{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:13:23Z","timestamp":1774671203409,"version":"3.50.1"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100018095","name":"Virginia-Maryland College of Veterinary Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Placental angiogenesis is critical for normal development. Angiogenic factors and their receptors are key regulators of this process. Dysregulated placental vascular development is associated with pregnancy complications. Despite their importance, vascular growth factor expression has not been thoroughly correlated with placental morphologic development across gestation in cats. We postulate that changes in placental vessel morphology can be appreciated as consequences of dynamic expression of angiogenic signaling agents. Here, we characterized changes in placental morphology alongside expression analysis of angiogenic factor splice variants and receptors throughout pregnancy in domestic shorthair cats. We observed increased vascular and lamellar density in the lamellar zone during mid-pregnancy. Immunohistochemical analysis localized the vascular endothelial growth factor A (VEGF-A) receptor KDR to endothelial cells of the maternal and fetal microvasculatures. PlGF and its principal receptor Flt-1 were localized to the trophoblasts and fetal vasculature. VEGF-A was found in trophoblast cells and associated with endothelial cells. We detected expression of two Plgf splice variants and four Vegf-a variants. Quantitative real-time polymerase chain reaction analysis showed upregulation of mRNAs encoding pan Vegf-a and all Vegf-a splice forms at gestational days 30\u201335. Vegf-A showed a marked relative increase in expression during mid-pregnancy, consistent with the pro-angiogenic changes seen in the lamellar zone at days 30\u201335. Flt-1 was upregulated during late pregnancy. Plgf variants showed stable expression during the first two-thirds of pregnancy, followed by a marked increase toward term. These findings revealed specific spatiotemporal expression patterns of VEGF-A family members consistent with pivotal roles during normal placental development.<\/jats:p>","DOI":"10.1093\/biolre\/ioad167","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T23:47:11Z","timestamp":1702511231000},"page":"569-582","source":"Crossref","is-referenced-by-count":6,"title":["Morphological evaluation of the feline placenta correlates with gene expression of vascular growth factors and receptors"],"prefix":"10.1093","volume":"110","author":[{"given":"Erwin K","family":"Gudenschwager-Basso","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences & Pathobiology, Virginia\u2013Maryland College of Veterinary Medicine , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galit","family":"Frydman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences & Pathobiology, Virginia\u2013Maryland College of Veterinary Medicine , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaneke","family":"Weerakoon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences & Pathobiology, Virginia\u2013Maryland College of Veterinary Medicine , Blacksburg, VA , USA"},{"name":"Virginia Tech Carilion School of Medicine, Virginia Tech , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hariyat","family":"Andargachew","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences & Pathobiology, Virginia\u2013Maryland College of Veterinary Medicine , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra M","family":"Piltaver","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences & Pathobiology, Virginia\u2013Maryland College of Veterinary Medicine , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R","family":"Huckle","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences & Pathobiology, Virginia\u2013Maryland College of Veterinary Medicine , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"2024031509554293900_ref1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-3-642-23941-0_4","volume-title":"Pathology of the Human Placenta","author":"Benirschke","year":"2012"},{"key":"2024031509554293900_ref2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1387\/ijdb.082799lr","article-title":"Uteroplacental vascular development and placental function: an update","volume":"54","author":"Reynolds","year":"2010","journal-title":"Int J Dev Biol"},{"key":"2024031509554293900_ref3","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/jcb.21523","article-title":"Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling","volume":"102","author":"Semenza","year":"2007","journal-title":"J Cell Biochem"},{"key":"2024031509554293900_ref4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000063690","article-title":"Vasculogenesis, angiogenesis and the molecular organisation of endothelial junctions in the early human placenta","volume":"39","author":"Leach","year":"2002","journal-title":"J Vasc Res"},{"key":"2024031509554293900_ref5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.placenta.2017.07.052","article-title":"Hematopoiesis vasculogenesis and angiogenesis in first trimester placenta","volume":"57","author":"Aplin","year":"2017","journal-title":"Placenta"},{"key":"2024031509554293900_ref6","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1095\/biolreprod64.4.1033","article-title":"Angiogenesis in the placenta","volume":"64","author":"Reynolds","year":"2001","journal-title":"Biol Reprod"},{"key":"2024031509554293900_ref7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00404-007-0453-y","article-title":"Placenta: