{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:26:41Z","timestamp":1782790001599,"version":"3.54.5"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD084316"],"award-info":[{"award-number":["R01HD084316"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PS00241264"],"award-info":[{"award-number":["PS00241264"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endometrial inflammation is associated with reduced pregnancy per artificial insemination (AI) and increased pregnancy loss in cows. It was hypothesized that induced endometritis alters histotroph composition and induces inflammatory signatures on conceptus that compromise development. In Experiment 1, lactating cows were assigned to control (CON; n\u2009=\u200923) or to an intrauterine infusion of Escherichia coli and Trueperella pyogenes (ENDO; n\u2009=\u200934) to induce endometritis. Cows received AI 26\u00a0days after treatment, and the uterine fluid and conceptuses were collected on day 16 after AI. In Experiment 2, Holstein heifers were assigned to CON (n\u2009=\u200914) or ENDO (n\u2009=\u200914). An embryo was transferred on day 7 of the estrous cycle, and uterine fluid and conceptuses were recovered on day 16. Composition of histotroph and trophoblast and embryonic disc gene expression were assessed. Bacterial-induced endometritis in lactating cows altered histotroph composition and pathways linked to phospholipid synthesis, cellular energy production, and the Warburg effect. Also, ENDO reduced conceptus length in cows and altered expression of genes involved in pathogen recognition, nutrient uptake, cell growth, choline metabolism, and conceptus signaling needed for maternal recognition of pregnancy. The impact of ENDO was lesser on conceptuses from heifers receiving embryo transfer; however, the affected genes and associated pathways involved restricted growth and increased immune response similar to the observed responses to ENDO in conceptuses from lactating cows. Bacterial-induced endometrial inflammation altered histotroph composition, reduced conceptus growth, and caused embryonic cells to activate survival rather than anabolic pathways that could compromise development.<\/jats:p>","DOI":"10.1093\/biolre\/ioad088","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T20:57:07Z","timestamp":1691096227000},"page":"415-431","source":"Crossref","is-referenced-by-count":13,"title":["Induced endometrial inflammation compromises conceptus development in dairy cattle"],"prefix":"10.1093","volume":"109","author":[{"given":"Ali","family":"Husnain","sequence":"first","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roney","family":"Zimpel","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie J","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milerky C","family":"Perdomo","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana N","family":"Marinho","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Ashrafi","sequence":"additional","affiliation":[{"name":"Metabolomics Department, Beaumont Health , Royal Oak, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart F","family":"Graham","sequence":"additional","affiliation":[{"name":"Metabolomics Department, Beaumont Health , Royal Oak, MI , USA"},{"name":"Oakland University-William Beaumont School of Medicine , Rochester, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette V","family":"Bishop","sequence":"additional","affiliation":[{"name":"Animal Reproduction and Biotechnology Laboratory , Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, , Fort Collins, CO , USA"},{"name":"Colorado State University , Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, , Fort Collins, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Hansen","sequence":"additional","affiliation":[{"name":"Animal Reproduction and Biotechnology Laboratory , Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, , Fort Collins, CO , USA"},{"name":"Colorado State University , Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, , Fort Collins, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang C","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M","family":"Gonella-Diaza","sequence":"additional","affiliation":[{"name":"North Florida Research and Education Center, University of Florida , Marianna, FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo C","family":"Chebel","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences , College of Veterinary Medicine, , Gainesville, FL , USA"},{"name":"University of Florida , College of Veterinary Medicine, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Martin","family":"Sheldon","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Swansea University , Swansea , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Bromfield","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 E P","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"},{"name":"University of Florida , DH Barron Reproductive and Perinatal Biology Research Program, , Gainesville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"2023101605091287900_ref1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1530\/jrf.0.0650141","article-title":"Purification and