{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:40:45Z","timestamp":1785451245682,"version":"3.56.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The etiology of polycystic ovary syndrome (PCOS) remains unknown. However, emerging evidence is increasingly suggesting that ovarian inflammation and fibrosis are among the primary causes of pathological changes. Sorafenib is a multiple kinases inhibitor that targets receptor tyrosine kinases including vascular endothelial growth factor receptor and platelet-derived growth factor receptor. Sorafenib was found to inhibit the activation of nuclear factor kappa B (NF-\u03baB). However, the effects of sorafenib on PCOS ovarian inflammation and fibrosis remained unknown. Our findings demonstrated that sorafenib effectively inhibited the platelet-derived growth factor subunit A (PDGFA)\/platelet-derived growth factor receptor \u03b1 axis, which subsequently led to the suppression of NF-\u03baB activation. This inhibition further resulted in a decrease in chemokine expression, thereby impeding the recruitment and polarization of macrophages. Consequently, this process resulted in the downregulation of collagen deposition. These results provide a new perspective and direction for the clinical treatment of PCOS.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf082","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T06:33:10Z","timestamp":1746167590000},"page":"423-435","source":"Crossref","is-referenced-by-count":5,"title":["Sorafenib inhibits ovarian inflammation and fibrosis in polycystic ovary syndrome by targeting the PDGFA\/PDGFR\u03b1\/NF-\u03baB pathway in granulosa cells"],"prefix":"10.1093","volume":"113","author":[{"given":"Xitong","family":"Liu","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University , Shanghai 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