angiogenesis and vascular assessment through three-dimensional power Doppler ultrasonography","volume":"277","author":"Guimaraes Filho","year":"2008","journal-title":"Arch Gynecol Obstet"},{"key":"2024031509554293900_ref8","doi-asserted-by":"crossref","first-page":"e89419","DOI":"10.1371\/journal.pone.0089419","article-title":"Placental pathology, perinatal death, neonatal outcome, and neurological development: a systematic review","volume":"9","author":"Roescher","year":"2014","journal-title":"PloS One"},{"key":"2024031509554293900_ref9","first-page":"4010339","article-title":"Value of ultrasonic image features in diagnosis of perinatal outcomes of severe preeclampsia on account of deep learning algorithm","volume":"2022","author":"Wang","year":"2022","journal-title":"Comput Math Methods Med"},{"key":"2024031509554293900_ref10","doi-asserted-by":"crossref","first-page":"H1393","DOI":"10.1152\/ajpheart.00767.2020","article-title":"Postpartum microvascular functional alterations following severe preeclampsia","volume":"320","author":"Barr","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2024031509554293900_ref11","doi-asserted-by":"crossref","first-page":"101483","DOI":"10.1016\/j.genrep.2021.101483","article-title":"Abnormal angiogenesis associated with HIF-1\u03b1\/VEGF signaling pathway in recurrent miscarriage along with therapeutic goals","volume":"26","author":"Taghizadeh","year":"2022","journal-title":"Gene Reports"},{"key":"2024031509554293900_ref12","first-page":"88","article-title":"Development of the trophoblast in the early carnivore placenta as exemplified by the cat","volume":"111","author":"Leiser","year":"1981","journal-title":"Acta Anat"},{"key":"2024031509554293900_ref13","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.theriogenology.2006.02.027","article-title":"The carnivore pregnancy: the development of the embryo and fetal membranes","volume":"66","author":"Miglino","year":"2006","journal-title":"Theriogenology"},{"key":"2024031509554293900_ref14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ar.1091650103","article-title":"Ultrastructure of the placenta and fetal membranes of the dog. I. The placental labyrinth","volume":"165","author":"Anderson","year":"1969","journal-title":"Anat Rec"},{"key":"2024031509554293900_ref15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/aja.1001430106","article-title":"Development of the implantation chamber in the pregnant bitch","volume":"143","author":"Barrau","year":"1975","journal-title":"Am J Anat"},{"key":"2024031509554293900_ref16","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/jez.1402660612","article-title":"Development and characteristics of placentation in a carnivore, the domestic cat","volume":"266","author":"Leiser","year":"1993","journal-title":"J Exp Zool"},{"key":"2024031509554293900_ref17","first-page":"279","article-title":"Microvascularization of the placenta of a cat","volume":"112","author":"Leiser","year":"1982","journal-title":"Acta Anat"},{"key":"2024031509554293900_ref18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00319006","article-title":"The blood-vessels of the cat girdle placenta\u2014observations on corrosion casts, scanning electron microscopical and histological studies. II. Fetal vasculature","volume":"170","author":"Leiser","year":"1984","journal-title":"Anat Embryol"},{"key":"2024031509554293900_ref19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1439-0264.1979.tb00681.x","article-title":"Blastocyst implantation in the domestic cat. Light and electron microscopic study","volume":"8","author":"Leiser","year":"1979","journal-title":"Anat Histol Embryol"},{"key":"2024031509554293900_ref20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00519908","article-title":"Chorionic development and structure of the placenta zonaria in the cat, dog and fox (author\u2019s transl)","volume":"143","author":"Kehrer","year":"1973","journal-title":"Z Anat Entwicklungsgesch"},{"key":"2024031509554293900_ref21","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1053\/plac.1999.0525","article-title":"Angiogenesis in embryonic development\u2014a review","volume":"21 Suppl A","author":"Breier","year":"2000","journal-title":"Placenta"},{"key":"2024031509554293900_ref22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1053\/plac.2001.0627","article-title":"Developmental expression of vascular endothelial growth factor (VEGF) receptors and VEGF binding in ovine placenta and fetal membranes","volume":"22","author":"Bogic","year":"2001","journal-title":"Placenta"},{"key":"2024031509554293900_ref23","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.placenta.2003.11.011","article-title":"Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis","volume":"25","author":"Demir","year":"2004","journal-title":"Placenta"},{"key":"2024031509554293900_ref24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1053\/plac.1998.0350","article-title":"Immunohistochemical localization of vascular endothelial growth factor (VEGF) and its two specific receptors, Flt-1 and KDR, in the porcine placenta and non-pregnant uterus","volume":"20","author":"Winther","year":"1999","journal-title":"Placenta"},{"key":"2024031509554293900_ref25","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.febslet.2005.01.017","article-title":"Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism","volume":"579","author":"Yao","year":"2005","journal-title":"FEBS Lett"},{"key":"2024031509554293900_ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3858\/emm.2012.44.1.025","article-title":"The