{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:51:15Z","timestamp":1790218275501,"version":"4.1.0"},"reference-count":121,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771662"],"award-info":[{"award-number":["31771662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2019JDRC0022"],"award-info":[{"award-number":["2019JDRC0022"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infertility is a challenging health problem that affects 8\u201315% of couples worldwide. Establishing pregnancy requires successful embryo implantation, but about 85% of unsuccessful pregnancies are due to embryo implantation failure or loss soon after. Factors crucial for successful implantation include invasive blastocysts, receptive endometrium, invasion of trophoblast cells, and regulation of immune tolerance at the maternal\u2013fetal interface. Maternal\u2013fetal crosstalk, which relies heavily on protein\u2013protein interactions, is a critical factor in implantation that involves multiple cellular communication and molecular pathways. Glycosylation, a protein modification process, is closely related to cell growth, adhesion, transport, signal transduction, and recognition. Protein glycosylation plays a crucial role in maternal\u2013fetal crosstalk and can be divided into N-glycosylation and O-glycosylation, which are often terminated by sialylation or fucosylation. This review article examines the role of protein glycosylation in maternal\u2013fetal crosstalk based on two transcriptome datasets from the GEO database (GSE139087 and GSE113790) and existing research, particularly in the context of the mechanism of protein glycosylation and embryo implantation. Dysregulation of protein glycosylation can lead to adverse pregnancy outcomes, such as missed abortion and recurrent spontaneous abortion, underscoring the importance of a thorough understanding of protein glycosylation in the diagnosis and treatment of female reproductive disorders. This knowledge could have significant clinical implications, leading to the development of more effective diagnostic and therapeutic approaches for these conditions.<\/jats:p>","DOI":"10.1093\/biolre\/ioad105","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T11:17:32Z","timestamp":1693653452000},"page":"785-798","source":"Crossref","is-referenced-by-count":18,"title":["Protein glycosylation: bridging maternal\u2013fetal crosstalk during embryo implantation"],"prefix":"10.1093","volume":"109","author":[{"given":"Xinrui","family":"Sun","sequence":"first","affiliation":[{"name":"Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University , Chengdu, Sichuan , P.R. China"},{"name":"Department of Obstetrics and Gynecology , West China Second Hospital, , Chengdu, Sichuan , China"},{"name":"Sichuan University , West China Second Hospital, , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Feng","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics\/Gynecology , Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, , Chengdu, Sichuan , China"},{"name":"West China Second University Hospital, Sichuan University , Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , West China Second Hospital, , Chengdu, Sichuan , China"},{"name":"Sichuan University , West China Second Hospital, , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University , Chengdu, Sichuan , P.R. China"},{"name":"Department of Obstetrics and Gynecology , West China Second Hospital, , Chengdu, Sichuan , China"},{"name":"Sichuan University , West China Second Hospital, , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"2024010817191301800_ref1","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface","volume":"10","author":"Yang","year":"2019","journal-title":"Front Immunol"},{"key":"2024010817191301800_ref2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11684-010-0101-y","article-title":"Pathogenesis, diagnosis, and treatment of recurrent spontaneous abortion with immune type","volume":"4","author":"Lin","year":"2010","journal-title":"Front Med 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