{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:37:09Z","timestamp":1793450229296,"version":"4.5.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Government of Canada\u2019s New Frontiers in Research Fund"},{"name":"Canadian Foundation for Innovation","id":[{"id":"https:\/\/ror.org\/000az4664","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Newfoundland and Labrador Department of Industry, Energy and Technology","id":[{"id":"https:\/\/ror.org\/051rfg544","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Maternal exposure to microplastics and nanoplastics has been shown to result in fetal growth restriction in mice. In this study, we investigated the placental and fetal hemodynamic responses to plastics exposure in mice using high-frequency ultrasound. Healthy, pregnant CD-1 dams were given either 106\u00a0ng\/L of 5\u00a0\u03bcm polystyrene microplastics or 106\u00a0ng\/L of 50\u00a0nm polystyrene nanoplastics in drinking water throughout gestation and were compared with controls. Maternal exposure to both microplastics and nanoplastics resulted in evidence of placental dysfunction that was highly dependent on the particle size. The umbilical artery blood flow increased by 48% in the microplastic-exposed group and decreased by 25% in the nanoplastic-exposed group compared to controls (p\u2009&amp;lt;\u20090.05). The microplastic- and nanoplastic-exposed fetuses showed a significant decrease in the middle cerebral artery pulsatility index of 10% and 13%, respectively, compared to controls (p\u2009&amp;lt;\u20090.05), indicating vasodilation of the cerebral circulation, a fetal adaptation that is part of the brain sparing response to preserve oxygen delivery. Hemodynamic markers of placental dysfunction and fetal hypoxia were more pronounced in the group exposed to polystyrene nanoplastics, suggesting nanoplastic exposure during human pregnancy has the potential to disrupt fetal brain development, which in turn may cause suboptimal neurodevelopmental outcomes.<\/jats:p>","DOI":"10.1093\/biolre\/ioad126","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T16:57:53Z","timestamp":1694797073000},"page":"211-218","source":"Crossref","is-referenced-by-count":64,"title":["Polystyrene micro- and nanoplastics cause placental dysfunction in mice"],"prefix":"10.1093","volume":"110","author":[{"given":"Katherine C","family":"Dibbon","sequence":"first","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace V","family":"Mercer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre S","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Hanrahan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L","family":"Steeves","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C M","family":"Ringer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 J","family":"Simpson","sequence":"additional","affiliation":[{"name":"Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrna J","family":"Simpson","sequence":"additional","affiliation":[{"name":"Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet A","family":"Baschat","sequence":"additional","affiliation":[{"name":"Department of Gynecology & Obstetrics , Johns 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G","family":"Sled","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Toronto , Toronto, Ontario , Canada"},{"name":"Translational Medicine, Hospital for Sick Children , Toronto, Ontario, Canada"},{"name":"Department of Medical Biophysics, University of Toronto , Toronto, Ontario , Canada"},{"name":"Mouse Imaging Centre, Hospital for Sick Children , Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J","family":"Jobst","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay S","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland , St. John\u2019s, Newfoundland and Labrador , Canada"},{"name":"Discipline of Radiology, Memorial University of 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