{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:09:58Z","timestamp":1790179798835,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1DA056493"],"award-info":[{"award-number":["DP1DA056493"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RDSP K12 HD000849"],"award-info":[{"award-number":["RDSP K12 HD000849"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 HD097116"],"award-info":[{"award-number":["R03 HD097116"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD108833"],"award-info":[{"award-number":["R01 HD108833"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD086331"],"award-info":[{"award-number":["R01 HD086331"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51-OD-011092"],"award-info":[{"award-number":["P51-OD-011092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although the central role of adequate blood flow and oxygen delivery is known, the lack of optimized imaging modalities to study placental structure has impeded our understanding of its vascular function. Magnetic resonance imaging is increasingly being applied in this field, but gaps in knowledge remain, and further methodological developments are needed. In particular, the ability to distinguish maternal from fetal placental perfusion and the understanding of how individual placental lobules are functioning are lacking. The potential clinical benefits of developing noninvasive tools for the in vivo assessment of blood flow and oxygenation, two key determinants of placental function, are tremendous. Here, we summarize a number of structural and functional magnetic resonance imaging techniques that have been developed and applied in animal models and studies of human pregnancy over the past decade. We discuss the potential applications and limitations of these approaches. Their combination provides a novel source of contrast to allow analysis of placental structure and function at the level of the lobule. We outline the physiological mechanisms of placental T2 and T2* decay and devise a model of how tissue composition affects the observed relaxation properties. We apply this modeling to longitudinal magnetic resonance imaging data obtained from a preclinical pregnant nonhuman primate model to provide initial proof-of-concept data for this methodology, which quantifies oxygen transfer and placental structure across and between lobules. This method has the potential to improve our understanding and clinical management of placental insufficiency once validation in a larger nonhuman primate cohort is complete.<\/jats:p>","DOI":"10.1093\/biolre\/ioae035","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T18:34:00Z","timestamp":1709663640000},"page":"1065-1076","source":"Crossref","is-referenced-by-count":7,"title":["Magnetic resonance imaging of placental intralobule structure and function in a preclinical nonhuman primate model"],"prefix":"10.1093","volume":"110","author":[{"given":"Andrew","family":"Melbourne","sequence":"first","affiliation":[{"name":"King\u2019s College London School of Biomedical Engineering and Imaging Sciences, , London, UK"},{"name":"Elizabeth Garrett Anderson Institute for Women\u2019s Health, University College London Department of Obstetrics and Maternal Fetal Medicine, , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias C","family":"Schabel","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University Advanced Imaging Research Center, , Portland, OR, USA"},{"name":"University of Utah Utah Center for Advanced Imaging Research, , Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L","family":"David","sequence":"additional","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women\u2019s Health, University College London Department of Obstetrics and Maternal Fetal Medicine, , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria H J","family":"Roberts","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center, Oregon Health and Science University Division of Reproductive and Developmental Sciences, , Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2024061704422954300_ref1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.placenta.2014.02.012","article-title":"The human placenta project: placental structure, development, and function in real time","volume":"35","author":"Guttmacher","year":"2014","journal-title":"Placenta"},{"key":"2024061704422954300_ref2","doi-asserted-by":"crossref","first-page":"20140066","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2024061704422954300_ref3","doi-asserted-by":"crossref","DOI":"10.1159\/000410663","article-title":"Basic morphology of the fetal and maternal circuits in the human 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