{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:37:46Z","timestamp":1783021066332,"version":"3.54.6"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD094513"],"award-info":[{"award-number":["R01 HD094513"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stanford Discovery and Innovation Foundation Grant"},{"name":"A.P. Giannini Foundation Postdoctoral Fellowship"},{"name":"Stanford Child Health Research Institute Postdoctoral Award"},{"name":"Stanford Dean\u2019s Postdoctoral Fellowship"},{"DOI":"10.13039\/100023581","name":"National Science Foundation Graduate Research Fellowship Program","doi-asserted-by":"publisher","award":["DGE-1656518"],"award-info":[{"award-number":["DGE-1656518"]}],"id":[{"id":"10.13039\/100023581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Uterine injury from procedures such as Cesarean sections (C-sections) often have severe consequences on subsequent pregnancy outcomes, leading to disorders such as placenta previa, placenta accreta, and infertility. With rates of C-section at ~30% of deliveries in the USA and projected to continue to climb, a deeper understanding of the mechanisms by which these pregnancy disorders arise and opportunities for intervention are needed. Here we describe a rodent model of uterine injury on subsequent in utero outcomes. We observed three distinct phenotypes: increased rates of resorption and death, embryo spacing defects, and placenta accreta-like features of reduced decidua and expansion of invasive trophoblasts. We show that the appearance of embryo spacing defects depends entirely on the phase of estrous cycle at the time of injury. Using RNA-seq, we identified perturbations in the expression of components of the COX\/prostaglandin pathway after recovery from injury, a pathway that has previously been demonstrated to play an important role in embryo spacing. Therefore, we demonstrate that uterine damage in this mouse model causes morphological and molecular changes that ultimately lead to placental and embryonic developmental defects.<\/jats:p>","DOI":"10.1093\/biolre\/ioae001","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T07:17:40Z","timestamp":1704871060000},"page":"819-833","source":"Crossref","is-referenced-by-count":5,"title":["Uterine injury during diestrus leads to placental and embryonic defects in future pregnancies in mice"],"prefix":"10.1093","volume":"110","author":[{"given":"Elisa T","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Genetics, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen L","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby J","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars M","family":"Steinmetz","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]},{"name":"Stanford Genome Technology Center, Stanford University , Palo Alto, CA ,","place":["USA"]},{"name":"European Molecular Biology Laboratory (EMBL), Genome Biology Unit , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"2025011101232898200_ref1","doi-asserted-by":"crossref","first-page":"e031193","DOI":"10.1136\/bmjopen-2019-031193","article-title":"Epidemiology of placenta previa accreta: a systematic review and meta-analysis","volume":"9","author":"Jauniaux","year":"2019","journal-title":"BMJ Open"},{"key":"2025011101232898200_ref2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ogc.2012.12.002","article-title":"Placenta accreta, increta, and percreta","volume":"40","author":"Wortman","year":"2013","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2025011101232898200_ref3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052893","article-title":"Incidence and risk factors for placenta accreta\/increta\/percreta in the UK: a national case-control study","volume":"7","author":"Fitzpatrick","year":"2012","journal-title":"PloS One"},{"key":"2025011101232898200_ref4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ogc.2015.01.014","article-title":"Placenta accreta spectrum: accreta, increta, and percreta","volume":"42","author":"Silver","year":"2015","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2025011101232898200_ref5","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.ajog.2004.12.074","article-title":"Abnormal placentation: twenty-year analysis","volume":"192","author":"Wu","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"2025011101232898200_ref6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bpobgyn.2012.10.003","article-title":"Caesarean section in cases of placenta praevia and accreta","volume":"27","author":"Palacios-Jaraquemada","year":"2013","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2025011101232898200_ref7","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.placenta.2011.11.010","article-title":"Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease","volume":"33","author":"Jauniaux","year":"2012","journal-title":"Placenta"},{"key":"2025011101232898200_ref8","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3109\/14767058.2011.553695","article-title":"The