{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:38:57Z","timestamp":1792597137980,"version":"4.5.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306349\/2017-5"],"award-info":[{"award-number":["306349\/2017-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["420152\/2018-0"],"award-info":[{"award-number":["420152\/2018-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sao Paulo Research Foundation","award":["2023\/04558-8"],"award-info":[{"award-number":["2023\/04558-8"]}]},{"name":"Sao Paulo Research Foundation","award":["2022\/01505-8"],"award-info":[{"award-number":["2022\/01505-8"]}]},{"name":"Sao Paulo Research Foundation","award":["2021\/09886-8"],"award-info":[{"award-number":["2021\/09886-8"]}]},{"name":"Sao Paulo Research Foundation","award":["2021\/06645-0"],"award-info":[{"award-number":["2021\/06645-0"]}]},{"name":"Sao Paulo Research Foundation","award":["2017\/19681-9"],"award-info":[{"award-number":["2017\/19681-9"]}]},{"name":"Sao Paulo Research Foundation","award":["2015\/21829-9"],"award-info":[{"award-number":["2015\/21829-9"]}]},{"name":"Sao Paulo Research Foundation","award":["2014\/22887-0"],"award-info":[{"award-number":["2014\/22887-0"]}]},{"name":"Sao Paulo Research Foundation","award":["2013\/08135-2"],"award-info":[{"award-number":["2013\/08135-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The first interactions among the embryo, endometrium, and corpus luteum are essential for pregnancy success. Small extracellular vesicles (sEVs) are part of these interactions. We previously demonstrated that small extracellular vesicles from in vivo- or in vitro-produced bovine embryos contain different miRNA cargos. Herein we show: (1) the presence and origin (in vivo or in vitro) of the blastocyst differentially reprograms endometrial transcriptional profiles; (2) the endometrial explant (EE) cultured with in vivo or in vitro embryos release small extracellular vesicles with different miRNA contents, and (3) the luteal explant (CLE) exposed to these small extracellular vesicles have distinct mRNA and miRNA profiles. To elucidate this, the endometrial explant were cultured in the presence or absence of a single Day-7 in vivo (EE\u2013artificial insemination; EE-AI) or in vitro (EE\u2013in vitro fertilization; EE-IVF) embryo. After of culture we found, in the endometrial explant, 45 and 211 differentially expressed genes associated with embryo presence and origin, respectively. Small extracellular vesicles were recovered from the conditioned media (CM) in which endometrial explant and embryos were co-cultured. Four miRNAs were differentially expressed between small extracellular vesicles from CC-EE-AI and CC-EE-IVF. Luteal explants exposed in culture to these small extracellular vesicles showed 1360 transcripts and 15 miRNAs differentially expressed. The differentially expressed genes associated with embryo presence and origin, modulating cells\u2019 proliferation, and survival. These results demonstrate that in vivo- or in vitro-produced bovine embryos induce molecular alterations in the endometrium; and that the embryo and endometrium release small extracellular vesicles capable of modifying the messenger RNA (mRNA) and miRNA\u00a0profile in the corpus luteum. Therefore, the small extracellular vesicles-mediated embryo\u2013endometrium\u2013corpus luteum interactions possibly regulate the corpus luteum viability to ensure pregnancy success.<\/jats:p>","DOI":"10.1093\/biolre\/ioae143","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:42:26Z","timestamp":1728574946000},"page":"54-69","source":"Crossref","is-referenced-by-count":13,"title":["Small extracellular vesicles derived from the crosstalk between early embryos and the endometrium potentially mediate corpus luteum function"],"prefix":"10.1093","volume":"112","author":[{"given":"Alessandra","family":"Bridi","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano Rodrigues","family":"Sangalli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Perecin","family":"Nociti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica Camargo","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Genetics and Evolution, Federal University of S\u00e3o Carlos , Rodovia Washington Lu\u00eds, km 235, 13565-905, S\u00e3o Carlos ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Marins","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana de \u00c1vila","family":"Ferronato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Maria da Silva","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariani Farias","family":"Fiorenza","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Pugliesi","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction , Faculty of Veterinary Medicine and Animal Science, , Av. Prof. Dr. Orlando Marques de Paiva, 87, 05508-270, S\u00e3o Paulo ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Veterinary Medicine and Animal Science, , Av. Prof. Dr. Orlando Marques de Paiva, 87, 05508-270, S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Vieira","family":"Meirelles","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Roberto","family":"Chiaratti","sequence":"additional","affiliation":[{"name":"Department of Genetics and Evolution, Federal University of S\u00e3o Carlos , Rodovia Washington Lu\u00eds, km 235, 13565-905, S\u00e3o Carlos ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano Coelho","family":"da Silveira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine , Faculty of Animal Science and Food Engineering, , Av. Duque de Caxias Norte, 225, 13635-900, Pirassununga ,","place":["Brazil"]},{"name":"University of S\u00e3o Paulo , Faculty of Animal Science and Food Engineering, , Av. 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