properties of a major, low molecular weight protein released by the trophoblast of sheep blastocysts at day 13\u201321","volume":"65","author":"Godkin","year":"1982","journal-title":"J Reprod Fert"},{"key":"2023101605091287900_ref2","first-page":"1144","article-title":"Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium","volume":"137","author":"Spencer","year":"1996","journal-title":"Rapid Commun"},{"key":"2023101605091287900_ref3","doi-asserted-by":"crossref","first-page":"d1879","DOI":"10.2741\/spencer","article-title":"Biology of progesterone action during pregnancy recognition and maintenance of pregnancy","volume":"7","author":"Spencer","year":"2002","journal-title":"Front Biosci"},{"key":"2023101605091287900_ref4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1095\/biolreprod.115.134908","article-title":"Biology of preimplantation conceptus at the onset of elongation in dairy cows","volume":"94","author":"Ribeiro","year":"2016","journal-title":"Biol Reprod"},{"key":"2023101605091287900_ref5","first-page":"672","article-title":"Biochemical characterization of progesterone-induced alterations in bovine uterine fluid amino acid and carbohydrate composition during the conceptus elongation window","volume":"100","author":"Simintiras","year":"2019","journal-title":"Biol Reprod"},{"key":"2023101605091287900_ref6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/biolre\/ioz101","article-title":"The biochemistry surrounding the bovine conceptus elongation","volume":"101","author":"Simintiras","year":"2019","journal-title":"Biol Reprod"},{"key":"2023101605091287900_ref7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1071\/RD16359","article-title":"Insights into conceptus elongation and establishment of pregnancy in ruminants","volume":"29","author":"Spencer","year":"2017","journal-title":"Reprod Fert Devel"},{"key":"2023101605091287900_ref8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/biolre\/ioaa069","article-title":"Experimentally induced endometritis impairs the developmental capacity of bovine oocytes","volume":"103","author":"Dickson","year":"2020","journal-title":"Biol Reprod"},{"key":"2023101605091287900_ref9","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.3168\/jds.2015-10337","article-title":"Carryover effect of postpartum inflammatory diseases on developmental biology and fertility in lactating dairy cows","volume":"99","author":"Ribeiro","year":"2016","journal-title":"J Dairy Sci"},{"key":"2023101605091287900_ref10","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3168\/jds.S0022-0302(02)74302-6","article-title":"Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows","volume":"85","author":"LeBlanc","year":"2002","journal-title":"J Dairy Sci"},{"key":"2023101605091287900_ref11","doi-asserted-by":"crossref","first-page":"11970","DOI":"10.3168\/jds.2020-19070","article-title":"Inflammatory diseases in dairy cows: risk factors and associations with pregnancy after embryo transfer","volume":"103","author":"Edelhoff","year":"2020","journal-title":"J Dairy Sci"},{"key":"2023101605091287900_ref12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1530\/REP-19-0564","article-title":"Uterine infection alters the transcriptome of the bovine reproductive tract three months later","volume":"160","author":"Horlock","year":"2020","journal-title":"Reproduction"},{"key":"2023101605091287900_ref13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.vetmic.2011.11.034","article-title":"Association between virulence factors of Escherichia coli, Fusobacterium necrophorum, and Arcanobacterium pyogenes and uterine diseases of dairy cows","volume":"157","author":"Bicalho","year":"2012","journal-title":"Vet Microbiol"},{"key":"2023101605091287900_ref14","doi-asserted-by":"crossref","first-page":"11786","DOI":"10.3168\/jds.2019-17106","article-title":"Symposium review: the uterine microbiome associated with the development of uterine disease in dairy cows","volume":"102","author":"Galv\u00e3o","year":"2019","journal-title":"J Dairy Sci"},{"key":"2023101605091287900_ref15","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.2527\/jas.2014-8496","article-title":"Physiology and endocrinology symposium: uterine infection: linking infection and innate immunity with infertility in the high-producing dairy cow","volume":"93","author":"Bromfield","year":"2015","journal-title":"J Anim Sci"},{"key":"2023101605091287900_ref16","first-page":"e00217","article-title":"Draft genome sequence of Escherichia coli MS499, isolated from the infected uterus of a postpartum cow with metritis","volume":"2","author":"Goldstone","year":"2014","journal-title":"Genome Announc"},{"key":"2023101605091287900_ref17","first-page":"e00217","article-title":"Draft genome sequence of Trueperella pyogenes, isolated from the infected uterus of a postpartum cow with metritis","volume":"2","author":"Goldstone","year":"2014","journal-title":"Genome Announc"},{"key":"2023101605091287900_ref18","doi-asserted-by":"crossref","first-page":"38828","DOI":"10.1038\/srep38828","article-title":"General calibration of microbial growth in microplate readers","volume":"6","author":"Stevenson","year":"2016","journal-title":"Sci