{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:08:21Z","timestamp":1791612501514,"version":"4.3.4"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD091773"],"award-info":[{"award-number":["R01HD091773"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Disease","doi-asserted-by":"crossref","award":["R01AI154535"],"award-info":[{"award-number":["R01AI154535"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Disease","doi-asserted-by":"crossref","award":["R01AI164504"],"award-info":[{"award-number":["R01AI164504"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["U01EB026421"],"award-info":[{"award-number":["U01EB026421"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"crossref","award":["R01HL167268"],"award-info":[{"award-number":["R01HL167268"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Training Program in Endocrinology, Diabetes, and Metabolism","award":["T32DK007770"],"award-info":[{"award-number":["T32DK007770"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The placenta, composed of chorionic villi, changes dramatically across gestation. Understanding differences in ongoing pregnancies are essential to identify the role of chorionic villi at specific times in gestation and develop biomarkers and prognostic indicators of maternal\u2013fetal health. The normative mRNA profile is established using next-generation sequencing of 124 first trimester and 43 third trimester human placentas from ongoing healthy pregnancies. Stably expressed genes (SEGs) not different between trimesters and with low variability are identified. Differential expression analysis of first versus third trimester adjusted for fetal sex is performed, followed by a subanalysis with 23 matched pregnancies to control for subject variability using the same genetic and environmental background. Placenta expresses 14,979 polyadenylated genes above sequencing noise (transcripts per million\u2009&amp;gt;\u20090.66), with 10.7% SEGs across gestation. Differentially expressed genes (DEGs) account for 86.7% of genes in the full cohort [false discovery rate (FDR)\u2009&amp;lt;\u20090.05]. Fold changes highly correlate between the full cohort and subanalysis (Pearson\u2009=\u20090.98). At stricter thresholds (FDR\u2009&amp;lt;\u20090.001, fold change &amp;gt; 1.5), there remains 50.1% DEGs (3353 upregulated in first and 4155 upregulated in third trimester). This is the largest mRNA atlas of healthy human placenta across gestation, controlling for genetic and environmental factors, demonstrating substantial changes from first to third trimester in chorionic villi. Specific differences and SEGs may be used to understand the specific role of the chorionic villi throughout gestation and develop first trimester biomarkers of placental health that transpire across gestation, which can be used for future development of biomarkers for maternal\u2013fetal health.<\/jats:p>","DOI":"10.1093\/biolre\/ioae007","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T15:18:36Z","timestamp":1706195916000},"page":"936-949","source":"Crossref","is-referenced-by-count":8,"title":["High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester"],"prefix":"10.1093","volume":"110","author":[{"given":"Tania L","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Center for Reproductive Medicine, , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Wertheimer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Center for Reproductive Medicine, , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E","family":"Flowers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Center for Reproductive Medicine, , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Computational Biomedicine, Cedars-Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintda","family":"Santiskulvong","sequence":"additional","affiliation":[{"name":"CS Cancer Applied Genomics Shared Resource, CS Cancer, Cedars-Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina L","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Center for Reproductive Medicine, , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A","family":"Jefferies","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine , Kao Autoimmune Institute, Cedars-Sinai Medical Center, Los Angeles, CA , USA"},{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Lawrenson","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology , Department of Obstetrics and Gynecology, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Department of Obstetrics and Gynecology, , Los Angeles, CA , USA"},{"name":"Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, CA , USA"},{"name":"Women\u2019s Cancer Research Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil V","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Center for Reproductive Medicine, , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA , USA"},{"name":"California NanoSystems Institute , Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, , Los Angeles, CA , USA"},{"name":"University of California, Los Angeles , Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsian-Rong","family":"Tseng","sequence":"additional","affiliation":[{"name":"California NanoSystems Institute , Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, , Los Angeles, CA , USA"},{"name":"University of California, Los Angeles , Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Ananth","family":"Karumanchi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Williams III","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA , USA"},{"name":"Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Division of Maternal-Fetal Medicine, , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta D","family":"Pisarska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"Cedars-Sinai Medical Center , Center for Reproductive Medicine, , Los Angeles, CA , USA"},{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center , Los Angeles, CA , USA"},{"name":"David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"2024051505410802100_ref1","doi-asserted-by":"crossref","DOI":"10.1242\/dev.163428","article-title":"Development of the human placenta","volume":"146","author":"Turco","year":"2019","journal-title":"Development"},{"key":"2024051505410802100_ref2","first-page":"20230191","article-title":"The human placenta: new perspectives on its formation and function during early pregnancy","volume":"290","author":"Burton","year":"2023","journal-title":"Proc Biol Sci"},{"key":"2024051505410802100_ref3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat Rev Genet"},{"key":"2024051505410802100_ref4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/jmg.2003.016881","article-title":"Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling","volume":"41","author":"Tsui","year":"2004","journal-title":"J Med Genet"},{"key":"2024051505410802100_ref5","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1177\/1933719108322425","article-title":"Profiling gene expression in human placentae of different gestational ages: an OPRU network and UW SCOR study","volume":"15","author":"Mikheev","year":"2008","journal-title":"Reprod Sci"},{"key":"2024051505410802100_ref6","doi-asserted-by":"crossref","first-page":"e33294","DOI":"10.1371\/journal.pone.0033294","article-title":"Differences in gene expression between first and third trimester human placenta: a microarray study","volume":"7","author":"Sitras","year":"2012","journal-title":"PloS One"},{"key":"2024051505410802100_ref7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.placenta.2017.08.005","article-title":"Gene markers of normal villous maturation and their expression in placentas with maturational pathology","volume":"58","author":"Leavey","year":"2017","journal-title":"Placenta"},{"key":"2024051505410802100_ref8","doi-asserted-by":"crossref","first-page":"dev156273","DOI":"10.1242\/dev.156273","article-title":"Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development","volume":"145","author":"Soncin","year":"2018","journal-title":"Development"},{"key":"2024051505410802100_ref9","doi-asserted-by":"crossref","first-page":"13336","DOI":"10.1038\/srep13336","article-title":"Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes","volume":"5","author":"S\u00f5ber","year":"2015","journal-title":"Sci Rep"},{"key":"2024051505410802100_ref10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.preghy.2017.04.002","article-title":"Up-regulation of microRNA-202-3p in first trimester placenta of pregnancies destined to develop severe preeclampsia, a pilot study","volume":"10","author":"Singh","year":"2017","journal-title":"Pregn Hypertens"},{"key":"2024051505410802100_ref11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1113\/jphysiol.2006.104968","article-title":"Placental adaptive responses and fetal programming","volume":"572","author":"Myatt","year":"2006","journal-title":"J Physiol"},{"key":"2024051505410802100_ref12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental development in health and disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"2024051505410802100_ref13","doi-asserted-by":"crossref","first-page":"BBI.S28991","DOI":"10.4137\/BBI.S28991","article-title":"Advanced applications of RNA sequencing and challenges","volume":"9s1","author":"Han","year":"2015","journal-title":"Bioinform Biol Insights"},{"key":"2024051505410802100_ref14","doi-asserted-by":"crossref","first-page":"103624","DOI":"10.1016\/j.jri.2022.103624","article-title":"Dynamic genome-wide gene expression and immune cell composition in the developing human placenta","volume":"151","author":"Suryawanshi","year":"2022","journal-title":"J Reprod Immunol"},{"key":"2024051505410802100_ref15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1242\/bio.058222","article-title":"RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition","volume":"10","author":"Prater","year":"2021","journal-title":"Biol Open"},{"key":"2024051505410802100_ref16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13293-018-0165-y","article-title":"Sex differences in the late first trimester human placenta transcriptome","volume":"9","author":"Gonzalez","year":"2018","journal-title":"Biol Sex Differ"},{"key":"2024051505410802100_ref17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/pd.4936","article-title":"Optimization of techniques for multiple platform testing in small, precious samples such as human chorionic villus sampling","volume":"36","author":"Pisarska","year":"2016","journal-title":"Prenat Diagn"},{"key":"2024051505410802100_ref18","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2217\/epi-2021-0055","article-title":"High-throughput miRNA sequencing of the human placenta: expression throughout gestation","volume":"13","author":"Gonzalez","year":"2021","journal-title":"Epigenomics"},{"key":"2024051505410802100_ref19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2024051505410802100_ref20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinform"},{"key":"2024051505410802100_ref21","doi-asserted-by":"crossref","first-page":"e4831","DOI":"10.1210\/clinem\/dgaa503","article-title":"Sexually dimorphic crosstalk at the maternal-Fetal Interface","volume":"105","author":"Sun","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"2024051505410802100_ref22","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"key":"2024051505410802100_ref23","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2024051505410802100_ref24","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1007\/s003350010177","article-title":"Conservation of PCDHX in mammals; expression of human X\/Y genes predominantly in brain","volume":"11","author":"Blanco","year":"2000","journal-title":"Mamm