effect of cesarean delivery rates on the future incidence of placenta previa, placenta accreta, and maternal mortality","volume":"24","author":"Solheim","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2025011101232898200_ref9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0002-9378(97)70463-0","article-title":"Clinical risk factors for placenta previa-placenta accreta","volume":"177","author":"Miller","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"2025011101232898200_ref10","first-page":"799","article-title":"Risk factors for placenta accreta: a large prospective cohort","volume":"31","author":"Bowman","year":"2014","journal-title":"Am J Perinatol"},{"key":"2025011101232898200_ref11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1034\/j.1600-0412.1999.780301.x","article-title":"Histopathological study of placental bed biopsy in placenta previa","volume":"78","author":"Biswas","year":"1999","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2025011101232898200_ref12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.placenta.2008.04.008","article-title":"Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast","volume":"29","author":"Tantbirojn","year":"2008","journal-title":"Placenta"},{"key":"2025011101232898200_ref13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0143-4004(87)90067-1","article-title":"Placenta creta and placenta praevia creta","volume":"8","author":"Khong","year":"1987","journal-title":"Placenta"},{"key":"2025011101232898200_ref14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2350\/15-05-1641-OA.1","article-title":"Placenta Accreta and placenta increta: an approach to pathogenesis based on the trophoblastic differentiation pathway","volume":"19","author":"Cramer","year":"2016","journal-title":"Pediatr Dev Pathol"},{"key":"2025011101232898200_ref15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.placenta.2018.08.003","article-title":"Chorion laeve accreta - another manifestation of morbid adherence","volume":"74","author":"Khong","year":"2018","journal-title":"Placenta"},{"key":"2025011101232898200_ref16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2350\/06-10-0174.1","article-title":"Occult placenta accreta: the missing link in the diagnosis of abnormal placentation","volume":"10","author":"Stanek","year":"2007","journal-title":"Pediatr Dev Pathol"},{"key":"2025011101232898200_ref17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2353\/ajpath.2010.091209","article-title":"Myometrial wound healing post-Cesarean delivery in the MRL\/MpJ mouse model of uterine scarring","volume":"177","author":"Buhimschi","year":"2010","journal-title":"Am J Pathol"},{"key":"2025011101232898200_ref18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.placenta.2020.06.006","article-title":"A mouse model of placenta accreta spectrum","volume":"99","author":"Burke","year":"2020","journal-title":"Placenta"},{"key":"2025011101232898200_ref19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1530\/jrf.0.0190239","article-title":"Implantation and development of mouse eggs transferred to the uteri of non-progestational mice","volume":"19","author":"Cowell","year":"1969","journal-title":"J Reprod Fertil"},{"key":"2025011101232898200_ref20","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa174","article-title":"Uterine scarring leads to adverse pregnant consequences by impairing the endometrium response to steroids","volume":"161","author":"Li","year":"2020","journal-title":"Endocrinology"},{"key":"2025011101232898200_ref21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40738-020-00074-3","article-title":"Staging of the estrous cycle and induction of estrus in experimental rodents: an update","volume":"6","author":"Ajayi","year":"2020","journal-title":"Fertil Res Pract"},{"key":"2025011101232898200_ref22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-394445-0.00007-2","volume-title":"The Guide to Investigation of Mouse Pregnancy","author":"Bertolin","year":"2014"},{"key":"2025011101232898200_ref23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.celrep.2014.06.027","article-title":"Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling","volume":"8","author":"Cha","year":"2014","journal-title":"Cell Rep"},{"key":"2025011101232898200_ref24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature03505","article-title":"LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing","volume":"435","author":"Ye","year":"2005","journal-title":"Nature"},{"key":"2025011101232898200_ref25","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1242\/dev.129.12.2879","article-title":"Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development","volume":"129","author":"Song","year":"2002","journal-title":"Development"},{"key":"2025011101232898200_ref26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/rep.0.1260559","article-title":"Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium","volume":"126","author":"Sales","year":"2003","journal-title":"Reproduction"},{"key":"2025011101232898200_ref27","doi-asserted-by":"crossref","first-page":"714042","DOI":"10.3389\/fimmu.2021.714042","article-title":"Prostanoids