{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:11:53Z","timestamp":1758125513540,"version":"3.37.3"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"crossref","award":["2017\/25\/B\/NZ9\/00040"],"award-info":[{"award-number":["2017\/25\/B\/NZ9\/00040"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Interactions between female metabolic status, immune response, and reproductive system functioning are complex and not fully understood. We hypothesized that chemerin, considered a hormonal link between the above-mentioned processes, influences endometrial functions, particularly cytokine secretion and signaling. Using porcine endometrial explants collected during early pregnancy and the estrous cycle, we investigated chemerin effects on the secretion of interleukins (IL-1\u03b2, IL-6, and IL-8), leukemia inhibitory factor, tumor necrosis factor \u03b1, transforming growth factor \u03b1, and protein abundances of their respective receptors. Our results demonstrate chemerin modulation of cytokine secretion and receptor expression, with effects dependent on the stage of pregnancy and dose of chemerin. Furthermore, chemerin influences the phosphorylation of stress-activated protein kinase\/Jun-amino-terminal kinase and nuclear factor kappa-light-chain-enhancer of activated B cells in the endometrium. Chemerin multifaceted actions, such as involvement in immune response, cell proliferation, and tissue remodeling, seem to be mediated by cytokines, at least in the endometrium. These findings underscore the potential crosstalk between chemerin and hormonal signaling pathways, providing insights into the complex mechanisms underlying early pregnancy establishment and maintenance.<\/jats:p>","DOI":"10.1093\/biolre\/ioae117","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:57:14Z","timestamp":1722934634000},"page":"1030-1044","source":"Crossref","is-referenced-by-count":1,"title":["Chemerin affects the cytokine production and the expression of their receptors in the porcine endometrium during early pregnancy and the estrous cycle: an in vitro study"],"prefix":"10.1093","volume":"111","author":[{"given":"Marta","family":"Kiezun","sequence":"first","affiliation":[{"name":"Department of Animal Anatomy and Physiology , Faculty of Biology and Biotechnology, , Olsztyn ,","place":["Poland"]},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Dobrzyn","sequence":"additional","affiliation":[{"name":"Department of Zoology , Faculty of Biology and Biotechnology, , Olsztyn ,","place":["Poland"]},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology , Faculty of Biology and Biotechnology, , Olsztyn ,","place":["Poland"]},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Smolinska","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology , Faculty of Biology and Biotechnology, , Olsztyn ,","place":["Poland"]},{"name":"University of Warmia and Mazury in Olsztyn , Faculty of Biology and Biotechnology, , Olsztyn ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"2024111511471760600_ref1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0014-5793(03)01312-7","article-title":"Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23","volume":"555","author":"Meder","year":"2003","journal-title":"FEBS Lett"},{"key":"2024111511471760600_ref2","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1084\/jem.20080300","article-title":"Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis","volume":"205","author":"Zabel","year":"2008","journal-title":"J Exp Med"},{"key":"2024111511471760600_ref3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/iub.1242","article-title":"Processing, signaling, and physiological function of chemerin","volume":"66","author":"Mattern","year":"2014","journal-title":"IUBMB Life"},{"key":"2024111511471760600_ref4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cca.2020.02.008","article-title":"Chemerin in immune response and gastrointestinal pathophysiology","volume":"504","author":"Jacenik","year":"2020","journal-title":"Clin Chim Acta"},{"key":"2024111511471760600_ref5","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1084\/jem.20071601","article-title":"Synthetic chemerin-derived peptides suppress inflammation through ChemR23","volume":"205","author":"Cash","year":"2008","journal-title":"J Exp Med"},{"key":"2024111511471760600_ref6","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3390\/ijms23020945","article-title":"Chemerin affects P4 and E2 synthesis in the porcine endometrium during early pregnancy","volume":"23","author":"Gudelska","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2024111511471760600_ref7","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1017\/S175173112000097X","article-title":"The