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The reproductive system, responsible for transmitting genetic material in animals, is one of the most sensitive systems to environmental toxins. Research reveals that Sertoli cells are the primary target cells for the action of environmental toxins. Different environmental toxins mostly affect the blood\u2013testis barrier and lead to male reproductive disorders by disrupting Sertoli cells. Therefore, this article provides an in-depth exploration of the toxic mechanisms of various types of environmental toxins on the male testes. It reveals the dynamic processes of tight junctions in the blood\u2013testis barrier affected by environmental toxins and their specific roles in the reconstruction process.<\/jats:p>","DOI":"10.1093\/biolre\/ioae126","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T13:40:28Z","timestamp":1724506828000},"page":"977-986","source":"Crossref","is-referenced-by-count":23,"title":["Environmental toxins and reproductive health: unraveling the effects on Sertoli cells and the blood\u2013testis barrier in animals"],"prefix":"10.1093","volume":"111","author":[{"given":"Biao","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University , Haikou, Hainan 570228,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diqi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University , Haikou, Hainan 570228,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University , Haikou, Hainan 570228,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"key":"2024111511472496500_ref1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/humupd\/dmac035","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries","volume":"29","author":"Levine","year":"2023","journal-title":"Hum Reprod Update"},{"key":"2024111511472496500_ref2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3945\/ajcn.112.042432","article-title":"High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population","volume":"97","author":"Jensen","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"2024111511472496500_ref3","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.fertnstert.2008.12.018","article-title":"Semen quality 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