{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:44:37Z","timestamp":1785789877919,"version":"3.56.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministry of Science and Higher Education","doi-asserted-by":"publisher","award":["DI2019 0110 49"],"award-info":[{"award-number":["DI2019 0110 49"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Visfatin regulates energy homeostasis, metabolism, inflammation, and reproduction via the hypothalamus-pituitary-ovary axis. Our previous study showed the visfatin gene and protein expression in the human placenta. This study aimed to investigate the in vitro effect of visfatin on the proliferation and apoptosis of placental JEG-3 and BeWo cells but also in villous explants collected from normal pregnancies and complicated by intrauterine growth restriction (IUGR), preeclampsia (PE), and gestational diabetes mellitus (GDM). We studied placenta cells viability, proliferation, cell cycle, proliferation\/apoptotic factors and insulin receptor (INSR) expression, DNA fragmentation, CASP3\/7 activity, and phosphorylation of ERK1\/2, AKT, AMPK\u03b1, STAT3 with their involvement after pharmacological inhibition in visfatin action on proliferation and apoptosis. Visfatin (1, 10, 100\u00a0ng\/mL) decreased the viability and proliferation of JEG-3 after 48\u00a0h, and a similar effect was observed via co-administration of visfatin (10\u00a0ng\/mL) and insulin (10\u00a0ng\/mL) in JEG-3 and BeWo after 48\u00a0h and 72\u00a0h, respectively. Visfatin reduced the transition from the G2\/M phase, and expression of PCNA or cyclins D, E, A, and B in JEG-3 and PCNA in normal, IUGR, PE, and GDM placentas. It increased DNA fragmentation, CASP3\/7 activity, P53, BAX\/BCL2, CASP9, CASP 8, CASP3 levels in BeWo, and CASP3 expression in tested placentas. Furthermore, visfatin modulated INSR, ERK1\/2, AKT, AMPK\u03b1, and STAT3 expression in JEG-3 and BeWo, and its anti-proliferative and pro-apoptotic effects occurred via mentioned factors. In conclusion, visfatin, by affecting the proliferation and apoptosis of human placenta cells, may be an important factor in the development and function of the organ.<\/jats:p>","DOI":"10.1093\/biolre\/ioae168","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T18:13:49Z","timestamp":1732040029000},"page":"375-391","source":"Crossref","is-referenced-by-count":5,"title":["Visfatin exerts an anti-proliferative and pro-apoptotic effect in the human placenta cells"],"prefix":"10.1093","volume":"112","author":[{"given":"Monika","family":"Dawid","sequence":"first","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Doctoral School of Exact and Natural Sciences , ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Pich","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Doctoral School of Exact and Natural Sciences , ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Respekta-D\u0142ugosz","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Doctoral School of Exact and Natural Sciences , ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktoria","family":"Gieras","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Opydo","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Hematology , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Milewicz","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology , Faculty of Medicine, ,","place":["Poland"]},{"name":"Jagiellonian University Medical College , Faculty of Medicine, ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Froment","sequence":"additional","affiliation":[{"name":"INRAE, Unit\u00e9 Physiologie de la Reproduction et des Comportements ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Dupont","sequence":"additional","affiliation":[{"name":"INRAE, Unit\u00e9 Physiologie de la Reproduction et des Comportements ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Rak","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Toxicology of Reproduction , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]},{"name":"Jagiellonian University in Krakow , Institute of Zoology and Biomedical Research, Faculty of Biology, ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"2025021811355387000_ref1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.2174\/092986708785133004","article-title":"Visfatin: structure, function and relation to diabetes mellitus and other dysfunctions","volume":"15","author":"Adeghate","year":"2008","journal-title":"Curr Med Chem"},{"key":"2025021811355387000_ref2","first-page":"9","article-title":"Visfatin\u2014a 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