{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:35:03Z","timestamp":1772138103853,"version":"3.50.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009633","name":"NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD102533"],"award-info":[{"award-number":["R01HD102533"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In vitro fertilization is a widely used assisted reproductive technology to achieve a successful pregnancy. However, the acquisition of oxidative stress in embryo in vitro culture impairs its competence. Here, we demonstrated that a nuclear coding gene, methyltransferase-like protein 7A, improves the developmental potential of bovine embryos. We found that exogenous methyltransferase-like protein 7A modulates expression of genes involved in embryonic cell mitochondrial pathways and promotes trophectoderm development. Surprisingly, we discovered that methyltransferase-like protein 7A alleviates mitochondrial stress and DNA damage and promotes cell cycle progression during embryo cleavage. In summary, we have identified a novel mitochondria stress eliminating mechanism regulated by methyltransferase-like protein 7A that occurs during the acquisition of oxidative stress in embryo in vitro culture. This discovery lays the groundwork for the development of methyltransferase-like protein 7A as a promising therapeutic target for in vitro fertilization embryo competence.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf018","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T15:24:52Z","timestamp":1738077892000},"page":"628-639","source":"Crossref","is-referenced-by-count":4,"title":["METTL7A improves bovine IVF embryo competence by attenuating oxidative stress"],"prefix":"10.1093","volume":"112","author":[{"given":"Linkai","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, Genetics Institute, University of Florida , Gainesville, FL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Genetics Institute, University of Florida , Gainesville, FL 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