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Loss of SUMOylation in nongrowing oocytes by conditional deletion of the E2 SUMO conjugating enzyme, Ube2i, at the primordial follicle stage leads to female sterility due to complex changes in oocyte development, including altered folliculogenesis, defective meiotic progression, and premature loss of the ovarian reserve. In this study, proteomics was used to compare control and Ube2i conditional knockout ovaries during the first wave of folliculogenesis to identify key differences that may drive the premature follicle loss phenotype. Label-free mass spectrometry results showed that 238 proteins were significantly altered more than 2-fold (p\u2009&amp;lt;\u20090.05). Proteins upregulated in the Ube2i conditional knockout ovaries included those involved in mRNA splicing and WNT signaling, while those downregulated were related to metabolism, mitochondria, and the maternal effect proteins NLRP2 and NLRP9B. The majority of differentially expressed proteins showed no change by transcriptome analysis, indicating protein level regulation and revealing potential SUMOylation targets with necessary roles in oocyte and follicle development.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf035","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T23:20:56Z","timestamp":1740093656000},"page":"932-941","source":"Crossref","is-referenced-by-count":4,"title":["Disruption of oocyte SUMOylation impacts critical regulatory processes during folliculogenesis in mice"],"prefix":"10.1093","volume":"112","author":[{"given":"Zian","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX ,","place":["United States"]},{"name":"Graduate School of Biomedical Sciences , , Houston, TX ,","place":["United States"]},{"name":"Genetics & Genomics Graduate Program, Baylor College of Medicine , , Houston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa E","family":"Steenwinkel","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX ,","place":["United States"]},{"name":"Graduate School of Biomedical Sciences , , Houston, TX ,","place":["United States"]},{"name":"Development, Disease Models, and Therapeutics Graduate Program, Baylor College of Medicine , , Houston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Moscoso","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Salas","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany K","family":"Patton","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX ,","place":["United States"]},{"name":"Graduate School of Biomedical Sciences , , Houston, TX ,","place":["United States"]},{"name":"Molecular & Cellular Biology Graduate Program, Baylor College of Medicine , , Houston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX ,","place":["United States"]},{"name":"Graduate School of Biomedical Sciences , , Houston, TX ,","place":["United States"]},{"name":"Molecular & Cellular Biology Graduate Program, Baylor College of Medicine , , Houston, TX ,","place":["United 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