{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T02:20:37Z","timestamp":1781490037729,"version":"3.54.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Plan Project"},{"name":"Journal of Jinan University High-Level Science and Technology Journal Construction Project","award":["2021B121020012"],"award-info":[{"award-number":["2021B121020012"]}]},{"name":"Guangdong Provincial Administration of Traditional Chinese Medicine, Traditional Chinese Medicine Research Project","award":["20213005"],"award-info":[{"award-number":["20213005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer known for its toxic effects on the male reproductive system. Green tea polyphenols (GTPs), recognized for their antioxidant and anti-inflammatory properties, have demonstrated protective effects on various organs, but the mechanisms by which GTPs mitigate DEHP-induced testicular damage remain unclear. Healthy male C57BL\/6J mice were divided into five groups: control, DEHP, DEHP + GTP treatment, GTP, and oil groups. Testicular histopathological changes were assessed using hematoxylin\u2013eosin (H&amp;E), periodic acid-Schiff (PAS), and Masson staining. Ultrastructural alterations were examined through transmission electron microscopy. High-throughput sequencing was performed to analyze the expression of mRNA, miRNA, and lncRNA and construct an lncRNA\u2013miRNA\u2013mRNA regulatory network for identifying key regulatory axes. Mice in the DEHP group exhibited significant testicular damage, including reduced sperm count, mitochondrial deformation, and endoplasmic reticulum dilation. GTP treatment notably improved testicular structural integrity, restored sperm count, and alleviated mitochondrial and endoplasmic reticulum damage. Additionally, DEHP significantly increased activated CD8+ T cells, which were reduced with GTP treatment. High-throughput sequencing revealed that GTP treatment exerted protective effects through the regulation of six key lncRNA\u2013miRNA\u2013mRNA axes. GTPs significantly protect against DEHP-induced testicular damage, and the lncRNA\u2013miRNA\u2013mRNA regulatory axes play a potential role in this process.<\/jats:p>","DOI":"10.1093\/biolre\/ioae179","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T03:11:33Z","timestamp":1733886693000},"page":"485-500","source":"Crossref","is-referenced-by-count":5,"title":["Green tea polyphenols alleviate di (2-ethylhexyl) phthalate-induced testicular injury in mice via lncRNA\u2013miRNA\u2013mRNA axis"],"prefix":"10.1093","volume":"112","author":[{"given":"Heng","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine , The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Ave, Guangzhou 510630,","place":["China"]},{"name":"Department of Gastroenterology , The Central Hospital of Shaoyang, No. 360, Baoqing Middle Road, Hongqi Street, Daxiang District, Shaoyang 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510630,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Si","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology , The Central Hospital of Shaoyang, No. 360, Baoqing Middle Road, Hongqi Street, Daxiang District, Shaoyang 42200,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Chuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine , The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Ave, Guangzhou 510630,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Yu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gynecologic , Jiangmen Hospital Affiliated to Jinan University, No. 30, Huayuan East Road, Jiangmen 529000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine , The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Ave, Guangzhou 510630,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine , The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Ave, Guangzhou 510630,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"2025031708035510200_ref1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ecoenv.2018.07.066","article-title":"Di (2-ethylhexyl) phthalate-induced reproductive toxicity involved in DNA damage-dependent oocyte apoptosis and 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