{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:55:39Z","timestamp":1768773339260,"version":"3.49.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2019YFA0802600"],"award-info":[{"award-number":["2019YFA0802600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170863"],"award-info":[{"award-number":["32170863"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871512"],"award-info":[{"award-number":["31871512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Commission of Science and Technology","award":["20DZ2270900"],"award-info":[{"award-number":["20DZ2270900"]}]},{"name":"Jinan Municipal Health Commission Science and Technology Plan Project","award":["2023-1-43"],"award-info":[{"award-number":["2023-1-43"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Preeclampsia (PE) is a condition of pregnancy in which symptoms of hypertension develop after 20\u00a0weeks of gestation. it can lead to placental dysfunction, maternal and perinatal mortality and morbidity. The incidence of PE is increasing, posing a serious threat to the lives of pregnant women and their unborn children. Currently, most of the research on the pathogenesis of PE has focused on placenta, However, maternal decidualization is the basis for placental formation and growth. Chondroitin sulfate proteoglycan 4 (CSPG4) is a transmembrane protein that plays a role in cell proliferation, invasion, and migration. However, its function during decidualization is not yet understood. In this study, we investigated the role of CSPG4 and found that its expression was significantly down-regulated in the decidual tissue of patients with severe PE compared to normal pregnant women. During artificially induced decidualization, CSPG4 expression was significantly increased. Knockdown of CSPG4 by small interfering RNA inhibited decidualization, which, in turn, inhibited the invasion of trophoblast cells. In both pseudopregnant and pregnant mice, endometrial stromal cells proliferated rapidly and Cspg4 expression increased during decidualization. Therefore, we believe that CSPG4 plays a crucial role in the process of decidualization. The defect in decidualization caused by abnormal CSPG4 expression could lead to insufficient trophoblast invasion, ultimately contributing to the occurrence of PE.<\/jats:p>","DOI":"10.1093\/biolre\/ioae167","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:43:29Z","timestamp":1732092209000},"page":"361-374","source":"Crossref","is-referenced-by-count":2,"title":["CSPG4 involvement in endometrial decidualization contributes to the pathogenesis of preeclampsia"],"prefix":"10.1093","volume":"112","author":[{"given":"Tianying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai ,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai ,","place":["China"]},{"name":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University , Jinan, Shandong ,","place":["China"]},{"name":"Taishan Polytechnic , Taian, Shandong 271000 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ji\u2019nan Maternity and Child Care Hospital , Jinan, Shandong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enhui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University , Jinan, Shandong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Translational Medicine, Jinan Central Hospital Affiliated to Shandong First Medical University , Jinan, Shandong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences , Jinan, Shandong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai ,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai ,","place":["China"]},{"name":"Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University , Jinan, Shandong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"2025021811332818100_ref1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/2096-2924.320886","article-title":"Insights into the pathogenesis of preeclampsia based on the features of placentation and tumorigenesis","volume":"5","author":"Zhu","year":"2021","journal-title":"Reproductive and Developmental Medicine"},{"key":"2025021811332818100_ref2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia","volume":"5","author":"Young","year":"2010","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"2025021811332818100_ref3","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.3390\/ijms20174246","article-title":"Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental 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