{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:21:22Z","timestamp":1791559282719,"version":"4.3.4"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"publisher","award":["2019-67015-29704"],"award-info":[{"award-number":["2019-67015-29704"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006031","name":"Israel Binational Agricultural Research and Development Fund","doi-asserted-by":"crossref","award":["IS-1564-19"],"award-info":[{"award-number":["IS-1564-19"]}],"id":[{"id":"10.13039\/100006031","id-type":"DOI","asserted-by":"crossref"}]},{"name":"WI Experiment Station as Hatch Project","award":["WIS01240"],"award-info":[{"award-number":["WIS01240"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pregnancy loss (PL) in lactating dairy cows disrupts reproductive and productive efficiency. We evaluated the expression of interferon-stimulated genes (ISG) in blood leukocytes, vaginal and cervical epithelial cells, luteolysis-related genes, progesterone, and pregnancy-associated glycoprotein (PAG) profiles in lactating dairy cows (n\u2009=\u200986) to gain insight about PL. Expression of ISG on d17, d19, and d21 was greater in cows that maintained the pregnancy (P33) compared to nonpregnant with no PL (NP). Greater ISG differences between groups were observed in the cervix (96.7-fold) than vagina (31.0-fold), and least in blood leukocytes (5.6-fold). Based on individual profiles of ISG and PAG, PL was determined to occur either before (~13%) or after (~25%) d22. For cows with PL before d22, ISG expression was similar on d17 but by d21 was lower and OXTR was greater than P33 cows and similar to NP; timing of luteolysis was similar compared to NP cows suggesting embryonic failure to promote luteal maintenance and to attach to the endometrium (no increase in PAG). For cows with PL after d22, ISG expression was similar to P33 cows on d17, d19, and d21 and luteolysis, when it occurred, was later than NP cows; delayed increase in PAG suggested later or inadequate embryonic attachment. In conclusion, PL before d22 occurred due to embryonic demise\/failure to signal for luteal maintenance, as reflected in reduced ISG expression by d21. Alternatively, embryos with PL between d22 and 33 adequately signaled for luteal maintenance (ISG) but had delayed\/inadequate embryonic attachment and\/or inappropriate luteolysis causing PL.<\/jats:p>","DOI":"10.1093\/biolre\/ioad164","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T01:17:18Z","timestamp":1701998238000},"page":"558-568","source":"Crossref","is-referenced-by-count":22,"title":["Profiles of interferon-stimulated genes in multiple tissues and circulating pregnancy-associated glycoproteins and their association with pregnancy loss in dairy cows"],"prefix":"10.1093","volume":"110","author":[{"given":"Rafael R","family":"Domingues","sequence":"first","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]},{"name":"Endocrinology and Reproductive Physiology Program, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Paulo N","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago O","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Madureira","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August S","family":"Hoppman","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia N","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L J","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H","family":"Gomez-Leon","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]},{"name":"Department of Animal Sciences and Industry, Kansas State University , Manhattan, Kansas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Paulo N","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences , School of Veterinary Medicine, , Madison, Wisconsin ,","place":["USA"]},{"name":"University of Wisconsin\u2013Madison , School of Veterinary Medicine, , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo C","family":"Wiltbank","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]},{"name":"Endocrinology and Reproductive Physiology Program, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"2024121102544998700_ref1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.theriogenology.2016.04.037","article-title":"Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows","volume":"86","author":"Wiltbank","year":"2016","journal-title":"Theriogenology"},{"key":"2024121102544998700_ref2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.anireprosci.2004.04.015","article-title":"The effect of embryonic death rates in cattle on the efficacy of estrus synchronization programs","volume":"82","author":"Santos","year":"2004","journal-title":"Anim Reprod Sci"},{"key":"2024121102544998700_ref3","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.3168\/jds.2023-23445","article-title":"Perspective: can early embryonic losses be reduced in lactating dairy 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