{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:11:12Z","timestamp":1762254672918,"version":"3.37.3"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00ES029548"],"award-info":[{"award-number":["R00ES029548"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Rochester Environmental Health Sciences Center"},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES001247"],"award-info":[{"award-number":["P30ES001247"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"KAH","award":["T32ES007062"],"award-info":[{"award-number":["T32ES007062"]}]},{"DOI":"10.13039\/100005185","name":"Millennium Challenge Corporation","doi-asserted-by":"publisher","award":["P42ES017198"],"award-info":[{"award-number":["P42ES017198"]}],"id":[{"id":"10.13039\/100005185","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Michigan Center for Lifestage Environmental Exposure and Disease","award":["P30ES017885"],"award-info":[{"award-number":["P30ES017885"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["5UL1TR000433"],"award-info":[{"award-number":["5UL1TR000433"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG067592"],"award-info":[{"award-number":["R01AG067592"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Global Alliance to Prevent Prematurity and Stillbirth","award":["912001"],"award-info":[{"award-number":["912001"]}]},{"DOI":"10.13039\/100009750","name":"University of Rochester Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Group B streptococcus (GBS) infection is a significant public health concern associated with adverse pregnancy complications and increased neonatal mortality and morbidity. However, the mechanisms underlying the impact of GBS on the fetal membrane, the first line of defense against pathogens, are not fully understood. Here, we propose that GBS induces senescence and inflammatory factors (IL-6 and IL-8) in the fetal membrane through interleukin-1 (IL-1). Utilizing the existing transcriptomic data on GBS-exposed human fetal membrane, we showed that GBS affects senescence-related pathways and genes. Next, we treated primary amnion epithelial cells with conditioned medium from the choriodecidual layer of human fetal membrane exposed to GBS (GBS collected choriodecidual [CD] conditioned medium) in the absence or presence of an IL-1 receptor antagonist (IL-1Ra). GBS CD conditioned medium significantly increased \u03b2-galactosidase activity, IL-6 and IL-8 release from the amnion epithelial cells. Cotreatment with IL1Ra reduced GBS-induced \u03b2-galactosidase activity and IL-6 and IL-8 secretion. Direct treatment with IL-1\u03b1 or IL-1\u03b2 confirmed the role of IL-1 signaling in the regulation of senescence in the fetal membrane. We further showed that GBS CD conditioned medium and IL-1 decreased cell proliferation in amnion epithelial cells. In summary, for the first time, we demonstrate GBS-induced senescence in the fetal membrane and present evidence of IL-1 pathway signaling between the choriodecidua and amnion layer of fetal membrane in a paracrine manner. Further studies will be warranted to understand the pathogenesis of adverse pregnancy outcomes associated with GBS infection and develop therapeutic interventions to mitigate these complications.<\/jats:p>","DOI":"10.1093\/biolre\/ioad149","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T23:25:23Z","timestamp":1698708323000},"page":"329-338","source":"Crossref","is-referenced-by-count":2,"title":["Group B streptococcus induces cellular senescence in human amnion epithelial cells through a partial interleukin-1-mediated mechanism"],"prefix":"10.1093","volume":"110","author":[{"given":"Hae-Ryung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine , School of Medicine and Dentistry, , Rochester, NY , USA"},{"name":"University of Rochester , School of Medicine and Dentistry, , Rochester, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly A","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Molecular Biology , Huck Institutes of the Life Sciences, , University Park, PA , USA"},{"name":"Pennsylvania State University , Huck Institutes of the Life Sciences, , University Park, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean M","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences , School of Public Health, , Ann Arbor, MI , USA"},{"name":"University of Michigan , School of Public Health, , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C","family":"Chames","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , School of Medicine, , Ann Arbor, MI , USA"},{"name":"University of Michigan , School of Medicine, , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Loch-Caruso","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences , School of Public Health, , Ann Arbor, MI , USA"},{"name":"University of Michigan , School of Public Health, , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"2024021704105279800_ref1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"2024021704105279800_ref2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many 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