discovery of placenta growth factor and its biological activity","volume":"44","author":"De Falco","year":"2012","journal-title":"Exp Mol Med"},{"key":"2024031509554293900_ref27","first-page":"15","article-title":"Vascular endothelial growth factor and the regulation of angiogenesis","volume":"55","author":"Ferrara","year":"2000","journal-title":"Recent Prog Horm Res"},{"key":"2024031509554293900_ref28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/vetsci9070375","article-title":"Characterization of the expression of angiogenic factors in cutaneous squamous cell carcinoma of domestic cats","volume":"9","author":"Gudenschwager-Basso","year":"2022","journal-title":"Vet Sci"},{"key":"2024031509554293900_ref29","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1210\/mend-5-12-1806","article-title":"The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA","volume":"5","author":"Houck","year":"1991","journal-title":"Mol Endocrinol"},{"key":"2024031509554293900_ref30","doi-asserted-by":"crossref","first-page":"11947","DOI":"10.1016\/S0021-9258(18)99049-6","article-title":"The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing","volume":"266","author":"Tischer","year":"1991","journal-title":"J Biol Chem"},{"key":"2024031509554293900_ref31","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1091\/mbc.4.12.1317","article-title":"The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF","volume":"4","author":"Park","year":"1993","journal-title":"Mol Biol Cell"},{"key":"2024031509554293900_ref32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat Med"},{"key":"2024031509554293900_ref33","doi-asserted-by":"crossref","first-page":"12081","DOI":"10.1073\/pnas.94.22.12081","article-title":"Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189","volume":"94","author":"Cheng","year":"1997","journal-title":"Proc Natl Acad Sci"},{"key":"2024031509554293900_ref34","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1128\/MCB.20.19.7282-7291.2000","article-title":"Isoforms of vascular endothelial growth factor act in a coordinate fashion to recruit and expand tumor vasculature","volume":"20","author":"Grunstein","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2024031509554293900_ref35","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1101\/gad.242002","article-title":"Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis","volume":"16","author":"Ruhrberg","year":"2002","journal-title":"Genes Dev"},{"key":"2024031509554293900_ref36","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1158\/0008-5472.CAN-07-2011","article-title":"Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform\u2013producing tumors","volume":"68","author":"Tozer","year":"2008","journal-title":"Cancer Res"},{"key":"2024031509554293900_ref37","first-page":"1838","article-title":"Vascular endothelial growth factor isoform expression as a determinant of blood vessel patterning in human melanoma xenografts","volume":"62","author":"Yu","year":"2002","journal-title":"Cancer Res"},{"key":"2024031509554293900_ref38","first-page":"5408","article-title":"Differential effects of vascular endothelial growth factor a isoforms in a mouse brain metastasis model of human melanoma","volume":"63","author":"K\u00fcsters","year":"2003","journal-title":"Cancer Res"},{"key":"2024031509554293900_ref39","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/8379","article-title":"Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF 164 and VEGF 188","volume":"5","author":"Carmeliet","year":"1999","journal-title":"Nat Med"},{"key":"2024031509554293900_ref40","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.theriogenology.2004.02.009","article-title":"Correlation between fetal age and ultrasonographic measurements during the second half of pregnancy in domestic cats (Felis catus)","volume":"62","author":"Zambelli","year":"2004","journal-title":"Theriogenology"},{"key":"2024031509554293900_ref41","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/S0093-691X(01)00686-0","article-title":"Correlation between the age of the conceptus and various ultrasonographic measurements during the first 30 days of pregnancy in domestic cats (Felis catus)","volume":"57","author":"Zambelli","year":"2002","journal-title":"Theriogenology"},{"key":"2024031509554293900_ref42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-3-540-78797-6_7","volume-title":"Comparative Placentation: Structures, Functions and Evolution","author":"Wooding","year":"2008"},{"key":"2024031509554293900_ref43","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation\u2014a review","volume":"28","author":"Carter","year":"2007","journal-title":"Placenta"},{"key":"2024031509554293900_ref44","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.2527\/1995.7361839x","article-title":"Utero-placental vascular development and placental function","volume":"73","author":"Reynolds","year":"1995","journal-title":"J Anim Sci"},{"key":"2024031509554293900_ref45","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1530\/REP-09-0092","article-title":"Regulation of vascular growth and function in the human placenta","volume":"138","author":"Burton","year":"2009","journal-title":"Reproduction"},{"key":"2024031509554293900_ref46","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1093\/advances\/nmab070","article-title":"Placental angiogenesis in mammals: a review of the regulatory effects of signaling pathways and functional nutrients","volume":"12","author":"Huang","year":"2021","journal-title":"Adv