{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:22:32Z","timestamp":1781090552212,"version":"3.54.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21 HD110610"],"award-info":[{"award-number":["R21 HD110610"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD037831"],"award-info":[{"award-number":["R01 HD037831"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Genome Technology Access Center at the McDonnell Genome Institute at Washington University School of Medicine"},{"name":"NCI Cancer Center","award":["P30 CA91842"],"award-info":[{"award-number":["P30 CA91842"]}]},{"DOI":"10.13039\/100014571","name":"Siteman Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014571","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ICTS\/CTSA","award":["UL1TR002345"],"award-info":[{"award-number":["UL1TR002345"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Over 35% of reproductive-age women in the USA have obesity, putting them at increased risk for numerous obstetric complications due to abnormal labor. While the association between maternal obesity and abnormal labor has been well documented, the mechanisms responsible for this remain understudied. The uterine smooth muscle, myometrium, has high energy needs in order to fuel regular uterine contractions during parturition. However, the precise mechanisms by which the myometrium meets its energy demands has not been defined. Here, our objective was to define the effects of obesity on energy utilization in the myometrium during labor. We generated a mouse model of maternal diet-induced obesity and found that these mice had a higher rate of dystocia than control chow-fed mice. Moreover, compared to control chow-fed mice, DIO mice at term, both before and during labor had lower in vivo spontaneous uterine contractility. Untargeted transcriptomic and metabolomic analyses suggest that diet-induced obesity is associated with elevated long-chain fatty acid uptake and utilization in the uterus, but also an accumulation of medium-chain fatty acids. Diet-induced obesity uteri also had an increase in the abundance of long chain-specific beta-oxidation enzymes, which may be responsible for the observed increase in long-chain fatty acid utilization. This altered energy substrate utilization may be a contributor to the observed contractile dysfunction.<\/jats:p>","DOI":"10.1093\/biolre\/ioae086","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T18:45:07Z","timestamp":1718045107000},"page":"678-693","source":"Crossref","is-referenced-by-count":10,"title":["Obese mice have decreased uterine contractility and altered energy metabolism in the uterus at term gestation"],"prefix":"10.1093","volume":"111","author":[{"given":"Kevin K","family":"Prifti","sequence":"first","affiliation":[{"name":"Center for Reproductive Health Sciences , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"},{"name":"Washington University in St. Louis , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Center for Reproductive Health Sciences , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"},{"name":"Washington University in St. Louis , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Reproductive Health Sciences , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"},{"name":"Washington University in St. Louis , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian N","family":"Finck","sequence":"additional","affiliation":[{"name":"Department of Medicine , Center for Human Nutrition, , St. Louis, MO , USA"},{"name":"Washington University in St. Louis , Center for Human Nutrition, , St. Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K","family":"England","sequence":"additional","affiliation":[{"name":"Center for Reproductive Health Sciences , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"},{"name":"Washington University in St. Louis , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6491-6910","authenticated-orcid":false,"given":"Antonina I","family":"Frolova","sequence":"additional","affiliation":[{"name":"Center for Reproductive Health Sciences , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"},{"name":"Washington University in St. Louis , Department of Obstetrics and Gynecology, , St. Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"2024091602161724500_ref1","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1001\/jama.2016.6458","article-title":"Trends in obesity among adults in the United States, 2005 to 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