{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:48:52Z","timestamp":1790102932616,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Agriculture and Food Research Initiative","award":["2018-67015-27595"],"award-info":[{"award-number":["2018-67015-27595"]}]},{"name":"Agriculture and Food Research Initiative","award":["2013-67015-20960"],"award-info":[{"award-number":["2013-67015-20960"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Perinatal nutrition modulates the hypothalamic neurocircuitries controlling GnRH release, thus programming pubertal maturation in female mammals. Objectives of experiments reported here were to test the hypotheses that prenatal nutrition during mid- to late gestation interacts with postnatal nutrition during the juvenile period in heifer offspring to alter expression of leptin receptor (LepR) variants (ObRa, ObRb, ObRc, ObRt), and lipoprotein transporter molecules (LRP1 and 2) in the choroid plexus, leptin transport across the blood\u2013brain barrier, and hypothalamic\u2013hypophyseal responsiveness to exogenous ovine leptin (oleptin) during fasting. Nutritional programming of heifers employed a 3 \u00d7 2 factorial design of maternal (high, H; low, L; and moderate, M) \u00d7 postnatal (H and L) dietary treatments. Results (Expt. 1) demonstrated that prepubertal heifers born to L dams, regardless of postnatal diet, had reduced expression of the short isoform of ObRc compared to H and M dams, with sporadic effects of undernutrition (L or LL) on ObRb, ObRt, and LRP1. Intravenous administration of oleptin to a selected postpubertal group (HH, MH, LL) of ovariectomized, estradiol-implanted heifers fasted for 56\u00a0h (Expt. 2) did not create detectable increases in third ventricle cerebrospinal fluid but increased gonadotropin secretion in all nutritional groups tested. Previous work has shown that leptin enhances gonadotropin secretion during fasting via effects at both hypothalamic and anterior pituitary levels in cattle. Given the apparent lack of robust transfer of leptin across the blood\u2013brain barrier in the current study, effects of leptin at the adenohypophyseal level may predominate in this experimental model.<\/jats:p>","DOI":"10.1093\/biolre\/ioad118","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T07:33:02Z","timestamp":1694503982000},"page":"892-903","source":"Crossref","is-referenced-by-count":6,"title":["Interaction of pre- and postnatal nutrition on expression of leptin receptor variants and transporter molecules, leptin transport, and functional response to leptin in heifers"],"prefix":"10.1093","volume":"109","author":[{"given":"Gary L","family":"Williams","sequence":"first","affiliation":[{"name":"Texas A&M AgriLife Research Animal Reproduction Laboratory, , Beeville, TX , USA"},{"name":"Texas A&M University Department of Animal Science, , College Station, TX , 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M","family":"West","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna R C","family":"Alves","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Garza","sequence":"additional","affiliation":[{"name":"Texas A&M AgriLife Research Animal Reproduction Laboratory, , Beeville, TX , USA"},{"name":"Texas A&M University Department of Animal Science, , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jr Thomas H","family":"Welsh","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo C","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"2024010817191041400_ref1","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J Am Coll Nutr"},{"key":"2024010817191041400_ref2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.siny.2004.03.001","article-title":"Maternal constraint of fetal growth and its consequences","volume":"9","author":"Gluckman","year":"2004","journal-title":"Semin Fetal Neonatal 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