Nutr"},{"key":"2024031509554293900_ref47","first-page":"3","article-title":"Morphometry of the placental exchange area","volume":"53","author":"Baur","year":"1977","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"2024031509554293900_ref48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.placenta.2008.11.006","article-title":"Evolution of factors affecting placental oxygen transfer","volume":"30","author":"Carter","year":"2009","journal-title":"Placenta"},{"key":"2024031509554293900_ref49","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1055\/s-0029-1211275","article-title":"Placental structure: in a comparative aspect","volume":"102","author":"Leiser","year":"1994","journal-title":"Exp Clin Endocrinol"},{"key":"2024031509554293900_ref50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/biolre\/ioab061","article-title":"Kisspeptin\/Kiss1r system and angiogenic and immunological mediators at the maternal-fetal interface of domestic cats","volume":"105","author":"Santos","year":"2021","journal-title":"Biol Reprod"},{"key":"2024031509554293900_ref51","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1095\/biolreprod66.3.802","article-title":"Hemochorial placentation in the primate: expression of vascular endothelial growth factor, angiopoietins, and their receptors throughout pregnancy","volume":"66","author":"Wulff","year":"2002","journal-title":"Biol Reprod"},{"key":"2024031509554293900_ref52","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.placenta.2005.09.004","article-title":"Localization of vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and VEGFR-2 in bovine placentomes from implantation until term","volume":"27","author":"Pfarrer","year":"2006","journal-title":"Placenta"},{"key":"2024031509554293900_ref53","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/oxfordjournals.humrep.a019303","article-title":"Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy","volume":"11","author":"Clark","year":"1996","journal-title":"Hum Reprod"},{"key":"2024031509554293900_ref54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0303-7207(02)00190-9","article-title":"Co-expression of vascular endothelial growth factor and neuropilin-1 in ovine feto-placental artery endothelial cells","volume":"196","author":"Tsoi","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"2024031509554293900_ref55","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1095\/biolreprod.106.054684","article-title":"Placental growth throughout the last two thirds of pregnancy in sheep: vascular development and angiogenic factor expression","volume":"76","author":"Borowicz","year":"2007","journal-title":"Biol Reprod"},{"key":"2024031509554293900_ref56","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ygcen.2015.09.020","article-title":"Expression and localization of vascular endothelial growth factor A (VEGFA) and its two receptors (VEGFR1\/FLT1 and VEGFR2\/FLK1\/KDR) in the canine corpus luteum and utero-placental compartments during pregnancy and at normal and induced parturition","volume":"223","author":"Gram","year":"2015","journal-title":"Gen Comp Endocrinol"},{"key":"2024031509554293900_ref57","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/107155769700400401","article-title":"Vascular endothelial growth factor: possible role in fetal development and placental function","volume":"4","author":"Cheung","year":"1997","journal-title":"J Soc Gynecol Investig"},{"key":"2024031509554293900_ref58","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1095\/biolreprod64.6.1821","article-title":"Relationship between placental vascular endothelial growth factor expression and placental\/endometrial vascularity in the pig","volume":"64","author":"Vonnahme","year":"2001","journal-title":"Biol Reprod"},{"key":"2024031509554293900_ref59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.theriogenology.2015.02.009","article-title":"Expression of hypoxia-inducible factors and vascular endothelial growth factor during pregnancy in the feline uterus","volume":"84","author":"Agaoglu","year":"2015","journal-title":"Theriogenology"},{"key":"2024031509554293900_ref60","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1074\/jbc.M211390200","article-title":"Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner: evidence for differential function of HIFs during early pregnancy","volume":"278","author":"Daikoku","year":"2003","journal-title":"J Biol Chem"},{"key":"2024031509554293900_ref61","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0093-691X(87)90205-6","article-title":"Reproductive hormone concentrations during estrus, pregnancy, and pseudopregnancy in the Labrador bitch","volume":"27","author":"Chakraborty","year":"1987","journal-title":"Theriogenology"},{"key":"2024031509554293900_ref62","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1095\/biolreprod14.5.579","article-title":"Plasma levels of estradiol and progesterone in the cat during polyestrus, pregnancy and pseudopregnancy","volume":"14","author":"Verhage","year":"1976","journal-title":"Biol Reprod"},{"key":"2024031509554293900_ref63","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1073\/pnas.082110999","article-title":"A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus","volume":"99","author":"Ancelin","year":"2002","journal-title":"Proc Natl Acad Sci"},{"key":"2024031509554293900_ref64","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1289\/ehp.00108s5785","article-title":"Regulation of vascular endothelial growth factor expression by estrogens and