{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:31:18Z","timestamp":1785238278141,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003406","name":"TEKES","doi-asserted-by":"crossref","award":["589\/31\/2015"],"award-info":[{"award-number":["589\/31\/2015"]}],"id":[{"id":"10.13039\/501100003406","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Forendo Pharma"},{"name":"Vetcare Oy"},{"name":"Oy Medix Biochemica Ab"},{"DOI":"10.13039\/501100005609","name":"University of Turku","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EVO"},{"name":"Academy of Finland, Signe and Ane Gyllenberg Foundation"},{"name":"Sigrid Juselius Foundation"},{"name":"University of Helsinki Research Funds"},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004037","name":"Juho Vainio Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation for Pediatric Research and P\u00e4ivikki"},{"name":"Sakari Sohlberg Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is a steroid synthetic enzyme expressed in ovarian granulosa cells and placental syncytiotrophoblasts. Here, HSD17B1 serum concentration was measured with a validated immunoassay during pregnancy at three time points (12\u201314, 18\u201320 and 26\u201328\u00a0weeks of gestation). The concentration increased 2.5-fold (P\u2009&amp;lt;\u20090.0001) and 1.7-fold (P\u2009=\u20090.0019) during the follow-up period for control women and women who later developed preeclampsia (PE), respectively, and a significant difference was observed at weeks 26\u201328 (P\u2009=\u20090.0266). HSD17B1 concentration at all the three time points positively correlated with serum PAPPA measured at the first time point (first time point r\u2009=\u20090.38, P\u2009=\u20091.1\u2009\u00d7\u200910\u221210; second time point r\u2009=\u20090.27, P\u2009=\u20095.9\u2009\u00d7\u200910\u22126 and third timepoint r\u2009=\u20090.26, P\u2009=\u20092.3\u2009\u00d7\u200910\u22125). No correlation was observed between HSD17B1 and placental growth factor (PLGF). Serum HSD17B1 negatively correlated with the mother\u2019s weight and body mass index (BMI), mirroring the pattern observed for PAPPA. The univariable logistic regression identified a weak association between HSD17B1 at 26\u201328\u00a0weeks and later development of PE (P\u2009=\u20090.04). The best multivariable model obtained using penalized logistic regression with stable iterative variable selection at 26\u201328\u00a0weeks included HSD17B1, together with PLGF, PAPPA and mother\u2019s BMI. While the area under the receiver operating characteristic curve of the model was higher than that of the adjusted PLGF, the difference was not statistically significant. In summary, the serum concentration of HSD17B1 correlated with PAPPA, another protein expressed in syncytiotrophoblasts, and with mother\u2019s weight and BMI but could not be considered as an independent marker for PE.<\/jats:p>","DOI":"10.1093\/biolre\/ioae078","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T21:02:54Z","timestamp":1716411774000},"page":"436-447","source":"Crossref","is-referenced-by-count":1,"title":["Serum hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein A but does not serve as an independent marker for preeclampsia"],"prefix":"10.1093","volume":"111","author":[{"given":"Taija","family":"Heinosalo","sequence":"first","affiliation":[{"name":"Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niina","family":"Saarinen","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku , Turku , Finland"},{"name":"Forendo Pharma , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Biehl","sequence":"additional","affiliation":[{"name":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle T","family":"Rytk\u00f6nen","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku , Turku , Finland"},{"name":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia M","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juuso","family":"Juhila","sequence":"additional","affiliation":[{"name":"Actim , Espoo , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi","family":"Koskimies","sequence":"additional","affiliation":[{"name":"Forendo Pharma , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asta","family":"Laiho","sequence":"additional","affiliation":[{"name":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry , Institute of Clinical Medicine, , Kuopio , Finland"},{"name":"University of Eastern Finland , Institute of Clinical Medicine, , Kuopio , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Kajantie","sequence":"additional","affiliation":[{"name":"Population Health Unit, Finnish Institute for Health and Welfare , Helsinki and Oulu , Finland"},{"name":"Clinical Medicine Research Unit , MRC Oulu, , Oulu , Finland"},{"name":"Oulu University Hospital and University of Oulu , MRC Oulu, , Oulu , Finland"},{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katri","family":"R\u00e4ikk\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki , Helsinki , Finland"},{"name":"Department of Psychology and Logopedics, University of Helsinki , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L","family":"Elo","sequence":"additional","affiliation":[{"name":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University , Turku , Finland"},{"name":"Institute of Biomedicine, University of Turku , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannele","family":"Laivuori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa , Tampere , Finland"},{"name":"Center for Child, Adolescence and Maternal Health, Faculty of Medicine and Health Technology, Tampere University , Tampere , Finland"},{"name":"Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital , Helsinki , Finland"},{"name":"Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Poutanen","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"2024081605154292900_ref1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1210\/er.2016-1065","article-title":"From pregnancy to preeclampsia: a key role for Estrogens","volume":"38","author":"Berkane","year":"2017","journal-title":"Endocr 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