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Autophagy is a paramount intracellular degradation system that facilitates the transportation of proteins, cytoplasmic components, and organelles to lysosomes for degradation and recycling. Preeclampsia and intrauterine growth retardation are two common complications of pregnancy associated with abnormal trophoblast differentiation and placental dysfunctions and have a major impact on fetal development and maternal health. The intricate interplay between endoplasmic reticulum stress, and autophagy and their impact on pregnancy outcomes, through mediating trophoblast differentiation and placental development, has been highlighted in various reports. Autophagy controls trophoblast regulation through a variety of gene expressions and signaling pathways while excessive endoplasmic reticulum stress triggers downstream apoptotic signaling, culminating in trophoblast apoptosis. This comprehensive review delves into the intricacies of placental development and explores the underlying mechanisms of preeclampsia and intrauterine growth retardation. In addition, this review will elucidate the molecular mechanisms of endoplasmic reticulum stress and autophagy, both individually and in their interplay, in mediating placental development and trophoblast differentiation, particularly highlighting their roles in preeclampsia and intrauterine growth retardation development. This research seeks to the interplay between endoplasmic reticulum stress and impaired autophagy in the placental trophoderm, offering novel insights into their contribution to pregnancy complications.<\/jats:p>","DOI":"10.1093\/biolre\/ioae066","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T14:53:31Z","timestamp":1714316011000},"page":"292-311","source":"Crossref","is-referenced-by-count":16,"title":["The interaction of ER stress and autophagy in trophoblasts: navigating pregnancy outcome"],"prefix":"10.1093","volume":"111","author":[{"given":"Yi","family":"Zheng","sequence":"first","affiliation":[{"name":"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Yangzhou University , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"},{"name":"Yangzhou University , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zha","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Yangzhou University , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"},{"name":"Yangzhou University , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Yangzhou University , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"},{"name":"Yangzhou University , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabrouk","family":"Elsabagh","sequence":"additional","affiliation":[{"name":"Department of Animal Production and Technology, Faculty of Agricultural Sciences and Technologies, Ni\u011fde \u00d6mer Halisdemir University , Nigde , Turkey"},{"name":"Department of Nutrition and Clinical Nutrition , Faculty of Veterinary Medicine, , KafrelSheikh , Egypt"},{"name":"Kafrelsheikh University , Faculty of Veterinary Medicine, , KafrelSheikh , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Yangzhou University , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"},{"name":"Yangzhou University , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Yangzhou University , College of Animal Science and Technology, , Yangzhou , People\u2019s Repubic of China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"},{"name":"Yangzhou University , the Ministry of Education of China, , Yangzhou , People\u2019s Republic of China"},{"name":"State Key Laboratory of Sheep Genetic Improvement and Healthy Production , Xinjiang Academy of Agricultural Reclamation Science, Shihezi, P. 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