Rep"},{"key":"2023101605091287900_ref19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.theriogenology.2003.03.001","article-title":"Endometrial cytology and ultrasonography for the detection of subclinical endometritis in postpartum dairy cows","volume":"62","author":"Kasimanickam","year":"2004","journal-title":"Theriogenology"},{"key":"2023101605091287900_ref20","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.3168\/jds.2018-15595","article-title":"A model of clinical endometritis in Holstein heifers using pathogenic Escherichia coli and Trueperella pyogenes","volume":"102","author":"Piersanti","year":"2019","journal-title":"J Dairy Sci"},{"key":"2023101605091287900_ref21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1292\/jvms1939.44.15","article-title":"Quantitative determination of bovine serum haptoglobin and its elevation in some inflammatory diseases","volume":"44","author":"Makimura","year":"1982","journal-title":"Jpn J Vet Sci"},{"key":"2023101605091287900_ref22","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/biolre\/ioab149","article-title":"Peri-estrus ovarian, uterine, and hormonal variables determine the uterine luminal fluid metabolome in beef heifers","volume":"105","author":"Silva","year":"2021","journal-title":"Biol Reprod"},{"key":"2023101605091287900_ref23","doi-asserted-by":"crossref","first-page":"9051","DOI":"10.3168\/jds.2016-11348","article-title":"Prevalence of cytological endometritis and effect on pregnancy outcomes at the time of insemination in nulliparous dairy heifers","volume":"99","author":"Pascottini","year":"2016","journal-title":"J Dairy Sci"},{"key":"2023101605091287900_ref24","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.3168\/jds.2013-7093","article-title":"Hormonal manipulation in the 5-day timed artificial insemination protocol to optimize estrous cycle synchrony and fertility in dairy heifers","volume":"96","author":"Lima","year":"2013","journal-title":"J Dairy Sci"},{"key":"2023101605091287900_ref25","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ygeno.2009.04.008","article-title":"A powerful and flexible linear mixed model framework for the analysis of relative quantification RT-PCR data","volume":"94","author":"Steibel","year":"2009","journal-title":"Genomics"},{"key":"2023101605091287900_ref26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2105-7-85","article-title":"Statistical analysis of real-time PCR data","volume":"7","author":"Yuan","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"2023101605091287900_ref27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u2206\u2206CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2023101605091287900_ref28","doi-asserted-by":"crossref","first-page":"W147","DOI":"10.1093\/nar\/gkw419","article-title":"Heatmapper: web-enabled heat mapping for all","volume":"44","author":"Babicki","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2023101605091287900_ref29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations","volume":"26","author":"Box","year":"1964","journal-title":"J R Stat Soc B"},{"key":"2023101605091287900_ref30","doi-asserted-by":"crossref","first-page":"865","DOI":"10.2134\/agronj2008.0226x","article-title":"Data transformation in statistical analysis of field trials with changing treatment variance","volume":"101","author":"Piepho","year":"2009","journal-title":"Agron J"},{"key":"2023101605091287900_ref31","volume-title":"How to Obtain Those Nasty Standard Errors from Transformed Data\u2014and Why They Should Not Be Used. Page 20 in Biometry Research Unit\u2014Internal Report 7","author":"J\u00f8rgensen","year":"1998"},{"key":"2023101605091287900_ref32","doi-asserted-by":"crossref","first-page":"W652","DOI":"10.1093\/nar\/gkp356","article-title":"MetaboAnalyst: a web server for metabolomic data analysis and interpretation","volume":"37","author":"Xia","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2023101605091287900_ref33","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0\u2014making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023101605091287900_ref34","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41596-022-00710-w","article-title":"Using MetaboAnalyst 5.0 for LC\u2013HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data","volume":"17","author":"Pang","year":"2022","journal-title":"Nat Protoc"},{"key":"2023101605091287900_ref35","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkp1002","article-title":"SMPDB: the small molecule pathway database","volume":"38","author":"Frolkis","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"2023101605091287900_ref36","doi-asserted-by":"crossref","first-page":"D478","DOI":"10.1093\/nar\/gkt1067","article-title":"SMPDB 2.0: big improvements to the small molecule pathway database","volume":"42","author":"Jewison","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2023101605091287900_ref37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2023101605091287900_ref38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/rep.0.1240289","article-title":"Evidence that absence of endometrial gland secretions in uterine gland knockout ewes\u2019 compromises conceptus survival and