and resolution of inflammation - beyond the lipid-mediator class switch","volume":"12","author":"Schmid","year":"2021","journal-title":"Front Immunol"},{"key":"2025011101232898200_ref28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fphar.2016.00316","article-title":"Pharmacogenomics of prostaglandin and leukotriene receptors","volume":"7","author":"Cornejo-Garcia","year":"2016","journal-title":"Front Pharmacol"},{"key":"2025011101232898200_ref29","first-page":"3966","article-title":"Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition","volume":"118","author":"Fetalvero","year":"2008","journal-title":"J Clin Invest"},{"key":"2025011101232898200_ref30","first-page":"H796","article-title":"Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle","volume":"267","author":"Williams","year":"1994","journal-title":"Am J Physiol"},{"key":"2025011101232898200_ref31","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1038\/s41598-019-42181-2","article-title":"Oxytocin receptor antagonists, atosiban and nolasiban, inhibit prostaglandin F2alpha-induced contractions and inflammatory responses in human myometrium","volume":"9","author":"Kim","year":"2019","journal-title":"Sci Rep"},{"key":"2025011101232898200_ref32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12894-020-00619-0","article-title":"The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor","volume":"20","author":"Stromberga","year":"2020","journal-title":"BMC Urol"},{"key":"2025011101232898200_ref33","first-page":"563","article-title":"Uterine relaxant effects of cyclooxygenase-2 inhibitors in vitro","volume":"98","author":"Slattery","year":"2001","journal-title":"Obstet Gynecol"},{"key":"2025011101232898200_ref34","first-page":"e4389","article-title":"Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification","volume":"67","author":"McLean","year":"2012","journal-title":"J Vis Exp"},{"key":"2025011101232898200_ref35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2025011101232898200_ref36","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2025011101232898200_ref37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2025011101232898200_ref38","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"2025011101232898200_ref39","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1095\/biolreprod16.3.286","article-title":"Evidence for a role for prosaglandins in the initiation of blastocyst implantation in the rat","volume":"16","author":"Kennedy","year":"1977","journal-title":"Biol Reprod"},{"key":"2025011101232898200_ref40","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1172\/JCI28462","article-title":"Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice","volume":"116","author":"Li","year":"2006","journal-title":"J Clin Invest"},{"key":"2025011101232898200_ref41","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/biolre\/iox101","article-title":"Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium","volume":"97","author":"Matson","year":"2017","journal-title":"Biol Reprod"},{"key":"2025011101232898200_ref42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejphar.2005.06.001","article-title":"Adrenomedullin modulates COX-2 and HGF expression in reserpine-injured gastric mucosa in the rat","volume":"518","author":"Cantarella","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"2025011101232898200_ref43","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.2042-7158.1991.tb03480.x","article-title":"Lysophosphatidic acids induce contraction of rat isolated colon by two different mechanisms","volume":"43","author":"Tokumura","year":"1991","journal-title":"J Pharm Pharmacol"},{"key":"2025011101232898200_ref44","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1152\/jappl.1997.83.4.1216","article-title":"Lysophosphatidic acid enhances contractility of isolated airway smooth muscle","volume":"83","author":"Toews","year":"1997","journal-title":"J Appl Physiol"},{"key":"2025011101232898200_ref45","first-page":"74","article-title":"Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregnant rats","volume":"245","author":"Tokumura","year":"1980","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"2025011101232898200_ref46","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1002\/anie.200454065","article-title":"Identifying specific conformations by using a carbohydrate scaffold: discovery of subtype-selective LPA-receptor agonists and an antagonist","volume":"43","author":"Tamaruya","year":"2004","journal-title":"Angew Chem Int