{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:50:32Z","timestamp":1773784232617,"version":"3.50.1"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011253","name":"American Petroleum Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011253","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PHASE Department of INRAE"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gene knockout experiments have shown that many genes are dispensable for a given biological function. In this review, we make an assessment of male and female germ cell-specific genes dispensable for the function of reproduction in mice, the inactivation of which does not affect fertility. In particular, we describe the deletion of a 1\u00a0Mb block containing nineteen paralogous genes of the oogenesin\/Pramel family specifically expressed in female and\/or male germ cells, which has no consequences in both sexes. We discuss this notion of dispensability and the experiments that need to be carried out to definitively conclude that a gene is dispensable for a function.<\/jats:p>","DOI":"10.1093\/biolre\/ioad092","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T15:23:08Z","timestamp":1691680988000},"page":"408-414","source":"Crossref","is-referenced-by-count":1,"title":["The paralogs\u2019 enigma of germ-cell specific genes dispensable for fertility: the case of 19 oogenesin genes"],"prefix":"10.1093","volume":"109","author":[{"given":"Johan","family":"Castille","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, GABI , Jouy-en-Josas , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Th\u00e9pot","sequence":"additional","affiliation":[{"name":"INRAE , UMR 1198 BREED, Jouy-en-Josas , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Fouch\u00e9court","sequence":"additional","affiliation":[{"name":"PRC INRAE , CNRS, IFCE, Universit\u00e9 de Tours, Nouzilly , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozenn","family":"Dalbies-Tran","sequence":"additional","affiliation":[{"name":"PRC INRAE , CNRS, IFCE, Universit\u00e9 de Tours, Nouzilly , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Passet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, GABI , Jouy-en-Josas , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Daniel-Carlier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, GABI , Jouy-en-Josas , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Vilotte","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, GABI , Jouy-en-Josas , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Monget","sequence":"additional","affiliation":[{"name":"PRC INRAE , CNRS, IFCE, Universit\u00e9 de Tours, Nouzilly , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"2023101605100244500_ref1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.copbio.2011.04.017","article-title":"Gene dispensability","volume":"22","author":"Korona","year":"2011","journal-title":"Curr Opin Biotechnol"},{"key":"2023101605100244500_ref2","doi-asserted-by":"crossref","first-page":"0008","DOI":"10.1038\/msb4100050","article-title":"Construction of Escherichia coli K-12 in-frame, 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