elongation","volume":"124","author":"Gray","year":"2002","journal-title":"Reproduction"},{"key":"2023101605091287900_ref39","first-page":"91","article-title":"Antiluteolytic effects of bovine trophoblast protein 1","volume":"37","author":"Thatcher","year":"1989","journal-title":"J Reprod Fertil Suppl"},{"key":"2023101605091287900_ref40","doi-asserted-by":"crossref","first-page":"e0265062","DOI":"10.1371\/journal.pone.0265062","article-title":"The endometrial transcriptomic response to pregnancy is altered in cows after uterine infection","volume":"17","author":"Dickson","year":"2022","journal-title":"PloS One"},{"key":"2023101605091287900_ref41","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1071\/RD11915","article-title":"The effects of endometritis on the establishment of pregnancy in cattle","volume":"24","author":"Gilbert","year":"2012","journal-title":"Reprod Fert Develop"},{"key":"2023101605091287900_ref42","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.3390\/ijms18112447","article-title":"CDX2 stimulates the proliferation of porcine intestinal epithelial cells by activating the mTORC1 and Wnt\/\u03b2-catenin signaling pathways","volume":"18","author":"Fan","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2023101605091287900_ref43","doi-asserted-by":"crossref","first-page":"F21","DOI":"10.1530\/REP-17-0330","article-title":"Transcriptional control of IFNT expression","volume":"154","author":"Ezashi","year":"2017","journal-title":"Reproduction"},{"key":"2023101605091287900_ref44","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"2023101605091287900_ref45","doi-asserted-by":"crossref","first-page":"14484","DOI":"10.1074\/jbc.273.23.14484","article-title":"Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism","volume":"273","author":"Hara","year":"1998","journal-title":"J Biol Chem"},{"key":"2023101605091287900_ref46","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2017.09.046","article-title":"mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient","volume":"171","author":"Wyant","year":"2017","journal-title":"Cell"},{"key":"2023101605091287900_ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine metabolism: nitric oxide and beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem J"},{"key":"2023101605091287900_ref48","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1096\/fj.13-248757","article-title":"Functional role of arginine during the peri-implantation period of pregnancy. I. Consequences of loss of function of arginine transporter SLC7A1 mRNA in ovine conceptus trophectoderm","volume":"28","author":"Wang","year":"2014","journal-title":"FASEB J"},{"key":"2023101605091287900_ref49","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat Immunol"},{"key":"2023101605091287900_ref50","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1128\/IAI.74.2.940-946.2006","article-title":"Activation of toll-like receptor 9 by DNA from different bacterial species","volume":"74","author":"Dalpke","year":"2006","journal-title":"Infect Immun"},{"key":"2023101605091287900_ref51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"2023101605091287900_ref52","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1530\/jrf.0.1060299","article-title":"Oxygen uptake and carbohydrate metabolism by in vitro derived bovine embryos","volume":"106","author":"Thompson","year":"1996","journal-title":"J Reprod Fert"},{"key":"2023101605091287900_ref53","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1042\/BST20120352","article-title":"Parallels between embryo and cancer cell metabolism","volume":"41","author":"Smith","year":"2013","journal-title":"Biochem Soc Trans"},{"key":"2023101605091287900_ref54","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","article-title":"Phosphatidylcholine and choline homeostasis","volume":"49","author":"Li","year":"2008","journal-title":"J Lipid Res"},{"key":"2023101605091287900_ref55","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2023101605091287900_ref56","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1642-431X(12)60012-6","article-title":"Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways","volume":"8","author":"Bazer","year":"2008","journal-title":"Reprod Biol"},{"key":"2023101605091287900_ref57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/biolre\/ioy047","article-title":"Mechanisms for the establishment and maintenance of pregnancy: synergies from scientific collaborations","volume":"99","author":"Bazer","year":"2018","journal-title":"Biol Reprod"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioad088\/51172839\/ioad088.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/109\/4\/415\/52086223\/ioad088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/109\/4\/415\/52086223\/ioad088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T17:26:09Z","timestamp":1729877169000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/109\/4\/415\/7237300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,8,4]]},"published-print":{"date-parts":[[2023,10,13]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioad088","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10]]},"published":{"date-parts":[[2023,8,4]]}}}