expression of chemerin and its receptors (CMKLR1, GPR1, CCRL2) in the porcine uterus during the oestrous cycle and early pregnancy and in trophoblasts and conceptuses","volume":"14","author":"Gudelska","year":"2020","journal-title":"Animal"},{"key":"2024111511471760600_ref8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1074\/jbc.M805000200","article-title":"Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets","volume":"284","author":"Du","year":"2009","journal-title":"J Biol Chem"},{"key":"2024111511471760600_ref9","first-page":"115","article-title":"Role of uterine immune cells in early pregnancy in pigs","volume":"52","author":"Engelhardt","year":"1997","journal-title":"J Reprod Fertil Suppl"},{"key":"2024111511471760600_ref10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0378-4320(00)00211-6","article-title":"The sow endometrium at different stages of the oestrous cycle: studies on morphological changes and infiltration by cells of the immune system","volume":"65","author":"Kaeoket","year":"2001","journal-title":"Anim Reprod Sci"},{"key":"2024111511471760600_ref11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-4320(02)00222-1","article-title":"Cytokines during early pregnancy of mammals: a review","volume":"75","author":"Sch\u00e4fer-Somi","year":"2003","journal-title":"Anim Reprod Sci"},{"key":"2024111511471760600_ref12","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1095\/biolreprod.103.015842","article-title":"Characterization of the interleukin-1\u03b2 system during porcine trophoblastic elongation and early placental attachment","volume":"69","author":"Ross","year":"2003","journal-title":"Biol Reprod"},{"key":"2024111511471760600_ref13","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1439-0531.2006.00716.x","article-title":"Role of tumour necrosis factor \u03b1 in stimulation of prostaglandins F2\u03b1 and E2 release by cultured porcine endometrial cells","volume":"41","author":"Blitek","year":"2006","journal-title":"Reprod Domest Anim"},{"key":"2024111511471760600_ref14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1189\/jlb.0708395","article-title":"Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment","volume":"85","author":"Mourik","year":"2008","journal-title":"J Leukoc Biol"},{"key":"2024111511471760600_ref15","first-page":"733","article-title":"Interleukin 1\u03b2-induced synthesis and secretion of prostaglandin E2 in the porcine uterus during various periods of pregnancy and the estrous cycle","volume":"61","author":"Franczak","year":"2010","journal-title":"J Physiol Pharmacol"},{"key":"2024111511471760600_ref16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/cells9112466","article-title":"Activation of c-Jun N-terminal kinase, a potential therapeutic target in autoimmune arthritis","volume":"9","author":"Lai","year":"2020","journal-title":"Cells"},{"key":"2024111511471760600_ref17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2024111511471760600_ref18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020945","article-title":"Chemerin affects P4 and E2 synthesis in the porcine endometrium during early pregnancy","volume":"23","author":"Gudelska","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2024111511471760600_ref19","first-page":"90","article-title":"NF-kB transcription factor: a key player in the generation of immune response","author":"Tripathi","year":"2006","journal-title":"Curr Sci"},{"key":"2024111511471760600_ref20","first-page":"40","article-title":"The uterine secretory activity and its physiological changes in the pig","volume":"55","author":"Stanis\u0142aw","year":"2014","journal-title":"Acta Biol Cracov Ser Zool"},{"key":"2024111511471760600_ref21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1439-0531.2011.01843.x","article-title":"Mechanisms for the establishment of pregnancy in the pig","volume":"46","author":"Ziecik","year":"2011","journal-title":"Reprod Domest Anim"},{"key":"2024111511471760600_ref22","first-page":"1953","article-title":"Gross ovarian changes during estrous cycle of swine","volume":"29","author":"Akins","year":"1968","journal-title":"Am J Vet Res"},{"key":"2024111511471760600_ref23","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1093\/biolre\/ioab126","article-title":"Chemerin as a modulator of angiogenesis and apoptosis processes in the corpus luteum of pigs: an in vitro study","volume":"105","author":"Rytelewska","year":"2021","journal-title":"Biol Reprod"},{"key":"2024111511471760600_ref24","first-page":"338","article-title":"Effect of progesterone on adiponectin system in the porcine uterus during early pregnancy","volume":"95","author":"Dobrzyn","year":"2017","journal-title":"J Anim