{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:55:14Z","timestamp":1792688114297,"version":"4.5.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060294"],"award-info":[{"award-number":["82060294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recurrent spontaneous abortion (RSA) has various causes, including chromosomal abnormalities, prethrombotic state, and abnormal uterine anatomical factors. However, the pathogenesis of RSA is still unclear. Surprisingly, non-coding RNA can stably express at the maternal-fetal interface and regulate immune cells\u2019 proliferation, apoptosis, invasion, metastasis, and angiogenesis. Accumulating evidence suggests that the competing endogenous RNA (ceRNA) regulatory network between non-coding RNAs complicates RSA\u2019s pathological process and maybe a new starting point for exploring RSA. In this review, we mainly discuss the regulatory network and potential significance of non-coding RNA in the immune microenvironment of RSA patients. In addition, the cellular interactions of non-coding RNA transported through vesicles were introduced from aspects of trophoblast function and immune regulation. Finally, we analyze previous studies and further discuss that the stable expression of non-coding RNA may be used as a biomarker of some disease states and a prediction target of RSA.<\/jats:p>","DOI":"10.1093\/biolre\/ioad157","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T09:53:01Z","timestamp":1699609981000},"page":"220-229","source":"Crossref","is-referenced-by-count":12,"title":["Non-coding RNA regulates the immune microenvironment in recurrent spontaneous abortion (RSA): new insights into immune mechanisms"],"prefix":"10.1093","volume":"110","author":[{"given":"Cen","family":"Tang","sequence":"first","affiliation":[{"name":"Obstetrics Department, Kunming Medical University Second Affiliated Hospital , Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqin","family":"Hu","sequence":"additional","affiliation":[{"name":"Obstetrics Department, Kunming Medical University Second Affiliated Hospital , 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