Genome"},{"key":"2024051505410802100_ref25","article-title":"Table S1. Patient demographics and pregnancy outcomes","volume-title":"FigShare","author":"Sun","year":"2020"},{"key":"2024051505410802100_ref26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.molcel.2014.07.012","article-title":"The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites","volume":"55","author":"West","year":"2014","journal-title":"Mol Cell"},{"key":"2024051505410802100_ref27","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature02399","article-title":"The DNA sequence and biology of human chromosome 19","volume":"428","author":"Grimwood","year":"2004","journal-title":"Nature"},{"key":"2024051505410802100_ref28","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.placenta.2015.02.002","article-title":"Review: hCGs: different sources of production, different glycoforms and functions","volume":"36","author":"Fournier","year":"2015","journal-title":"Placenta"},{"key":"2024051505410802100_ref29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/978-0-387-77374-2_12","article-title":"The coupling of alternative splicing and nonsense-mediated mRNA decay","volume":"623","author":"Lareau","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"2024051505410802100_ref30","doi-asserted-by":"crossref","first-page":"7152","DOI":"10.1093\/nar\/gkv655","article-title":"Tight regulation of plant immune responses by combining promoter and suicide exon elements","volume":"43","author":"Gonzalez","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2024051505410802100_ref31","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.977618","article-title":"Three categories of similarities between the placenta and cancer that can aid cancer treatment: cells, the microenvironment, and metabolites","volume":"12","author":"Pang","year":"2022","journal-title":"Front Oncol"},{"key":"2024051505410802100_ref32","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.placenta.2010.03.006","article-title":"Sex differences in the mRNA levels of housekeeping genes in human placenta","volume":"31","author":"Cleal","year":"2010","journal-title":"Placenta"},{"key":"2024051505410802100_ref33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/1440-1681.13172","article-title":"Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy","volume":"47","author":"Fisher","year":"2020","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2024051505410802100_ref34","doi-asserted-by":"crossref","first-page":"18109","DOI":"10.1073\/pnas.1907548116","article-title":"Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia","volume":"116","author":"Yung","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"2024051505410802100_ref35","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.placenta.2017.06.011","article-title":"Changes in mitochondrial respiration in the human placenta over gestation","volume":"57","author":"Holland","year":"2017","journal-title":"Placenta"},{"key":"2024051505410802100_ref36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.placenta.2016.12.012","article-title":"Review: placental mitochondrial function and structure in gestational disorders","volume":"54","author":"Holland","year":"2017","journal-title":"Placenta"},{"key":"2024051505410802100_ref37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.placenta.2016.07.002","article-title":"Mitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy","volume":"45","author":"Mella","year":"2016","journal-title":"Placenta"},{"key":"2024051505410802100_ref38","first-page":"1336","article-title":"Mitochondrial and glycolysis-regulatory gene expression profiles are associated with intrauterine growth restriction","volume":"33","author":"Jones","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2024051505410802100_ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2020.10.002","article-title":"Mitochondrial DNA copy number variation - a potential biomarker for early onset preeclampsia","volume":"23","author":"Pandey","year":"2021","journal-title":"Pregn Hypertens"},{"key":"2024051505410802100_ref40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00418-017-1608-y","article-title":"Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A","volume":"149","author":"Hiden","year":"2018","journal-title":"Histochem Cell Biol"},{"key":"2024051505410802100_ref41","doi-asserted-by":"crossref","first-page":"E7212","DOI":"10.1073\/pnas.1612626113","article-title":"HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia","volume":"113","author":"Chakraborty","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"2024051505410802100_ref42","doi-asserted-by":"crossref","first-page":"7082","DOI":"10.1158\/0008-5472.CAN-07-1872","article-title":"Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor Indoleamine 2,3-dioxygenase inhibitory compound d-1-methyl-tryptophan","volume":"67","author":"Metz","year":"2007","journal-title":"Cancer Res"},{"key":"2024051505410802100_ref43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00726-008-0137-3","article-title":"Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease","volume":"37","author":"Macchiarulo","year":"2009","journal-title":"Amino Acids"},{"key":"2024051505410802100_ref44","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1177\/002215540104900909","article-title":"Placental alkaline phosphatase expression at the apical and basal plasma membrane in term villous trophoblasts","volume":"49","author":"Leitner","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"2024051505410802100_ref45","article-title":"Table S5. Trophoblast subcluster markers in human first trimester","volume-title":"FigShare","author":"Sun","year":"2020"},{"key":"2024051505410802100_ref46","doi-asserted-by":"crossref","first-page":"E2598","DOI":"10.1073\/pnas.1601630113","article-title":"Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas","volume":"113","author":"Yabe","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024051505410802100_ref47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0898-6568(00)00117-0","article-title":"Placental