Sci"},{"key":"2024111511471760600_ref25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/ar.1091900112","article-title":"Growth, protein content and distribution of early pig embryos","volume":"190","author":"Anderson","year":"1978","journal-title":"Anat Rec"},{"key":"2024111511471760600_ref26","first-page":"443","article-title":"Effect of adiponectin on the steroidogenic acute regulatory protein, p450 side chain cleavage enzyme and 3\u0392-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione production by the porcine uterus during early pregnancy","volume":"67","author":"Smolinska","year":"2016","journal-title":"J Physiol Pharmacol"},{"key":"2024111511471760600_ref27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.theriogenology.2020.10.040","article-title":"Chemerin as a modulator of ovarian steroidogenesis in pigs: an in vitro study","volume":"160","author":"Rytelewska","year":"2021","journal-title":"Theriogenology"},{"key":"2024111511471760600_ref28","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.3390\/ijms20163887","article-title":"Expression of chemerin and its receptors in the porcine hypothalamus and plasma chemerin levels during the oestrous cycle and early pregnancy","volume":"20","author":"Smolinska","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024111511471760600_ref29","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1071\/RD23148","article-title":"Chemerin affects the expression of angiogenesis-related factors in the porcine endometrium during early pregnancy and the oestrous cycle: an in vitro study","volume":"35","author":"Kiezun","year":"2023","journal-title":"Reprod Fertil Dev"},{"key":"2024111511471760600_ref30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/cells11071161","article-title":"Chemerin effect on the endometrial proteome of the domestic pig during implantation obtained by LC-MS\/MS analysis","volume":"11","author":"Orzechowska","year":"2022","journal-title":"Cells"},{"key":"2024111511471760600_ref31","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/biolre\/ioac063","article-title":"Chemerin effect on transcriptome of the porcine endometrium during implantation determined by RNA-sequencing","volume":"107","author":"Orzechowska","year":"2022","journal-title":"Biol Reprod"},{"key":"2024111511471760600_ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15761\/JPR.1000124","article-title":"Defining pregnancy phases with cytokine shift","volume":"1","author":"Dutta","year":"2017","journal-title":"J Pregnancy Reprod"},{"key":"2024111511471760600_ref33","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1439-0531.2008.01082.x","article-title":"Uterine expression of epidermal growth factor family during the course of pregnancy in pigs","volume":"44","author":"Kim","year":"2009","journal-title":"Reprod Domest Anim"},{"key":"2024111511471760600_ref34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.12749\/RDB.2014.38.1.9","article-title":"Maternal-conceptus interactions: mediators regulating the implantation process in pigs","volume":"38","author":"Choi","year":"2014","journal-title":"Reprod Develop Biol"},{"key":"2024111511471760600_ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.112.099051","article-title":"Regulatory mechanism for expression of IL1B receptors in the uterine endometrium and effects of IL1B on prostaglandin synthetic enzymes during the implantation period in pigs","volume":"87","author":"Seo","year":"2012","journal-title":"Biol Reprod"},{"key":"2024111511471760600_ref36","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1530\/REP-16-0047","article-title":"Interleukins, interferons, and establishment of pregnancy in pigs","volume":"151","author":"Mathew","year":"2016","journal-title":"Reproduction"},{"key":"2024111511471760600_ref37","doi-asserted-by":"crossref","first-page":"208103","DOI":"10.1155\/2014\/208103","article-title":"Interleukins affect equine endometrial cell function: modulatory action of ovarian steroids","volume":"2014","author":"Sz\u00f3stek","year":"2014","journal-title":"Mediators Inflamm"},{"key":"2024111511471760600_ref38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.theriogenology.2013.03.020","article-title":"The effect of interleukin 1\u03b2 and interleukin 6 on estradiol-17\u03b2 secretion in the endometrium of pig during early pregnancy and the estrous cycle","volume":"80","author":"Franczak","year":"2013","journal-title":"Theriogenology"},{"key":"2024111511471760600_ref39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.mce.2015.10.022","article-title":"Stimulatory effects of interleukin-1 beta on development of porcine uterine epithelial cell are mediated by activation of the ERK1\/2 MAPK cell signaling