{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:09:38Z","timestamp":1792012178480,"version":"4.4.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Funds for Outstanding Newcomers, Shanghai Sixth People\u2019s Hospital","award":["X-3664"],"award-info":[{"award-number":["X-3664"]}]},{"name":"Shanghai Jiao Tong University Trans-Med Awards Research","award":["20210201"],"award-info":[{"award-number":["20210201"]}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-level Local Universities in Shanghai","doi-asserted-by":"publisher","award":["SHSMU-ZLCX20210202"],"award-info":[{"award-number":["SHSMU-ZLCX20210202"]}],"id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971403"],"award-info":[{"award-number":["81971403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171669"],"award-info":[{"award-number":["82171669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Signal transducer and activator of transcription 3 (STAT3), when phosphorylated at tyrosine 705, plays an important role in endometrial stromal cell decidualization and the receptivity of the endometrial epithelium during embryo implantation. However, the function of phosphorylated STAT3 (p-STAT3) in normal uterine receptivity is distinct from that in adenomyosis and endometriosis. In normal pregnancy, STAT3 phosphorylation in the endometrial epithelium determines the success of embryo implantation by regulating uterine receptivity. Additionally, p-STAT3 promotes cellular proliferation and differentiation during endometrial decidualization, which is crucial for embryonic development. In contrast, excessive STAT3 phosphorylation occurs in adenomyosis and endometriosis, which may lead to disease progression. Therefore, achieving a delicate balance in STAT3 activation is crucial. This review aimed to focus on the current understanding and knowledge gaps regarding the control of p-STAT3 activity in normal and pathological endometrial processes. This topic is important because precise control of p-STAT3 production could alleviate the symptoms of adenomyosis and endometriosis, improve endometrial receptivity, and potentially mitigate infertility without compromising normal fertility processes.<\/jats:p>","DOI":"10.1093\/biolre\/ioad148","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T15:22:03Z","timestamp":1699284123000},"page":"5-13","source":"Crossref","is-referenced-by-count":15,"title":["Paradoxical role of phosphorylated STAT3 in normal fertility and the pathogenesis of adenomyosis and endometriosis"],"prefix":"10.1093","volume":"110","author":[{"given":"Yichi","family":"Xu","sequence":"first","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Reproductive Medicine Center, , Shanghai , China"},{"name":"Shanghai Jiao Tong University Shanghai Key Laboratory of Embryo Original Diseases, The International Peace Maternity and Child Health Hospital, School of Medicine, , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Reproductive Medicine Center, , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanmei","family":"Qin","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Reproductive Medicine Center, , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Reproductive Medicine Center, , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"2024011612162958800_ref1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12943-020-01258-7","article-title":"Targeting STAT3 in cancer immunotherapy","volume":"19","author":"Zou","year":"2020","journal-title":"Mol Cancer"},{"key":"2024011612162958800_ref2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"2024011612162958800_ref3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061591","article-title":"Structural biology of STAT3 and its implications for anticancer therapies development","volume":"19","author":"Sgrignani","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2024011612162958800_ref4","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"2024011612162958800_ref5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nsmb941","article-title":"Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor","volume":"12","author":"Skiniotis","year":"2005","journal-title":"Nat Struct Mol Biol"},{"key":"2024011612162958800_ref6","doi-asserted-by":"crossref","first-page":"106233","DOI":"10.1016\/j.ejps.2022.106233","article-title":"Combinational silencing of components involved in JAK\/STAT signaling pathway","volume":"175","author":"Bousoik","year":"2022","journal-title":"Eur J Pharm Sci"},{"key":"2024011612162958800_ref7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12964-018-0268-4","article-title":"Activation of the JAK\/STAT3 and PI3K\/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells","volume":"16","author":"Zegeye","year":"2018","journal-title":"Cell Commun Signal"},{"key":"2024011612162958800_ref8","doi-asserted-by":"crossref","first-page":"119222","DOI":"10.1016\/j.envpol.2022.119222","article-title":"BHPF