alkaline phosphatase, insulin, and adenine nucleotides or adenosine synergistically promote long-term survival of serum-starved mouse embryo and human fetus fibroblasts","volume":"12","author":"She","year":"2000","journal-title":"Cell Signal"},{"key":"2024051505410802100_ref48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.placenta.2018.02.006","article-title":"Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - liquid biopsies to monitoring fetal growth","volume":"64","author":"Miranda","year":"2018","journal-title":"Placenta"},{"key":"2024051505410802100_ref49","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0143-4004(05)80223-1","article-title":"Expression of human placenta alkaline phosphatase in placenta during pregnancy","volume":"11","author":"Okamoto","year":"1990","journal-title":"Placenta"},{"key":"2024051505410802100_ref50","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/clinchem\/33.10.1801","article-title":"Time-dependent changes in bone, placental, intestinal, and hepatic alkaline phosphatase activities in serum during human pregnancy","volume":"33","author":"Valenzuela","year":"1987","journal-title":"Clin Chem"},{"key":"2024051505410802100_ref51","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1515\/JPEM.2000.13.4.343","article-title":"The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development","volume":"13","author":"Handwerger","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2024051505410802100_ref52","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1210\/jc.2010-0023","article-title":"Differential expression profile of growth hormone\/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns","volume":"95","author":"M\u00e4nnik","year":"2010","journal-title":"J Clin Endocrinol Metabol"},{"key":"2024051505410802100_ref53","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/REP-21-0390","article-title":"Pregnancy-specific glycoproteins: evolution, expression, functions and disease associations","volume":"163","author":"Moore","year":"2022","journal-title":"Reproduction"},{"key":"2024051505410802100_ref54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.8755-8920.2001.450403.x","article-title":"Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes","volume":"45","author":"Snyder","year":"2001","journal-title":"Am J Reprod Immunol"},{"key":"2024051505410802100_ref55","doi-asserted-by":"crossref","DOI":"10.3390\/nu14030628","article-title":"Selenoproteins in the human placenta: how essential is selenium to a healthy start to life?","volume":"14","author":"Hogan","year":"2022","journal-title":"Nutrients"},{"key":"2024051505410802100_ref56","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/aji.12329","article-title":"Interleukin-10: a pleiotropic regulator in pregnancy","volume":"73","author":"Cheng","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"2024051505410802100_ref57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011094","article-title":"Interleukin-15 in outcomes of pregnancy","volume":"22","author":"Gordon","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024051505410802100_ref58","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s10120-021-01259-5","article-title":"Cancer-associated fibroblasts-derived HAPLN1 promotes tumour invasion through extracellular matrix remodeling in gastric cancer","volume":"25","author":"Zhang","year":"2022","journal-title":"Gastric Cancer"},{"key":"2024051505410802100_ref59","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/humrep\/der075","article-title":"Transcriptome analysis reveals dialogues between human trophectoderm and endometrial cells during the implantation period","volume":"26","author":"Haouzi","year":"2011","journal-title":"Hum Reprod"},{"key":"2024051505410802100_ref60","article-title":"Table S2. Placental cell markers from single cell RNA sequencing","volume-title":"FigShare","author":"Sun","year":"2020"},{"key":"2024051505410802100_ref61","doi-asserted-by":"crossref","first-page":"eaau4788","DOI":"10.1126\/sciadv.aau4788","article-title":"A single-cell survey of the human first-trimester placenta and decidua","volume":"4","author":"Suryawanshi","year":"2018","journal-title":"Sci Adv"},{"key":"2024051505410802100_ref62","doi-asserted-by":"crossref","first-page":"1144393","DOI":"10.3389\/fendo.2023.1144393","article-title":"Endometrial proteomic profile of patients with repeated implantation failure","volume":"14","author":"Yang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024051505410802100_ref63","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"2024051505410802100_ref64","doi-asserted-by":"crossref","first-page":"E950","DOI":"10.1152\/ajpendo.00087.2012","article-title":"Comparative expression of hCG \u03b2-genes in human trophoblast from early and late first-trimester placentas","volume":"303","author":"Cocquebert","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioae007\/56612564\/ioae007.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/110\/5\/936\/57468395\/ioae007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/110\/5\/936\/57468395\/ioae007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T03:30:50Z","timestamp":1715743850000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/110\/5\/936\/7589762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":64,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,1,25]]},"published-print":{"date-parts":[[2024,5,9]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioae007","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.06.06.543972","asserted-by":"object"}]},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,1,25]]}}}