cascade","volume":"419","author":"Jeong","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"2024111511471760600_ref40","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/mrd.22835","article-title":"Embryo-maternal dialogue during pregnancy establishment and implantation in the pig","volume":"84","author":"Waclawik","year":"2017","journal-title":"Mol Reprod Dev"},{"key":"2024111511471760600_ref41","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.theriogenology.2012.05.016","article-title":"Regulation of expression and role of leukemia inhibitory factor and interleukin-6 in the uterus of early pregnant pigs","volume":"78","author":"Blitek","year":"2012","journal-title":"Theriogenology"},{"key":"2024111511471760600_ref42","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5713\/ajas.18.0429","article-title":"Leukemia inhibitory factor and its receptor: expression and regulation in the porcine endometrium throughout the estrous cycle and pregnancy","volume":"32","author":"Yoo","year":"2019","journal-title":"Asian Australas J Anim Sci"},{"key":"2024111511471760600_ref43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.theriogenology.2017.04.007","article-title":"Expression and regulation of interleukin 6 and its receptor at the maternal-conceptus interface during pregnancy in pigs","volume":"96","author":"Yoo","year":"2017","journal-title":"Theriogenology"},{"key":"2024111511471760600_ref44","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1053\/plac.1999.0493","article-title":"Pregnancy-dependent expression of leukaemia inhibitory factor (LIF). LIF receptor-\u03b2 and interleukin-6 (IL-6) messenger ribonucleic acids in the porcine female reproductive tract","volume":"21","author":"Modri\u0107","year":"2000","journal-title":"Placenta"},{"key":"2024111511471760600_ref45","doi-asserted-by":"crossref","first-page":"062","DOI":"10.1055\/s-0028-1108011","article-title":"The role of growth factors and cytokines during implantation: endocrine and paracrine interactions","volume":"27","author":"Guzeloglu-Kayisli","year":"2009","journal-title":"Semin Reprod Med"},{"key":"2024111511471760600_ref46","first-page":"2014:201514","article-title":"Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception","author":"Salleh","year":"2014","journal-title":"Sci World J"},{"key":"2024111511471760600_ref47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/rda.14142","article-title":"Immunological uterine response to pig embryos before and during implantation","volume":"57","author":"Parrilla","year":"2022","journal-title":"Reprod Domest Anim"},{"key":"2024111511471760600_ref48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/molehr\/8.4.375","article-title":"Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation","volume":"8","author":"Caballero-Campo","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"2024111511471760600_ref49","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/humrep\/des132","article-title":"CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN\/AKT signal pathway","volume":"27","author":"Li","year":"2012","journal-title":"Hum Reprod"},{"key":"2024111511471760600_ref50","first-page":"9","article-title":"Chemokines as the modulators of endometrial epithelial cells remodelling","volume":"9","author":"Z\u0142otkowska","year":"2019","journal-title":"Sci Rep"},{"key":"2024111511471760600_ref51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1290\/0404033.1","article-title":"Interleukin-8 can stimulate progesterone secretion from a human trophoblast cell line, BeWo","volume":"40","author":"Tsui","year":"2004","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"2024111511471760600_ref52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11010-012-1515-4","article-title":"Interleukin-8 stimulates progesterone production via the MEK pathway in ovarian theca cells","volume":"374","author":"Shimizu","year":"2013","journal-title":"Mol Cell Biochem"},{"key":"2024111511471760600_ref53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cyto.2011.11.007","article-title":"Effects of interleukin-8 on estradiol and progesterone production by bovine granulosa cells from large follicles and progesterone production by luteinizing granulosa cells in culture","volume":"57","author":"Shimizu","year":"2012","journal-title":"Cytokine"},{"key":"2024111511471760600_ref54","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1016\/j.fertnstert.2021.07.554","article-title":"The role of CXCR2 and its ligands in attachment, migration, and invasion of mouse endometriosis cells","volume":"116","author":"Peterson","year":"2021","journal-title":"Fertil