exposure impairs mouse and human decidualization","volume":"304","author":"Jin","year":"2022","journal-title":"Environ Pollut"},{"key":"2024011612162958800_ref9","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1073\/pnas.131568898","article-title":"Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis","volume":"98","author":"Bowman","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024011612162958800_ref10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cyto.2008.05.007","article-title":"IL-6 receptor expression and IL-6 effects change during osteoblast differentiation","volume":"43","author":"Li","year":"2008","journal-title":"Cytokine"},{"key":"2024011612162958800_ref11","doi-asserted-by":"crossref","first-page":"H103","DOI":"10.1152\/ajpheart.00698.2021","article-title":"Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart","volume":"323","author":"Kawagishi","year":"2022","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2024011612162958800_ref12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1074-7613(00)80501-4","article-title":"Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis","volume":"5","author":"Fukada","year":"1996","journal-title":"Immunity"},{"key":"2024011612162958800_ref13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jare.2020.09.002","article-title":"Decreased PIBF1\/IL6\/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization","volume":"30","author":"Zhou","year":"2021","journal-title":"J Adv Res"},{"key":"2024011612162958800_ref14","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1210\/me.2012-1169","article-title":"Regulation of human endometrial stromal proliferation and differentiation by C\/EBPbeta involves cyclin E-cdk2 and STAT3","volume":"26","author":"Wang","year":"2012","journal-title":"Mol Endocrinol"},{"key":"2024011612162958800_ref15","doi-asserted-by":"crossref","first-page":"103623","DOI":"10.1016\/j.jri.2022.103623","article-title":"IL-27 promotes decidualization via the STAT3-ESR\/PGR regulatory axis","volume":"151","author":"Zhang","year":"2022","journal-title":"J Reprod Immunol"},{"key":"2024011612162958800_ref16","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1073\/pnas.0502343102","article-title":"Inhibition of Stat3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception","volume":"102","author":"Catalano","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024011612162958800_ref17","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab016","article-title":"Tofacitinib alters STAT3 signaling and leads to endometriosis lesion regression","volume":"27","author":"Kotlyar","year":"2021","journal-title":"Mol Hum Reprod"},{"key":"2024011612162958800_ref18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"2024011612162958800_ref19","first-page":"291","article-title":"Problems in the diagnosis of adenomyosis uteri; with special reference to dysfunctional bleeding","volume":"64","author":"Emge","year":"1956","journal-title":"West J Surg Obstet Gynecol"},{"key":"2024011612162958800_ref20","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac044","article-title":"Constant activation of STAT3 contributes to the development of adenomyosis in females","volume":"163","author":"Hiraoka","year":"2022","journal-title":"Endocrinology"},{"key":"2024011612162958800_ref21","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/humrep\/deu332","article-title":"Enhanced miR-210 expression promotes the pathogenesis of endometriosis through activation of signal transducer and activator of transcription 3","volume":"30","author":"Okamoto","year":"2015","journal-title":"Hum Reprod"},{"key":"2024011612162958800_ref22","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2353\/ajpath.2009.081011","article-title":"Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease","volume":"175","author":"Bacci","year":"2009","journal-title":"Am J Pathol"},{"key":"2024011612162958800_ref23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/imm.13574","article-title":"Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3\/Trib1\/ERK\/STAT3 signalling pathway in endometriosis","volume":"168","author":"Gou","year":"2023","journal-title":"Immunology"},{"key":"2024011612162958800_ref24","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1210\/en.2006-0264","article-title":"Interleukin 11 signaling components signal transducer and activator of transcription 3 (STAT3) and suppressor of cytokine signaling 3 (SOCS3) regulate human endometrial stromal cell differentiation","volume":"147","author":"Dimitriadis","year":"2006","journal-title":"Endocrinology"},{"key":"2024011612162958800_ref25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/rmb2.12088","article-title":"Decidualization of the human endometrium","volume":"17","author":"Okada","year":"2018","journal-title":"Reprod