{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:33:13Z","timestamp":1790202793151,"version":"4.1.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R00HD090229"],"award-info":[{"award-number":["R00HD090229"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51OD011092"],"award-info":[{"award-number":["P51OD011092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008143","name":"Oregon National Primate Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intrauterine infection is a significant cause of neonatal morbidity and mortality. Ureaplasma parvum is a microorganism commonly isolated from cases of preterm birth and preterm premature rupture of membranes (pPROM). However, the mechanisms of early stage ascending reproductive tract infection remain poorly understood. To examine inflammation in fetal (chorioamnionic) membranes we utilized a non-human primate (NHP) model of choriodecidual U. parvum infection. Eight chronically catheterized pregnant rhesus macaques underwent maternal\u2013fetal catheterization surgery at ~105\u2013112 days gestation and choriodecidual inoculation with U. parvum (105 CFU\/mL, n\u2009=4) or sterile media (controls; n\u2009=\u20094) starting at 115\u2013119 days, repeated at 5-day intervals until C-section at 136\u2013140 days (term=167 days). The average inoculation to delivery interval was 21 days, and Ureaplasma infection of the amniotic fluid (AF) was undetectable in all animals. Choriodecidual Ureaplasma infection resulted in increased fetal membrane expression of MMP-9 and PTGS2, but did not result in preterm labor or increased concentrations of AF pro-inflammatory cytokines. However, membrane expression of inflammasome sensors, NLRP3, NLRC4, AIM2, and NOD2, and adaptor ASC (PYCARD) gene expression were significantly increased. Gene expression of IL-1\u03b2, IL-18, IL-18R1 \u00a0, CASPASE-1, and pro-CASPASE-1 protein increased with Ureaplasma infection. Downstream inflammatory genes MYD88 and NF\u03baB (Nuclear factor kappa-light-chain-enhancer of activated B cells) were also significantly upregulated. These results demonstrate that choriodecidual\u00a0Ureaplasma infection, can cause activation of inflammasome complexes and pathways associated with pPROM and preterm labor prior to microbes being detectable in the AF.<\/jats:p>","DOI":"10.1093\/biolre\/ioae027","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T21:53:08Z","timestamp":1707429188000},"page":"971-984","source":"Crossref","is-referenced-by-count":11,"title":["Membrane inflammasome activation by choriodecidual <i>Ureaplasma parvum<\/i> infection without intra-amniotic infection in a Non-Human Primate model"],"prefix":"10.1093","volume":"110","author":[{"given":"Sudeshna","family":"Tripathy","sequence":"first","affiliation":[{"name":"Division of Reproductive and Developmental Sciences , Oregon National Primate Research Center, , Beaverton, OR , USA"},{"name":"Oregon Health and Science University , Oregon National Primate Research Center, , Beaverton, OR , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Burd","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Gynecology and Reproductive Sciences, , Baltimore, MD , USA"},{"name":"University of Maryland School of Medicine , Gynecology and Reproductive Sciences, , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith A","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences , Oregon National Primate Research Center, , Beaverton, OR , USA"},{"name":"Oregon Health and Science University , Oregon National Primate Research Center, , Beaverton, OR , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"2024051505470018200_ref1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology 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