Steril"},{"key":"2024111511471760600_ref55","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1530\/REP-09-0341","article-title":"Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9 and integrins \u03b15 and \u03b21","volume":"139","author":"Jovanovi\u0107","year":"2010","journal-title":"Reproduction"},{"key":"2024111511471760600_ref56","first-page":"21:e12447","article-title":"Embryos, cancers, and parasites: potential applications to the study of reproductive biology in view of their similarity as biological phenomena","author":"Araki","year":"2022","journal-title":"Reprod Med Biol"},{"key":"2024111511471760600_ref57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-4320(97)00081-X","article-title":"Elevation in tumour necrosis factor-alpha (TNF-\u03b1) messenger RNA levels in the uterus of pregnant gilts after oestrogen treatment","volume":"50","author":"Yu","year":"1998","journal-title":"Anim Reprod Sci"},{"key":"2024111511471760600_ref58","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.theriogenology.2013.09.024","article-title":"The effect of interleukin-1\u03b2, interleukin-6, and tumor necrosis factor-\u03b1 on estradiol-17\u03b2 release in the myometrium: the invitro study on the pig model","volume":"81","author":"Franczak","year":"2014","journal-title":"Theriogenology"},{"key":"2024111511471760600_ref59","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/biom10040554","article-title":"Pig pregnancies after transfer of allogeneic embryos show a dysregulated endometrial\/placental cytokine balance: a novel clue for embryo death?","volume":"10","author":"Martinez","year":"2020","journal-title":"Biomolecules"},{"key":"2024111511471760600_ref60","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1530\/REP-10-0092","article-title":"Oxytocin and tumor necrosis factor \u03b1 stimulate expression of prostaglandin E2 synthase and secretion of prostaglandin E2 by luminal epithelial cells of the porcine endometrium during early pregnancy","volume":"140","author":"Waclawik","year":"2010","journal-title":"Reproduction"},{"key":"2024111511471760600_ref61","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.placenta.2008.10.012","article-title":"Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium","volume":"30","author":"Haider","year":"2009","journal-title":"Placenta"},{"key":"2024111511471760600_ref62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004451","article-title":"The epidermal growth factor receptor critically regulates endometrial function during early pregnancy","volume":"10","author":"Large","year":"2014","journal-title":"PLoS Genet"},{"key":"2024111511471760600_ref63","first-page":"936","article-title":"Growth factors in the human endometrium","volume-title":"Human Reproduction Update","author":"Smith","year":"1994"},{"key":"2024111511471760600_ref64","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1242\/dev.116.3.663","article-title":"Expression of the genes for TGF\u03b1, EGF and the EGF receptor during early pig development","volume":"116","author":"Vaughan","year":"1992","journal-title":"Development"},{"key":"2024111511471760600_ref65","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2108\/zsj.29.377","article-title":"Transforming growth factor-\u03b1 mRNA expression and its possible roles in mouse endometrial stromal cells","volume":"29","author":"Maekawa","year":"2012","journal-title":"Zoolog Sci"},{"key":"2024111511471760600_ref66","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00418-008-0421-z","article-title":"Expression and regulation of c-Jun N-terminal kinase (JNK) in endometrial cells in vivo and in vitro","volume":"130","author":"Kizilay","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"2024111511471760600_ref67","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-8-39","article-title":"Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig","volume":"8","author":"Ross","year":"2010","journal-title":"Reprod Biol Endocrinol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioae117\/58742496\/ioae117.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/111\/5\/1030\/60603550\/ioae117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/111\/5\/1030\/60603550\/ioae117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T11:47:44Z","timestamp":1731671264000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/111\/5\/1030\/7727864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":67,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,8,6]]},"published-print":{"date-parts":[[2024,11,11]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioae117","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"type":"print","value":"0006-3363"},{"type":"electronic","value":"1529-7268"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,8,6]]}}}