progestins","volume":"108","author":"Hyder","year":"2000","journal-title":"Environ Health Perspect"},{"key":"2024031509554293900_ref65","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1210\/mend.15.11.0734","article-title":"Adult tissue angiogenesis: evidence for negative regulation by estrogen in the uterus","volume":"15","author":"Ma","year":"2001","journal-title":"Mol Endocrinol"},{"key":"2024031509554293900_ref66","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/bs.ctdb.2016.10.001","article-title":"VEGF receptor tyrosine kinases: key regulators of vascular function","volume":"123","author":"\u00c1lvarez-Aznar","year":"2017","journal-title":"Curr Top Dev Biol"},{"key":"2024031509554293900_ref67","doi-asserted-by":"crossref","first-page":"e013238","DOI":"10.1161\/JAHA.119.013238","article-title":"Vascular endothelial growth factor-121 administration mitigates halogen inhalation-induced pulmonary injury and fetal growth restriction in pregnant mice","volume":"9","author":"Addis","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2024031509554293900_ref68","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1210\/jc.2003-031580","article-title":"Differential expression of VEGF, EG-VEGF, and VEGF receptors in human placentas from normal and pre-eclamptic pregnancies","volume":"89","author":"Chung","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2024031509554293900_ref69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1526-968X(200003)26:3<213::AID-GENE7>3.0.CO;2-M","article-title":"Differential expression of VEGF isoforms and VEGF164-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF164 in vascular permeability and angiogenesis during implantation","volume":"26","author":"Halder","year":"2000","journal-title":"Genesis"},{"key":"2024031509554293900_ref70","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/08977199609003225","article-title":"Localisation of placenta growth factor (PlGF) in human term placenta","volume":"13","author":"Khaliq","year":"1996","journal-title":"Growth Factors"},{"key":"2024031509554293900_ref71","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1095\/biolreprod56.2.489","article-title":"Expression of vascular endothelial growth factor and placenta growth factor in human placenta","volume":"56","author":"Vuorela","year":"1997","journal-title":"Biol Reprod"},{"key":"2024031509554293900_ref72","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-642-59953-8_2","volume-title":"Vascular Growth Factors and Angiogenesis","author":"Persico","year":"1999"},{"key":"2024031509554293900_ref73","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1530\/REP-10-0505","article-title":"Placental development during early pregnancy in sheep: cell proliferation, global methylation, and angiogenesis in the fetal placenta","volume":"141","author":"Grazul-Bilska","year":"2011","journal-title":"Reproduction"},{"key":"2024031509554293900_ref74","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/uog.15807","article-title":"Contingent screening for preterm pre-eclampsia","volume":"47","author":"Wright","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2024031509554293900_ref75","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4142\/jvs.2005.6.3.179","article-title":"Expression of placenta growth factor mRNA in the rat placenta during mid-late pregnancy","volume":"6","author":"Choi","year":"2005","journal-title":"J Vet Sci"},{"key":"2024031509554293900_ref76","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejogrb.2018.03.059","article-title":"Systematic review of maternal placental growth factor levels in late pregnancy as a predictor of adverse intrapartum and perinatal outcomes","volume":"225","author":"Sherrell","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2024031509554293900_ref77","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.preghy.2013.01.004","article-title":"Determination of placental growth factor (PlGF) levels in healthy pregnant women without signs or symptoms of preeclampsia","volume":"3","author":"Saffer","year":"2013","journal-title":"Pregnancy Hypertens"},{"key":"2024031509554293900_ref78","doi-asserted-by":"crossref","first-page":"35172","DOI":"10.1074\/jbc.274.49.35172","article-title":"Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis","volume":"274","author":"Yonekura","year":"1999","journal-title":"J Biol Chem"},{"key":"2024031509554293900_ref79","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/sj.bjp.0706347","article-title":"Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia","volume":"146","author":"Bellik","year":"2005","journal-title":"Br J Pharmacol"},{"key":"2024031509554293900_ref80","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041388","article-title":"Role of VEGFs\/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models","volume":"21","author":"Ceci","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioad167\/55574439\/ioad167.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/110\/3\/569\/56956245\/ioad167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/110\/3\/569\/56956245\/ioad167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T09:56:49Z","timestamp":1710496609000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/110\/3\/569\/7471843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":80,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,12,13]]},"published-print":{"date-parts":[[2024,3,13]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioad167","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2023,12,13]]}}}