{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:32:11Z","timestamp":1787639531210,"version":"build-2736575974"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705900"],"award-info":[{"award-number":["2023YFC2705900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171664"],"award-info":[{"award-number":["82171664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101762"],"award-info":[{"award-number":["82101762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301909"],"award-info":[{"award-number":["82301909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Chongqing Municipality of China","award":["CSTB2022NS\u00b7CQ-LZX0062"],"award-info":[{"award-number":["CSTB2022NS\u00b7CQ-LZX0062"]}]},{"name":"Natural Science Foundation of Chongqing Municipality of China","award":["cstc2021jcyj-msxmX0236"],"award-info":[{"award-number":["cstc2021jcyj-msxmX0236"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The purpose of this study is to investigate the role of high mobility group protein B1 (HMGB1) in placental development and fetal growth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We employed the Cre-loxP recombination system to establish a placenta-specific HMGB1 knockout mouse model. Breeding HMGB1flox\/flox mice with Elf5-Cre mice facilitated the knockout, leveraging Elf5 expression in extra-embryonic ectoderm, ectoplacental cone, and trophoblast giant cells at 12.5\u00a0days of embryonic development. The primary goal of this model was to elucidate the molecular mechanism of HMGB1 in placental development, assessing parameters such as placental weight, fetal weight, and bone development. Additionally, we utilized lentiviral interference and overexpression of HMGB1 in human trophoblast cells to further investigate HMGB1\u2019s functional role.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our findings indicate that the HMGB1flox\/floxElf5cre\/+ mouse displays fetal growth restriction, characterized by decreased placental and fetal weight and impaired bone development. The absence of HMGB1 inhibits autophagosome formation, impairs lysosomal degradation, and disrupts autophagic flux. Depletion of HMGB1 in human trophoblast cells also suppresses cell viability, proliferation, migration, and invasion by inhibiting the ERK signaling pathway. Overexpression of HMGB1 observed the opposite phenotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>HMGB1 participates in the regulation of autophagy through the ERK signaling pathway and affects placental development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/biolre\/ioae064","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T15:03:02Z","timestamp":1713798182000},"page":"414-426","source":"Crossref","is-referenced-by-count":17,"title":["HMGB1 regulates autophagy of placental trophoblast through ERK signaling pathway"],"prefix":"10.1093","volume":"111","author":[{"given":"Ming-Rui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Women and Children\u2019s Hospital of Chongqing Medical University , Chongqing , China"},{"name":"Department of Toxicology , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"},{"name":"Chongqing Medical University , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics , School of Basic Medical Sciences, , Chongqing , China"},{"name":"Chongqing Medical University , School of Basic Medical Sciences, , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Hang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Toxicology , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"},{"name":"Chongqing Medical University , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Lan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Women and Children\u2019s Hospital of Chongqing Medical University , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Toxicology , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"},{"name":"Chongqing Medical University , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Toxicology , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"},{"name":"Chongqing Medical University , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Long","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Toxicology , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"},{"name":"Chongqing Medical University , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics , School of Basic Medical Sciences, , Chongqing , China"},{"name":"Chongqing Medical University , School of Basic Medical Sciences, , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Bin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Women and Children\u2019s Hospital of Chongqing Medical University , Chongqing , China"},{"name":"Department of Toxicology , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , Chongqing , China"},{"name":"Chongqing Medical University , Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, , 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