Ed Engl"},{"key":"2025011101232898200_ref47","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1095\/biolreprod.107.060293","article-title":"Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice","volume":"77","author":"Hama","year":"2007","journal-title":"Biol Reprod"},{"key":"2025011101232898200_ref48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/ar.1090790205","article-title":"The healing of wounds of the uterus of the mouse","volume":"79","author":"Hooker","year":"1941","journal-title":"Anat Rec"},{"key":"2025011101232898200_ref49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1095\/biolreprod.114.117929","article-title":"Role of uterine contraction in regeneration of the murine postpartum endometrium","volume":"91","author":"Yoshii","year":"2014","journal-title":"Biol Reprod"},{"key":"2025011101232898200_ref50","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nm1197-1209","article-title":"Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels","volume":"3","author":"Ashcroft","year":"1997","journal-title":"Nat Med"},{"key":"2025011101232898200_ref51","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1084\/jem.20100500","article-title":"Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities","volume":"207","author":"Campbell","year":"2010","journal-title":"J Exp Med"},{"key":"2025011101232898200_ref52","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bbi.2008.12.001","article-title":"Sex hormones and mucosal wound healing","volume":"23","author":"Engeland","year":"2009","journal-title":"Brain Behav Immun"},{"key":"2025011101232898200_ref53","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1524-475X.2008.00440.x","article-title":"Effect of estrogen and progesterone on macrophage activation during wound healing","volume":"17","author":"Routley","year":"2009","journal-title":"Wound Repair Regen"},{"key":"2025011101232898200_ref54","article-title":"A direct effect of sex hormones on epithelial barrier function in inflammatory bowel disease models","volume":"8","author":"Giessen","year":"2019","journal-title":"Cells"},{"key":"2025011101232898200_ref55","article-title":"Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer","volume":"7","author":"Horst","year":"2012","journal-title":"PloS One"},{"key":"2025011101232898200_ref56","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/oxfordjournals.aje.a009898","article-title":"Placenta previa: preponderance of male sex at birth","volume":"149","author":"Demissie","year":"1999","journal-title":"Am J Epidemiol"},{"key":"2025011101232898200_ref57","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1210\/endo.139.3.5788","article-title":"Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function","volume":"139","author":"O'Shaughnessy","year":"1998","journal-title":"Endocrinology"},{"key":"2025011101232898200_ref58","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0018-506X(03)00061-8","article-title":"Fetal testosterone surge: specific modulations induced in male rats by maternal stress and\/or alcohol consumption","volume":"43","author":"Ward","year":"2003","journal-title":"Horm Behav"},{"key":"2025011101232898200_ref59","volume-title":"The Physiology of Reproduction","author":"Knobil","year":"1994"},{"key":"2025011101232898200_ref60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol Reprod"},{"key":"2025011101232898200_ref61","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.75351","article-title":"Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model","volume":"1","author":"Sones","year":"2016","journal-title":"JCI Insight"},{"key":"2025011101232898200_ref62","volume":"212","journal-title":"Am J Obstet Gynecol"},{"key":"2025011101232898200_ref63","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fendo.2020.00198","article-title":"Maternal-fetal circadian communication during pregnancy","volume":"11","author":"Bates","year":"2020","journal-title":"Front Endocrinol"},{"key":"2025011101232898200_ref64","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tcm.2017.07.012","article-title":"Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome","volume":"28","author":"Vink","year":"2018","journal-title":"Trends Cardiovasc Med"},{"key":"2025011101232898200_ref65","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioae001\/56741526\/ioae001.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/110\/4\/819\/57214425\/ioae001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/110\/4\/819\/57214425\/ioae001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T01:23:59Z","timestamp":1736558639000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/110\/4\/819\/7516968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,1,11]]},"published-print":{"date-parts":[[2024,4,11]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioae001","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,1,11]]}}}