics and Gynecology, , Kinshasa, D.R . Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, , Wuhan 430030, P.R . China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Xiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, , Wuhan 430030, P.R . China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Hua","family":"Liao","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, , Wuhan 430030, P.R . China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"2023091508550850500_ref1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI200422991","article-title":"Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface","volume":"114","author":"Red-Horse","year":"2004","journal-title":"J Clin Invest"},{"key":"2023091508550850500_ref2","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1126\/science.1071601","article-title":"Deciphering the cross-talk of implantation: advances and challenges","volume":"296","author":"Paria","year":"2002","journal-title":"Science"},{"key":"2023091508550850500_ref3","doi-asserted-by":"crossref","first-page":"S6.e1","DOI":"10.1016\/j.ajog.2015.07.050","article-title":"What is the placenta?","volume":"213","author":"Burton","year":"2015","journal-title":"Am J Obstet 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