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The effects of increased age on the testis and the general mechanisms involved in testicular pathology leading to infertility are still only poorly understood. However, there is growing evidence that link testicular aging and idiopathic male infertility to local inflammatory and oxidative stress events. Because literature data strongly indicate that melatonin exhibits anti-inflammatory and anti-oxidant properties, this review focuses on the potential benefits exerted by this indoleamine at testicular level in male reproductive fertility and aging. Taking into account that the effects of melatonin supplementation on testicular function are currently being investigated, the overview covers not only promising prospects but also many questions concerning the future therapeutic value of this indoleamine as an anti-aging drug as well as in the management of cases of male infertility for which there are no medical treatments currently available.<\/jats:p>","DOI":"10.1093\/biolre\/ioae087","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:41:58Z","timestamp":1718347318000},"page":"543-556","source":"Crossref","is-referenced-by-count":20,"title":["Melatonin as a natural anti-inflammatory and anti-oxidant therapy in the testis: a focus on infertility and aging"],"prefix":"10.1093","volume":"111","author":[{"given":"M\u00f3nica Beatriz","family":"Frungieri","sequence":"first","affiliation":[{"name":"Laboratorio de Neuro-Inmuno-Endocrinolog\u00eda Testicular, Instituto de Biolog\u00eda y Medicina Experimental, Fundaci\u00f3n Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas , Ciudad de Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Sa\u00fal","family":"Calandra","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuro-Inmuno-Endocrinolog\u00eda Testicular, Instituto de Biolog\u00eda y Medicina Experimental, Fundaci\u00f3n Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas , Ciudad de Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Matzkin","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuro-Inmuno-Endocrinolog\u00eda Testicular, Instituto de Biolog\u00eda y Medicina Experimental, Fundaci\u00f3n Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas , Ciudad de Buenos Aires , Argentina"},{"name":"C\u00e1tedra 1 , Bioqu\u00edmica Humana, Facultad de Medicina, , Ciudad de Buenos Aires , Argentina"},{"name":"Universidad de Buenos Aires , Bioqu\u00edmica Humana, Facultad de Medicina, , Ciudad de Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad Paola","family":"Rossi","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuro-Inmuno-Endocrinolog\u00eda Testicular, Instituto de Biolog\u00eda y Medicina Experimental, Fundaci\u00f3n Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas , Ciudad de Buenos Aires , Argentina"},{"name":"C\u00e1tedra 1 , Bioqu\u00edmica Humana, Facultad de Medicina, , Ciudad de Buenos Aires , Argentina"},{"name":"Universidad de Buenos Aires , Bioqu\u00edmica Humana, Facultad de Medicina, , Ciudad de Buenos Aires , 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