Med Biol"},{"key":"2024011612162958800_ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mrd.20149","article-title":"Differential expression and activation of Stat3 during mouse embryo implantation and decidualization","volume":"69","author":"Teng","year":"2004","journal-title":"Mol Reprod Dev"},{"key":"2024011612162958800_ref27","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1096\/fj.12-225664","article-title":"Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus","volume":"27","author":"Lee","year":"2013","journal-title":"FASEB J"},{"key":"2024011612162958800_ref28","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr Rev"},{"key":"2024011612162958800_ref29","doi-asserted-by":"crossref","first-page":"13735","DOI":"10.1038\/srep13735","article-title":"FoxM1 directs STAT3 expression essential for human endometrial stromal Decidualization","volume":"5","author":"Jiang","year":"2015","journal-title":"Sci Rep"},{"key":"2024011612162958800_ref30","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028415","article-title":"Interleukin-6 Family Cytokines","volume-title":"Cold Spring Harb Perspect Biol","author":"Rose-John","year":"2018"},{"key":"2024011612162958800_ref31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/bj3340297","article-title":"Interleukin-6-type cytokine signalling through the gp130\/Jak\/STAT pathway","volume":"334","author":"Heinrich","year":"1998","journal-title":"Biochem J"},{"key":"2024011612162958800_ref32","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jri.2010.03.003","article-title":"Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox a 10 in endometrial stromal cells","volume":"85","author":"Godbole","year":"2010","journal-title":"J Reprod Immunol"},{"key":"2024011612162958800_ref33","doi-asserted-by":"crossref","first-page":"23534","DOI":"10.1074\/jbc.M114.588897","article-title":"Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4","volume":"289","author":"Liang","year":"2014","journal-title":"J Biol Chem"},{"key":"2024011612162958800_ref34","doi-asserted-by":"crossref","first-page":"e21209","DOI":"10.1096\/fj.202002178R","article-title":"Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment","volume":"35","author":"Marquardt","year":"2021","journal-title":"FASEB J"},{"key":"2024011612162958800_ref35","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/molehr\/8.7.636","article-title":"Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells","volume":"8","author":"Dimitriadis","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"2024011612162958800_ref36","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1073\/pnas.151180898","article-title":"Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation","volume":"98","author":"Cheng","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024011612162958800_ref37","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1210\/en.2003-0585","article-title":"Immune-responsive gene 1 is a novel target of progesterone receptor and plays a critical role during implantation in the mouse","volume":"144","author":"Cheon","year":"2003","journal-title":"Endocrinology"},{"key":"2024011612162958800_ref38","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1074\/jbc.M310103200","article-title":"Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling","volume":"279","author":"Fairlie","year":"2004","journal-title":"J Biol Chem"},{"key":"2024011612162958800_ref39","doi-asserted-by":"crossref","first-page":"19357","DOI":"10.1073\/pnas.0710110104","article-title":"Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy","volume":"104","author":"White","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024011612162958800_ref40","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcp.29022","article-title":"N-glycosylation of uterine endometrium determines its receptivity","volume":"235","author":"Yu","year":"2020","journal-title":"J Cell Physiol"},{"key":"2024011612162958800_ref41","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1242\/bio.011890","article-title":"Dysregulated LIF-STAT3 pathway is responsible for impaired embryo implantation in a Streptozotocin-induced diabetic mouse model","volume":"4","author":"Wang","year":"2015","journal-title":"Biol Open"},{"key":"2024011612162958800_ref42","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1210\/en.2008-1538","article-title":"Interleukin-11 and leukemia inhibitory factor regulate the adhesion of endometrial epithelial cells: implications in fertility regulation","volume":"150","author":"Marwood","year":"2009","journal-title":"Endocrinology"},{"key":"2024011612162958800_ref43","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1095\/biolreprod.108.073601","article-title":"IL11 antagonist inhibits uterine stromal differentiation, causing pregnancy failure in mice","volume":"80","author":"Menkhorst","year":"2009","journal-title":"Biol