{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:14:49Z","timestamp":1787008489169,"version":"build-2736575974"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072706"],"award-info":[{"award-number":["32072706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1901206"],"award-info":[{"award-number":["U1901206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>FOXP2 was initially characterized as a transcription factor linked to speech and language disorders. Single-cell RNA sequencing reveals that Foxp2 is enriched in the gonadotrope cluster of the pituitary gland and colocalized with the hormones LHB and FSHB in chickens and mice, implying that FOXP2 might be associated with reproduction in vertebrates. Herein, we investigated the roles of foxp2 in reproduction in a Foxp2-deficient zebrafish model. The results indicated that the loss of Foxp2 inhibits courtship behavior in adult male zebrafish. Notably, Foxp2 deficiency disrupts gonad development, leading to retardation of follicle development and a decrease in oocytes in females at the full-growth stage, among other phenotypes. The transcriptome analysis (RNA-seq) also revealed that differentially expressed genes clustered into the estrogen signaling and ovarian steroidogenesis-related signaling pathways. In addition, we found that Foxp2 deficiency could modulate the hypothalamic\u2013pituitary\u2013gonadal axis, especially the regulation of lhb and fshb expression, in zebrafish. In contrast, the injection of human chorionic gonadotropin, a specific LH agonist, partially rescues Foxp2-impaired reproduction in zebrafish, suggesting that Foxp2 plays an important role in the regulation of reproduction via the hypothalamic\u2013pituitary\u2013gonadal axis in zebrafish. Thus, our findings reveal a new role for Foxp2 in the regulation of reproduction in vertebrates.<\/jats:p>","DOI":"10.1093\/biolre\/ioae019","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T15:45:19Z","timestamp":1706370319000},"page":"908-923","source":"Crossref","is-referenced-by-count":5,"title":["Foxp2 deficiency impairs reproduction by modulating the hypothalamic\u2013pituitary\u2013gonadal axis in zebrafish"],"prefix":"10.1093","volume":"110","author":[{"given":"Maya","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioresources and Eco-environment of Ministry of Education , College of Life Science, , Chengdu , China"},{"name":"Sichuan University , College of Life Science, , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioresources and Eco-environment of Ministry of Education , College of Life Science, , Chengdu , China"},{"name":"Sichuan University , College of Life Science, , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioresources and Eco-environment of Ministry of Education , College of Life Science, , Chengdu , China"},{"name":"Sichuan University , College of Life Science, , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilan","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioresources and Eco-environment of Ministry of Education , College of Life Science, , Chengdu , China"},{"name":"Sichuan University , College of Life Science, , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioresources and Eco-environment of Ministry of Education , College of Life Science, , Chengdu , China"},{"name":"Sichuan University , College of Life Science, , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioresources and Eco-environment of Ministry of Education , College of Life Science, , Chengdu , China"},{"name":"Sichuan University , College of Life Science, , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioresources and Eco-environment of Ministry of Education , College of Life Science, , Chengdu , China"},{"name":"Sichuan University , College of Life Science, , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[{"name":"Shantou University Medical College , Shantou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioresources and Eco-environment of Ministry of Education , College of Life Science, , Chengdu , China"},{"name":"Sichuan University , College of Life Science, , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"2024051505465957300_ref1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/nm.f.1895","article-title":"The biology of infertility: research advances and clinical challenges","volume":"14","author":"Matzuk","year":"2008","journal-title":"Nat Med"},{"key":"2024051505465957300_ref2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: definition and epidemiology","volume":"62","author":"Vander 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