Reprod"},{"key":"2024011612162958800_ref44","first-page":"1","article-title":"Decreased endometrial IL-10 impairs endometrial receptivity by downregulating HOXA10 expression in women with adenomyosis","volume":"2018","author":"Wang","year":"2018","journal-title":"Biomed Res Int"},{"key":"2024011612162958800_ref45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00404-015-3807-x","article-title":"The co-expression of GPER and Gankyrin in ovarian endometriosis and its correlation with the rASRM stages","volume":"293","author":"Zhang","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"2024011612162958800_ref46","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.canlet.2012.10.037","article-title":"Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN\/PI3K\/AKT signaling pathway","volume":"339","author":"Zhang","year":"2013","journal-title":"Cancer Lett"},{"key":"2024011612162958800_ref47","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1530\/REP-21-0199","article-title":"Gankyrin has a potential role in embryo implantation via activation of STAT3","volume":"163","author":"Yu","year":"2022","journal-title":"Reproduction"},{"key":"2024011612162958800_ref48","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1530\/REP-20-0187","article-title":"Cyclophilin a plays an important role in embryo implantation through activating Stat3","volume":"160","author":"Yu","year":"2020","journal-title":"Reproduction"},{"key":"2024011612162958800_ref49","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-018-0008-5","article-title":"Endometriosis","volume":"4","author":"Zondervan","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2024011612162958800_ref50","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/humupd\/dmab017","article-title":"Adenomyosis pathogenesis: insights from next-generation sequencing","volume":"27","author":"Bulun","year":"2021","journal-title":"Hum Reprod Update"},{"key":"2024011612162958800_ref51","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.fertnstert.2015.12.019","article-title":"Expression of GRIM-19 in adenomyosis and its possible role in pathogenesis","volume":"105","author":"Wang","year":"2016","journal-title":"Fertil Steril"},{"key":"2024011612162958800_ref52","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12690","article-title":"Hypoxia-inhibited DUSP2 expression promotes IL-6\/STAT3 signaling in endometriosis","volume":"78","author":"Hsiao","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"2024011612162958800_ref53","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/humrep\/dev050","article-title":"Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis","volume":"30","author":"Kim","year":"2015","journal-title":"Hum Reprod"},{"key":"2024011612162958800_ref54","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.fertnstert.2013.01.133","article-title":"Possible involvement of signal transducer and activator of transcription-3 in cell-cell interactions of peritoneal macrophages and endometrial stromal cells in human endometriosis","volume":"99","author":"Itoh","year":"2013","journal-title":"Fertil Steril"},{"key":"2024011612162958800_ref55","first-page":"2120","article-title":"FDA approves tofacitinib for rheumatoid arthritis","volume":"69","author":"Traynor","year":"2012","journal-title":"Am J Health Syst Pharm"},{"key":"2024011612162958800_ref56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cellsig.2017.04.001","article-title":"Niclosamide: beyond an antihelminthic drug","volume":"41","author":"Chen","year":"2018","journal-title":"Cell Signal"},{"key":"2024011612162958800_ref57","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1095\/biolreprod.116.140236","article-title":"Niclosamide as a potential nonsteroidal therapy for endometriosis that preserves reproductive function in an experimental mouse model","volume":"95","author":"Prather","year":"2016","journal-title":"Biol Reprod"},{"key":"2024011612162958800_ref58","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/humupd\/dmy020","article-title":"Is it time for a paradigm shift in drug research and development in endometriosis\/adenomyosis?","volume":"24","author":"Guo","year":"2018","journal-title":"Hum Reprod Update"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioad148\/53474350\/ioad148.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/110\/1\/5\/55674405\/ioad148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/110\/1\/5\/55674405\/ioad148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:27:33Z","timestamp":1705408053000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/110\/1\/5\/7334546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,10,31]]},"published-print":{"date-parts":[[2024,1,13]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioad148","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2023,10,31]]}}}